Contribution of the parafascicular nucleus in the spontaneous object recognition task

Castiblanco-Piñeros, Edwin; Quiroz‐Padilla, María Fernanda; Cardenas-Palacio, Carlos Andres; Cárdenas, Fernando P.

doi:10.1016/j.nlm.2011.05.004

Cited by 6 publications

(3 citation statements)

References 89 publications

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“… 13 , 36 The Pf nucleus influences behavioral flexibility and is involved in object recognition tasks. 37 , 38 Although both nuclei were smaller in DS in our study cohort, the differences did not yield statistical significance.…”

Section: Discussioncontrasting

confidence: 73%

Volumetric differences of thalamic nuclei in children with trisomy 21

et al. 2023

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Objectives Histological studies have shown alterations of thalamic nuclei in patients with Down syndrome (DS). The correlation of these changes on MRI (magnetic resonance imaging) is unclear. Therefore, this study investigates volumetric differences of thalamic nuclei in children with DS compared to controls. Methods Patients were retrospectively identified between 01/2000 and 10/2021. Patient inclusion criteria were: (1) 0–18 years of age, (2) diagnosis of DS, and (3) availability of a brain MRI without parenchymal injury and a non-motion-degraded volumetric T1-weighted sequence. Whole thalamus and thalamic nuclei ( n = 25) volumes were analyzed bilaterally relative to the total brain volume (TBV). Two-sided t-tests were used to evaluate differences between groups. Differences were considered significant if the adjusted p-value was <0.05 after correction for multiple hypothesis testing using the Holm-Bonferroni method. Results 21 children with DS (11 females, 52.4%, mean age: 8.6 ± 4.3 years) and 63 age- and sex-matched controls (32 females, 50.8%, 8.6 ± 4.3 years) were studied using automated volumetric segmentation. Significantly smaller ratios were found for nine thalamic nuclei and the whole thalamus on the right and five thalamic nuclei on the left. TBV was significantly smaller in patients with DS ( p < 0.001). No significant differences were found between the groups for age and sex. Conclusions In this exploratory volumetric analysis of the thalamus and thalamic nuclei, we observed statistically significant volumetric changes in children with DS. Our findings confirm prior neuroimaging and histological studies and extend the range of involved thalamic nuclei in pediatric DS.

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Section: Discussioncontrasting

confidence: 73%

Volumetric differences of thalamic nuclei in children with trisomy 21

et al. 2023

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“…In this work, we identified specific brain cell types supporting a role of memory in obesity. First, the parafascicular nucleus (DEGLU4), when lesioned in mice, reduces object recognition memory 50 . Second, the retrosplenial cortex (TEGLU4) is responsible for decisions made on past experiences 51 .…”

Section: Evidence Supporting a Key Role Of The Learning And Memory Inmentioning

confidence: 99%

Mapping heritability of obesity by brain cell types

Thompson

Pers

2020

Preprint

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The underlying cell types mediating predisposition to obesity remain largely obscure. Here we first integrated recently published single-cell RNA-sequencing (scRNA-seq) data from >380 peripheral and nervous system cell types spanning 19 mouse organs with body mass index (BMI) genome-wide association study (GWAS) data from >450,000 individuals. Leveraging a novel strategy for integrating scRNA-seq data with GWAS data, we identified 22, exclusively neuronal, cell types from the subthalamus, midbrain, hippocampus, thalamus, cortex, pons, medulla, pallidum that were significantly enriched for BMI heritability (P<1.6x10 -4 ). Using genes harboring coding mutations leading to syndromic forms of obesity, we replicate four midbrain cell types from the anterior pretectal nucleus, superior nucleus, periaqueductal gray and pallidum (P<1.7x10 -4 ). Testing an additional set of 347 hypothalamic cell types, ventromedial hypothalamic steroidogenic-factor 1 (SF1) and cholecystokinin b receptor (CCKBR)-expressing neurons (P=4.9x10 -5 ) previously implicated in energy homeostasis and glucose control and three cell types from the preoptic area of the hypothalamus and the lateral hypothalamus enriched for BMI GWAS associations (P<4.9x10 -5 ).Together, our results suggest brain nuclei regulating integration of sensory stimuli, learning and memory are likely to play a key role in obesity and provide testable hypotheses for mechanistic follow-up studies.

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“…We have previously shown that PFn may play a modulatory role in cognitive functions as PFn DBS has a facilitating effect in memory tasks such as the two-way active avoidance task (Guillazo-Blanch et al, 1995;Sos-Hinojosa et al, 2003) and attenuates mnemonic deficits induced by the nucleus basallis magnocellularis lesion (Montero-Pastor et al, 2004). By contrast, lesion studies addressing the behavioural role of the PFn revealed impairments on several behavioural paradigms (Guillazo-Blanch et al, 1995;Quiroz-Padilla et al, 2006Castiblanco-Piñeros et al, 2011;Villarejo-Rodríguez et al, 2013).…”

Section: Discussionmentioning

confidence: 89%

Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex

et al. 2017

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The rodent parafascicular nucleus (PFn) or the centromedian-parafascicular complex of primates is a posterior intralaminar nucleus of the thalamus related to cortical activation and maintenance of states of consciousness underlying attention, learning and memory. Deep brain stimulation (DBS) of the PFn has been proved to restore arousal and consciousness in humans and to enhance performance in learning and memory tasks in rats. The primary expected effect of PFn DBS is to induce plastic changes in target neurons of brain areas associated with cognitive function. In this study, Wistar rats were stimulated for 20mins in the PFn following a DBS protocol that had previously facilitated memory in rats. NMDA and GABA receptor binding, and gene expression of the GluN1subunit of the NMDA receptor (NMDAR) were assessed in regions related to cognitive functions, such as the prefrontal cortex and hippocampus. The results showed that PFn DBS induced a decrease in NMDAR GluN1 subunit gene expression in the cingulate and prelimbic cortices, but no significant statistical differences were found in the density of NMDA or GABA receptors in any of the analyzed regions. Taken together, our findings suggest a possible role for the NMDAR GluN1 subunit in the prefrontal cortex in the procognitive actions of the PFn DBS.

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Contribution of the parafascicular nucleus in the spontaneous object recognition task

Cited by 6 publications

References 89 publications

Volumetric differences of thalamic nuclei in children with trisomy 21

Volumetric differences of thalamic nuclei in children with trisomy 21

Mapping heritability of obesity by brain cell types

Parafascicular thalamic nucleus deep brain stimulation decreases NMDA receptor GluN1 subunit gene expression in the prefrontal cortex

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