Contribution of Mass Spectrometry to the Study of Antimalarial Agents

Sitoe, Ana R.; Lopes, Francisca; Moreira, Rui; Coelho, Ana Silva; Bronze, Maria Rosário

doi:10.5772/56225

Cited by 3 publications

(1 citation statement)

References 44 publications

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“…Several qualitative and quantitative analytical methods have been reported for the analysis of artemisinin. These methods include high performance liquid chromatography [10], radioimmunoassay [11], enzyme‐linked immunosorbent assay [12], thin layer chromatography [13], gas chromatography [14] and mass spectrometry [15]. Nonetheless, these methods are expensive and time‐consuming as they involve several procedures.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

et al. 2022

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Solvothermally synthesized cobalt sulphide/reduced graphene oxide (CoS/rGO) was used to fabricate an electrochemical sensor for detection of artemisinin. Microscopic techniques were used to characterize CoS/rGO nanocomposite. The electrochemical sensor was fabricated by modifying the surface of glassy carbon electrode with CoS/rGO nanocomposite. [Fe(CN)6]3−/4− was used as a mediator to aid oxidation of artemisinin. Differential pulse voltammetric technique was used for the detection of artemisinin. A linear range of 30–100 μM was used. Experimentally, a detection limit of 0.5 μM was obtained. Therefore, the developed sensor can be used for quality control of artemisinin.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

et al. 2022

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Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

Madeira

Sitoe

Gonçalves

et al. 2014

J. Am. Soc. Mass Spectrom.

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The gas-phase behavior of 12 quinolon-4(1H)-imine derivatives with antiplasmodial activity was investigated using electrospray ionization tandem mass spectrometry together with collision induced dissociation and density functional theory (DFT) calculations. The most probable protonation site was predicted by calculating the proton affinity (PA) values for each possible protonation site and it was found to be the imine nitrogen for all compounds under study. Fragmentation pathways of the protonated molecules were proposed and the assignment of product ion structures was performed taking into account theoretical calculations. The nature of the quinoline substituent was found to influence the gas-phase behavior of the compounds under study. The data acquired allowed to bracket the proton affinity of the quinolin-4-imine scaffold, which can be a useful starting point to choose appropriate references for determining PA values of this scaffold.

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Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance

Tesfaselassie¹

2000

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Contribution of Mass Spectrometry to the Study of Antimalarial Agents

Cited by 3 publications

References 44 publications

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

Electrochemical Detection of Artemisinin Using Cobalt Sulphide/Reduced Graphene Oxide Nanocomposite

Antiplasmodial Drugs in the Gas Phase: A CID and DFT Study of Quinolon-4(1H)-Imine Derivatives

Antimalarial Drug Discovery using Triazoles to Overcome Chloroquine Resistance

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