Contribution of the blood glucose level in perinatal asphyxia

Basu, Pallab; Som, Sabbasachi; Choudhuri, Nabendu; Das, Harendranath

doi:10.1007/s00431-008-0844-5

Cited by 71 publications

(52 citation statements)

References 11 publications

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“…Neonates with NE caused by HIE are at increased risk of depleting their energy stores and developing concurrent hypoglycemia. 4 When caring for infants with NE, is it important to identify the etiology and time of the brain injury and to predict neurodevelopmental outcome. 5,6 Neuroimaging with MR has been shown to be the ideal tool to demonstrate the extent of injury and predict outcome.…”

mentioning

confidence: 99%

“…[12][13][14] These studies also suggest that lower glucose levels are associated with a higher severity of encephalopathy and a worse outcome at 2 years. 4,14 Neuroimaging studies in neonatal hypoglycemia have shown a correlation between hypoglycemia, parieto-occipital injury, and involvement of the underlying white matter tracts, corpus callosum, and thalamus. 8,15,16 However, it is unclear whether the pattern of injury seen in HIE is modified by concurrent hypoglycemia and whether the effects of hypoglycemia in the context of HIE can be reliably recognized by imaging alone.…”

mentioning

confidence: 99%

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Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy

Wong¹,

Poskitt

Chau³

et al. 2013

AJNR Am J Neuroradiol

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confidence: 99%

mentioning

confidence: 99%

Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy

Wong¹,

Poskitt

Chau³

et al. 2013

AJNR Am J Neuroradiol

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“…52 Establishment of cerebral isoelectricity may be asynchronous, and this may explain asymmetric lesions in a given patient. 9,46 Contrary to the above observations, Schmidt et al 11 recently…”

mentioning

confidence: 82%

“…Hypoglycemia potentiates hypoxia-induced damage, and a combination of the 2 leads to worse outcomes than hypoxia alone. 4,46,47 These children often present with nonspecific symptoms such as seizures, lip-smacking, poor feeding, hypotonia, cyanosis, and vomiting. 4 There is scarce literature on perfusion imaging and spectroscopy findings in these patients.…”

Section: Neonatal Hypoglycemiamentioning

confidence: 99%

Neuroimaging in Patients with Abnormal Blood Glucose Levels

Bathla

Policeni

Agarwal

2013

American Journal of Neuroradiology

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SUMMARY:Smooth neuronal functioning requires an uninterrupted supply of energy that is provided by glucose under normal physiologic conditions. Significant variations in plasma glucose levels, be it hypoglycemia or hyperglycemia, can present with myriad clinical manifestations and may mimic stroke. At times, the diagnosis is either not apparent or not clinically suspected. Imaging can suggest the diagnosis in unsuspected cases and can help in the assessment of the extent of neuronal damage in known cases, making it vital for the neuroradiologist to be aware of both common and atypical neuroimaging findings in hypoglycemia and hyperglycemia.ABBREVIATIONS: GABA ϭ gamma aminobutyric acid; HC-HB ϭ hemichorea-hemiballismus; NIDDM ϭ non-insulin-dependent diabetes mellitus; NKHG ϭ non-

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“…En caso de hematocrito bajo el rango se corregir con transfusión de glóbulos rojos en alícuotas de 15 ml/kg. la hipoglicemia es un marcador de mal pronóstico, incluso más que el Apgar y la acidosis, por lo cual es fundamental mantener desde un comienzo glicemia estable entre 75-100 mg% [16][17] .…”

Section: Terapia De Rescateunclassified

Consenso sobre manejo integral del neonato con encefalopatía hipóxico isquémica

et al. 2012

Rev. chil. pediatr.

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Consensus statement on integral management of the newborn with hypoxic-ischemic encephalopathyNeonatal encephalopathy secondary to birth asphyxia, the hypoxic ischemic encephalopathy, remains a major cause of postnatal death and neurological sequelae worldwide. supportive therapy has been the mainstay of treatment. Recently series of multicenter clinical trials show the benefits of therapeutic hypothermia in this high risk population. The International liaison Committee on Resuscitation (IlCOR) has recommended hypothermia as a standard of care and a beneficial therapy using the protocols followed in large clinical trials. Our objective was to develop a practical guide to be used at a national level in Chile, compatible with published protocols and standardized on an international basis, practical and compatible with the country's situation, and considering an integral management of the asphyxiated neonates, rescue and neuroprotective therapies. In summary, to establish rescue therapies, with the aim objective of support measures that promote cerebral and systemic oxygenation/perfusion, ensuring optimal cellular homeostasis, which are the basis of the rescue measures in asphyxiated neonates. Along with these rescue therapies, the objective is to perform the more beneficial neuroprotective therapy known today, hypothermia. Hypothermia should be conducted in a level 3 Neonatal Intensive Care unit, with multidisciplinary care and standardized protocols and also multidisciplinary follow-up and rehabilitation therapies.

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Contribution of the blood glucose level in perinatal asphyxia

Abstract: The severity of encephalopathy and cellular damage varies with the severity of hypoglycemia.

Cited by 71 publications

References 11 publications

Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy

Brain Injury Patterns in Hypoglycemia in Neonatal Encephalopathy

Neuroimaging in Patients with Abnormal Blood Glucose Levels

Consenso sobre manejo integral del neonato con encefalopatía hipóxico isquémica

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