Contributions of temporal-parietal junction to the human auditory P3

Knight, Robert T.; Scabini, Donatella; Woods, David L.; Clayworth, C. C.

doi:10.1016/0006-8993(89)90466-6

Cited by 479 publications

(249 citation statements)

References 31 publications

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“…The superior temporal gyrus (STG), to which P300 has been associated (e.g., Knight et al, 1989), is one of the last brain regions to mature. Indeed, the physiological decrease in gray matter in this area seems to start close to 20 years of age in normal subjects (Lenroot and Giedd, 2006;Giedd et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

P300 asymmetry and positive symptom severity: A study in the early stage of a first episode of psychosis

Renoult

Prévost

Brodeur

et al. 2007

Schizophrenia Research

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The amplitude of the P300 event-related potential (ERP) has been reported to be reduced over left compared to right temporal sites in schizophrenia patients. This left temporal P300 reduction has been associated with positive symptom severity and gray matter reduction in the left superior temporal gyrus. We investigated a group of patients with a first episode of schizophrenia spectrum psychosis and a group of normal controls to verify if P300 amplitude asymmetry already exists around the time of presentation for treatment. Relative to normal control subjects, no P300 asymmetry was found in patients. Nevertheless, P300 asymmetry was correlated with the severity of positive symptoms and worse global functioning (GAF), a good predictor of poor outcome.

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Section: Discussionmentioning

confidence: 99%

P300 asymmetry and positive symptom severity: A study in the early stage of a first episode of psychosis

Renoult

Prévost

Brodeur

et al. 2007

Schizophrenia Research

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“…Lesions studies have shown that damage to the temporo-parietal junction including posterior hippocampus, posterior temporal plane, superior temporal sulcus, anterior and medial temporal lobe all result in significant reductions of the scalp-recorded P3b (Knight, 1996;Knight et al, 1989;Onofrj et al, 1992;Verleger et al, 1994). Intracranial recording studies have also implicated similar regions in generation of the scalp-P3b (Halgren et al, 1995a,b;McCarthy et al, 1989;Smith et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy

Chao

Lindgren

Flenniken

et al. 2004

Clinical Neurophysiology

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Objective-To examine the effects of human immunodeficiency virus (HIV) on central nervous system (CNS) function in patients receiving antiretroviral therapy (ART) who have suppressed viral loads.Methods-Event-related brain potentials (ERPs) were recorded from 15 virally suppressed HIV patients and 15 age-, sex-, and education-matched controls while they performed a 3-stimulus auditory oddball task. The amplitude and latency of the P3a, P3b, and early auditory components were examined in HIV patients and controls.Results-Virally suppressed HIV patients on ART were more depressed than controls, as determined by the Beck Depression Inventory (BDI). After controlling for the effects of depression, HIV patients had smaller P2, P3a, and P3b amplitudes and longer P3a and P3b latency than control subjects. BDI scores correlated positively with N1 latency in HIV patients and negatively with P3b amplitude in all subjects.Conclusions-These electrophysiological results suggest that, even in the absence of detectable levels of HIV in the peripheral blood, viral replication persists in the CNS and continues to cause disease in HIV patients on ART.

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“…Indeed, assessment of patients with bilateral hippocampal lesions without surgical intervention demonstrated no reliable P300 differences relative to controls (Polich and Squire, 1993). P300 amplitude is affected by temporal-parietal junction integrity as its absence greatly reduces component size over the parietal area (Knight et al, 1989;Verleger et al, 1994;Yamaguchi and Knight, 1992). This connection implies that the P3a and P3b indicate a circuit pathway between frontal and temporal/parietal brain areas (Soltani and Knight, 2000;Polich, 2003).…”

Section: Neural Origins Of P3a and P3bmentioning

confidence: 99%

Updating P300: An integrative theory of P3a and P3b

Polich

2007

Clinical Neurophysiology

6,455

458

6,265

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The empirical and theoretical development of the P300 event-related brain potential (ERP) is reviewed by considering factors that contribute to its amplitude, latency, and general characteristics. The neuropsychological origins of the P3a and P3b subcomponents are detailed, and how target/ standard discrimination difficulty modulates scalp topography is discussed. The neural loci of P3a and P3b generation are outlined, and a cognitive model is proffered: P3a originates from stimulusdriven frontal attention mechanisms during task processing, whereas P3b originates from temporalparietal activity associated with attention and appears related to subsequent memory processing. Neurotransmitter actions associating P3a to frontal/dopaminergic and P3b to parietal/norepinephrine pathways are highlighted. Neuroinhibition is suggested as an overarching theoretical mechanism for P300, which is elicited when stimulus detection engages memory operations.

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Contributions of temporal-parietal junction to the human auditory P3

Cited by 479 publications

References 31 publications

P300 asymmetry and positive symptom severity: A study in the early stage of a first episode of psychosis

P300 asymmetry and positive symptom severity: A study in the early stage of a first episode of psychosis

ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy

Updating P300: An integrative theory of P3a and P3b

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