Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs

Abstract

Declaration of transparency and scientific rigour: This Declaration acknowledges that this paper adheres to the principles for transparent reporting and scientific rigour of preclinical research as stated in the BJP guidelines for Design and Analysis, and Animal Experimentation, and as recommended by funding agencies, publishers and other organisations engaged with supporting research. Short title: Hemodynamic side effects of torsadogenic hERG blocking drugs Author contribution: Data analysis was performed by P.C. Manuscript was written by P.C., J.T. and J.Y.L. and critically evaluated by R.F. and S.R. Principal components analysis and hierarchical clustering analysis were performed by T.B.