2012
DOI: 10.1016/j.mcna.2012.02.007
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Contribution of the Environment and Comorbidities to Chronic Obstructive Pulmonary Disease Phenotypes

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Cited by 36 publications
(28 citation statements)
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“…21 However, lack of impact of acculturation on HR-QOL in other respiratory diseases (eg, sleep disorders) has been reported by Soler et al 29 in a population-based survey comparing sleep quality between Mexican Americans and nonHispanic whites, and we found similar associations. Finally, based on interest in the association of comorbidities with poorer HR-QOL in COPD, 18,30 we also tested this variable as a signifi cant contributor to the ethnic diff erences, with negative results. Th us, aft er extensive analyses, only socioeconomic disparities were major contributors to the ethnic diff erences in HS in OLD.…”
Section: Discussionmentioning
confidence: 99%
“…21 However, lack of impact of acculturation on HR-QOL in other respiratory diseases (eg, sleep disorders) has been reported by Soler et al 29 in a population-based survey comparing sleep quality between Mexican Americans and nonHispanic whites, and we found similar associations. Finally, based on interest in the association of comorbidities with poorer HR-QOL in COPD, 18,30 we also tested this variable as a signifi cant contributor to the ethnic diff erences, with negative results. Th us, aft er extensive analyses, only socioeconomic disparities were major contributors to the ethnic diff erences in HS in OLD.…”
Section: Discussionmentioning
confidence: 99%
“…This finding is on par with the recognition of COPD as a major factor impacting health status at the population level, with associations also stronger than those reported for cardiovascular disease and diabetes (28). The biological plausibility of the COPDdisability association may be related to the idea that there are subgroups of subjects with COPD expressing more severe systemic consequences (29), probably mediated by systemic inflammatory pathways. However, although our findings are aligned with the current view of COPD as a disease with extrapulmonary effects, the elucidation of any mechanism involved is beyond the reach of this study.…”
Section: Discussionmentioning
confidence: 79%
“…When the presence of the disease is part of unique COPD phenotypes. 8 In keeping with these frameworks, we present those comorbidities which fulfill at least one of the characteristics. There is, however, significant heterogeneity in the definitions of each one of these studied diseases and the source of data used to evaluate the associations between it and COPD.…”
Section: Challenges In the Identification And Interpretation Of Copd mentioning
confidence: 99%
“…8 Burgel, et al, used hierarchical cluster analysis of data from more than 500 patients and detected 3 main groups: one with COPD but low burden of comorbidities; a second one with high risk of comorbidities with severe emphysema, low frequency of cardiovascular comorbidities and low BMI. ; and a third with high risk of mortality, mainly due to a high For personal use only.…”
Section: Comorbidity Clusters In Copd Phenotypesmentioning
confidence: 99%