Contribution of Sex and Genetics to Neuroendocrine Adaptation to Stress in Mice

Jones, Byron C.; Sarrieau, Alain; Reed, Cheryl; Azar, Marc R.; Mormède, Pierre

doi:10.1016/s0306-4530(98)00014-6

Cited by 63 publications

(58 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We further assessed basal plasma glucocorticoid levels in naïve mice of both strains determined as the total amount (free and protein bound) of the steroid hormone. Nominally, higher corticosterone concentrations were found in DBA/2 as compared to C57BL/6 animals, which, in turn, might reflect higher levels of free corticosterone in the jugular vein and previously reported higher levels of CBG in the DBA/2 strain (Jones et al, 1998).…”

Section: Article In Pressmentioning

confidence: 71%

“…Importantly, the observed strain differences in hippocampal versus jugular vein free corticosterone obtain special attention in the context of higher plasma corticosterone binding globuline (CBG) levels in DBA/2 than in C57BL/6 mice (Jones et al, 1998).…”

Section: Neuroendocrine Stress Responsesmentioning

confidence: 99%

“…It has been reported that C57BL/6 and DBA/2 mice display similar plasma corticosterone concentrations under basal conditions (Jones et al, 1998;McNamara et al, 2003), but marked differences under stress-related conditions. Cabib et al (1990) reported that C57BL/6 show a larger increase in plasma corticosterone levels than DBA/2 mice after a 30min exposure to an unfamiliar environment, with glucocorticoid concentrations returning back to basal values after 60 min in mice of the C57BL/6 strain and after 90 min in DBA/2 mice.…”

Section: Article In Pressmentioning

confidence: 99%

“…C57BL/6 and DBA/2 inbred mice have previously been used as a genetic animal model for anxiety-related and depression-like behavior (Crawley et al, 1997;Griebel et al, 1997;Ohl et al, 2003;Jacobson and Cryan, 2007) as well as a model of distinct hippocampal functioning regarding learning and memory (Ammassari-Teule et al, 2000;Passino et al, 2002). Moreover, it has been reported that mice of both strains show differences in glucocorticoid hormone responses towards stress but not under basal conditions (Cabib et al, 1990;Jones et al, 1998;McNamara et al, 2003;Shanks et al, 1990). However, the estimation of basal hormone action and HPA system regulation is rather complicated in these two inbred strains as they differ in their plasma concentrations of corticosterone binding globuline (Jones et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, it has been reported that mice of both strains show differences in glucocorticoid hormone responses towards stress but not under basal conditions (Cabib et al, 1990;Jones et al, 1998;McNamara et al, 2003;Shanks et al, 1990). However, the estimation of basal hormone action and HPA system regulation is rather complicated in these two inbred strains as they differ in their plasma concentrations of corticosterone binding globuline (Jones et al, 1998). This protein binds circulating corticosterone in the blood with less than 5% remaining unbound, i.e.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Thoeringer

Sillaber²,

Roedel

et al. 2007

Psychoneuroendocrinology

View full text Add to dashboard Cite

SummaryThere is strong evidence for a pivotal interaction of corticosteroid signalling and behavioral adaptation to stress. To further elucidate this relation, we monitored the dynamics of free corticosterone in the murine hippocampus of two inbred mouse strains using in vivo microdialysis. C57BL/6JOlaHsd (C57BL/6) and DBA/2OlaHsd (DBA/2) inbred mouse strains have been shown to differ in their anxiety-related and depression-like behavior and provide, thus, an interesting animal model to study the stimulus-response profile of the hypothalamus-pituitary-adrenocortical (HPA) system as a function of emotional and physical load. We, first, compared peripheral and intracerebral concentration patterns of corticosterone by simultaneous microdialysis of the jugular vein and the hippocampus in anesthetized mice and found strain differences in blood versus intracerebral free corticosterone concentrations. C57BL/6 showed almost the same steroid levels in either compartment, whereas DBA/2 mice displayed higher glucocorticoid levels in the circulation than in the hippocampus. This data suggest a strain difference in the tissue environment influencing the amount of biological active corticosterone at the receptor site. Measurements of intrahippocampal corticosterone in freely moving mice revealed that DBA/2 display a prolonged glucocorticoid increase in response to a single forced swimming stress (FST), as compared to C57BL/6 mice indicating a reduced inhibitory HPA axis feedback. Exposure to a novel environment (NE) induced a desensitization of the HPA system in DBA/2 animals as they show an attenuated intracerebral corticosterone dynamics after a subsequent FST. Testing animals in an elevated plus-maze (EPM), however, did not significantly stimulate coriticosterone release in either strain. The analysis of the area under the curve revealed a high amount of corticosterone released through FST and a low glucocorticoid release after NE or EPM exposure that are independent of the strain. This data indicate a strong stimulus dependency of corticosterone secretion that is strain independent, whereas the dynamics and feedback of the HPA axis is different between both inbred strains. Behavioral phenotyping of animals revealed a strong impact of microdialysis procedure on FST and EPM performance. Innate emotionality differences of both strains, however, were not affected. Though descriptive in nature, the present results suggest an altered corticosteroid signalling in the DBA/2 strain compared to C57BL/6 mice. Whether this observation causally underlies the differences in anxiety-related and depression-like behavior has to be further experimentally validated. In addition, our study highlights the use of in vivo microdialysis to assess the neuroendocrine endophenotype of animal models via profiling of stimulus-response patterns of stress hormones. ARTICLE IN PRESS

