Contribution to investigation of antimicrobial activity of styrylquinolines

8‐Hydroxyquinoline‐2‐Carboxanilides as Antiviral Agents Against Avian Influenza Virus

“…This study is a follow‐up contribution to previously published papers,,, investigating a compound library comprising 8‐hydroxyquinolinecarboxanilides to counteract the deadly H5N1 virus. Based on the results of the primary screening of a mono‐substituted anilides as an original series, it was completed by specifically designed new di‐ and tri‐substituted anilides, and the structure–activity relationships (SAR) of all the mentioned compounds have been investigated.…”

Ring-substituted 8-hydroxyquinoline-2-carboxanilides as potential antimycobacterial agents

“…[9][10][11]35,36,43 This is probably caused by the fact that between the hydroxyl moiety in C (8) of the quinoline nucleus and nitrogen of quinoline intramolecular H-bond affecting lipophilicity, solubility and basicity/acidity is formed. 44 Based on the presented results, it can be stated that log k values specify lipophilicity within individual series of the studied compounds better than log P values.…”

“…The quinoline nucleus can be considered as a privileged structure; 5 quinoline-based compounds exhibit various activities such as anti-inflammatory, cardiovascular, anticonvulsant, antiproliferative, antiprotozoan, antifungal and antibacterial. [6][7][8][9][10][11][12] Quinoline analogues [6][7][8]13,14 and especially 8-hydroxyquinolines have been also recognized as promising antimycobacterial agents. [15][16][17][18] The best known quinoline anti-TB derivative, bedaquiline (Sirturo™) belonging to diarylquinolines, a new class of antitubercular drugs, was approved by FDA for treatment of MDR-TB.…”

“…[15][16][17][18] The aim of this contribution is synthesis and antimycobacterial screening of 8-hydroxyquinoline-2-carboxanilides with following analysis of the structure-activity relationships as a continuation of the investigation of recently designed ring-substituted quinoline analogues. [9][10][11][34][35][36][37] Based on the above mentioned facts all the presented compounds were designed to bear an 8-hydroxyquinoline fragment and an amide moiety. Both structural features are important functional groups that are able to interact with a number of enzymes/receptors via hydrogen bonds and in this manner to affect the biological response.…”

Preparation and Herbicidal Activity of Halogenated 8-Hydroxyquinoline-2-carboxanilides

“…A quinoline scaffold possesses unique physico-chemical properties and therefore it is present in many classes of biologically-active compounds expressing diverse effects [1][2][3][4][5][6]. In addition, according to the results reported recently, some quinoline derivatives and their analogues/isosteres also showed noteworthy herbicidal activities [7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”