Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

Avecilla, Andrea; Doke, Mayur; Jovellanos, Jeremy; Avecilla, Vincent

doi:10.3390/medsci6030061

Cited by 6 publications

(8 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the diverse genetic pattern obtained from whole-genome methylation sequencing between WT and dnmt3aa KO fish, neurod6b, ptfa1, mafba, isl2a, uncx4.1, dmbx1b, and mab21l2 were associated with neural development, which indicated that dnmt3aa KO affects neurons through these genes. Neurod6, an abbreviation of neurogenetic differentiation 6, was reported to associate with the neurodevelopmental disease, long-term potentiation, as well as synaptic transmission defects [105,106]. In addition, ptfa1 was also considered as one of the regulators of transcriptional homeodomain during neuronal specification [107].…”

Section: The Differences In Neurotransmitters and Methylation Level Of Dnmt3a Gene-deficient Zebrafishmentioning

confidence: 99%

Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

Lai

Audira

Liang

et al. 2020

Genes

View full text Add to dashboard Cite

DNA methylation plays several roles in regulating neuronal proliferation, differentiation, and physiological functions. The major de novo methyltransferase, DNMT3, controls the DNA methylation pattern in neurons according to environmental stimulations and behavioral regulations. Previous studies demonstrated that knockout of Dnmt3 induced mouse anxiety; however, controversial results showed that activation of Dnmt3 causes anxiolytic behavior. Thus, an alternative animal model to clarify Dnmt3 on modulating behavior is crucial. Therefore, we aimed to establish a zebrafish (Danio rerio) model to clarify the function of dnmt3 on fish behavior by behavioral endpoint analyses. We evaluated the behaviors of the wild type, dnmt3aa, and dnmt3ab knockout (KO) fish by the novel tank, mirror biting, predator avoidance, social interaction, shoaling, circadian rhythm locomotor activity, color preference, and short-term memory tests. The results indicated that the dnmt3aa KO fish possessed abnormal exploratory behaviors and less fear response to the predator. On the other hand, dnmt3ab KO fish displayed less aggression, fear response to the predator, and interests to interact with their conspecifics, loosen shoaling formation, and dysregulated color preference index ranking. Furthermore, both knockout fishes showed higher locomotion activity during the night cycle, which is a sign of anxiety. However, changes in some neurotransmitter levels were observed in the mutant fishes. Lastly, whole-genome DNA methylation sequencing demonstrates a potential network of Dnmt3a proteins that is responsive to behavioral alterations. To sum up, the results suggested that the dnmt3aa KO or dnmt3ab KO fish display anxiety symptoms, which supported the idea that Dnmt3 modulates the function involved in emotional control, social interaction, and cognition.

show abstract

Section: The Differences In Neurotransmitters and Methylation Level Of Dnmt3a Gene-deficient Zebrafishmentioning

confidence: 99%

Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

Lai

Audira

Liang

et al. 2020

Genes

View full text Add to dashboard Cite

show abstract

“…Animal studies investigated the effect of known or potential EDCs on neural development via direct or indirect effect on aromatase, estrogen receptors and androgen receptors [17,[46][47][48][49]. Population studies concluded that similar effects exist in human, specifically linking thyroid disruptors during fetal development with cognitive and behavioral impairment [22,[50][51][52][53][54][55] even at low doses.…”

Section: Endocrine Disruptors and Human Healthmentioning

confidence: 99%

“…Nonetheless, while animal studies showed a clear activity of bisphenol A and its correlation with adverse effects on female fertility and pregnancy outcomes [22,48], human study results are still conflicting. Some studies seem to exclude adverse effects of BPA [32], while others report adverse effects on child development and behavior [50][51][52].…”

Section: Bisphenol Amentioning

confidence: 99%

Endocrine Disruption by Mixtures in Topical Consumer Products

Ripamonti¹,

Allifranchini²,

Todeschi³

et al. 2018

Cosmetics

View full text Add to dashboard Cite

Endocrine disruption has been gathering increasing attention in the past 25 years as a possible new threat for health and safety. Exposure to endocrine disruptor has been progressively linked with a growing number of increasing disease in the human population. The mechanics through which endocrine disruptors act are not yet completely clear, however a number of pathways have been identified. A key concern is the cumulative and synergic effects that endocrine disruptors could have when mixed in consumer products. We reviewed the available literature to identify known or potential endocrine disruptors, as well as endocrine active substances that could contribute to cumulative effects, in topical consumer products. The number of endocrine actives used daily in consumer products is staggering and even though most if not all are used in concentrations that are considered to be safe, we believe that the possibility of combined effects in mixtures and non-monotonic dose/response is enough to require further precautions. A combined in vitro approach based on existing, validated OECD test methods is suggested to screen consumer products and mixtures for potential interaction with estrogen and androgen hormone receptors, in order to identify products that could have cumulative effects or support their safety concerning direct endocrine disruption capabilities.

show abstract

“…Findings have demonstrated connections between EED exposure and depression [12,13,14,15,16,17]. Based on discoveries that demonstrate that the Inhibitor of DNA-Binding/Differentiation (ID) proteins have been connected with depression [18,19,20,21,22], we will also emphasize how environmental EED exposure may modulate the depression outcomes via ID proteins. The goal of this review is to make links between ID proteins to EED interactions, thus, leading to altered results in depression.…”

Section: Introductionmentioning

confidence: 99%

Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction

Avecilla

2019

Medical Sciences

Self Cite

View full text Add to dashboard Cite

The ongoing growth of the international occurrence of depression and its ability to co-occur with other serious medical disorders, such as heart disease, cancer, diabetes, and Parkinson’s disease, is a current public health problem. Inhibitor of DNA-Binding/Differentiation (ID) proteins are part of a group of transcriptional factors that have shown involvement in neurocognitive disorders and, therefore, may have influence on depressive disorders. Previously, it has been established that exposure to environmental estrogenic endocrine disruptors (EEDs), such as polychlorinated biphenyls (PCBs) and bisphenol A (BPA), have played an important role in the modulation of depressive disorders. Hence, based on many studies, we consider the impact of these environmental pollutants on the group of ID proteins and how they impact depressive outcomes. Improved knowledge of how ID proteins interact with depressive disorders, through EED exposure, will contribute essential evidence that can further benefit our public health community with innovative knowledge to prevent these types of mental illnesses.

show abstract

Contribution of Inhibitor of Differentiation and Estrogenic Endocrine Disruptors to Neurocognitive Disorders

Cited by 6 publications

References 71 publications

Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

Endocrine Disruption by Mixtures in Topical Consumer Products

Inhibitor of DNA-Binding/Differentiation Proteins and Environmental Toxicants: Genomic Impact on the Onset of Depressive Dysfunction

Contact Info

Product

Resources

About