show abstract

Section: Article In Pressmentioning

confidence: 71%

Section: Neuroendocrine Stress Responsesmentioning

confidence: 99%

Section: Article In Pressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Thoeringer

Sillaber²,

Roedel

et al. 2007

Psychoneuroendocrinology

View full text Add to dashboard Cite

show abstract

Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing

Biag

Huang

Gou

et al. 2011

J of Comparative Neurology

190

182

View full text Add to dashboard Cite

The paraventricular nucleus of the hypothalamus (PVH) plays a critical role in the regulation of autonomic, neuroendocrine, and behavioral activities. This understanding has come from extensive characterization of the PVH in rats, and for this mammalian species we now have a robust model of basic PVH neuroanatomy and function. However, in mice, whose use as a model research animal has burgeoned with the increasing sophistication of tools for genetic manipulation, a comparable level of PVH characterization has not been achieved. To address this, we employed a variety of fluorescent tract tracing and immunostaining techniques in several different combinations to determine the neuronal connections and cyto- and chemoarchitecture of the PVH in the commonly used C57BL/6J male mouse. Our findings reveal a distinct organization in the mouse PVH that is substantially different from the PVH of male rats. The differences are particularly evident with respect to the spatial relations of two principal neuroendocrine divisions (magnocellular and parvicellular) and three descending preautonomic populations in the PVH. We discuss these data in relation to what is known about PVH function and provide the work as a resource for further studies of the neuronal architecture and function of the mouse PVH.

show abstract

Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing

Biag

Huang

Gou

et al. 2011

J of Comparative Neurology

View full text Add to dashboard Cite

A composite confocal photomicrograph showing the organization an topographic relations of specific neuronal populations in the hypothalamic paraventricular nucleus (PVH) of a C57BL/6malemouse. One population of PVH neurons (presumptive neuroendocrine) was identified by immunocytochemical detection of the retrograde tracer Fluorogold (FG; green) following its injection in to the tail vein; a second population of PVH neurons (presumptive preautonomic) was back‐labeled following upper thoracic level spinal cord injection of the retrograde tracer Fast Blue (FB; blue). Subsequently, distinct populations of oxytocin (OXY; red)‐ and vasopressin (VAS; magenta)‐ expressing neurons were identified immunocytochemically. At this PVH level neurons labeled only with FG (green) include numerous presumptive parvicellular neuroendocrine neurons. None of the FB (blue) back‐labeled neurons were immunopositive for OXY or VAS at this PVH level; however all of the OXY‐ and VAS immunopositive neurons were back‐labeled with FG, although the labeling intensity varied. Thus, OXY‐expressing FG labeled neurons appear red/yellow, whereas VAS‐expressing FG labeled neurons appear magenta/white. The Journal of Comparative Neurology, Volume 520, Number 1, pages 6–33.

show abstract

Contribution of Sex and Genetics to Neuroendocrine Adaptation to Stress in Mice

Cited by 63 publications

References 50 publications

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: An in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice

Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing

Cyto‐ and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: A study of immunostaining and multiple fluorescent tract tracing

Contact Info

Product

Resources

About