ERP evidence of impaired central nervous system function in virally suppressed HIV patients on antiretroviral therapy

Chao, Li-Lian; Lindgren, Joselyn; Flenniken, Derek; Weiner, Michael W.

doi:10.1016/j.clinph.2004.02.015

Cited by 33 publications

(27 citation statements)

References 58 publications

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“…This data agrees with the research by Chao et al (25) that also found disorders in this potential with HIV/AIDS individuals. According to Picton (18) the P300 amplitude is not a reliable parameter to compare the potentials between two groups because it may influenced by attention factors.…”

Section: Discussionsupporting

confidence: 83%

Potenciais evocados auditivos de longa latência em adultos com HIV/Aids

Silva

Pinto²,

Matas

2007

Pró-Fono R. Atual. Cient.

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Background: Long Latency Auditory Evoked Potentials. Aim: to characterize the Long Latency Auditory Evoked Potentials (LLAEP) in individuals with HIV/AIDS in comparison to a control group. Method: the research sample was composed by 21 individuals with HIV/AIDS -research group (14 male and 7 female), with ages ranging from 31 to 48 years, and 21 healthy individuals -control group (5 male and 16 female), with ages ranging from 19 to 36 years. The latency and amplitude values of the P300 wave were analyzed; latency of N1 and P2 waves, and amplitude N1-P2. The electrodes were placed on the following positions: A1, A2, Cz and Fpz. Results: the T-student test was used to analyze the results and the adopted significance level was of 5%. In the analyzes of P300 it was observed that the group with HIV/AIDS presented greater latency values (p-value = 0,010) and lower amplitude values (p-value = 0,021) when compared to the control group. The analysis of the N1-P2 complex revealed that the research group presented higher latency values for both, N1 wave (p-value = 0,035) and P2 wave, however for this last one, there was no significant statistical difference when compared to the control group. Concerning the amplitude analysis of the N1-P2 complex, it was verified that the control group presented significantly higher values when compared to the research group. Conclusion: the findings of this study indicates that individuals with HIV/AIDS present alterations in the Long Latency Auditory Evoked Potentials (higher latencies and lower amplitudes of N1, P2 and P300 waves), suggesting a disorder in the cortical regions of the auditory pathway, and therefore stressing the importance of such tests in the evaluation of these individuals.

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Section: Discussionsupporting

confidence: 83%

Potenciais evocados auditivos de longa latência em adultos com HIV/Aids

Silva

Pinto²,

Matas

2007

Pró-Fono R. Atual. Cient.

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“…Several studies have documented disorders in the auditory evoked potentials of patients with AIDS (Martin et al, 2001;Polich & Basho, 2002;Chao et al, 2004;Tartar et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Potenciais evocados auditivos de média e longa latências em adultos com AIDS

Matas

Juan

Nakano

2006

Pró-Fono R. Atual. Cient.

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Background: middle and late latency auditory evoked potentials. Aim: to verify the occurrence of middle and late latency auditory evoked potentials disorders in adults with Acquired Immunodeficiency Syndrome (AIDS). Method: middle and late latency auditory evoked potentials of 8 individuals with AIDS, with ages ranging from 10 to 51 years, with normal hearing, or with sensoryneural hearing losses up to moderate, and normal results in the Auditory Brainstem Response, comparing the results with the responses obtained for a control group which was composed by 25 individuals, with ages ranging from 19 to 24 years, with no hearing complaints and with normal hearing and normal results in the Auditory Brainstem Response. Results: the Pa wave latency and amplitude averages in the C3/A2 and C4/A1 modalities, and the average of the P300 wave were analyzed. No significant differences were observed in the Pa wave amplitude and latency averages between the groups, although a non-statistically significant increase was observed in the latency and a decrease in the amplitude of such wave for the research group in the C3/A2 modality. The latency of the P300 wave was significantly longer to the left for the research group. It was also observed a longer latency to the right, although this was not statistically significant. Conclusion: adult individuals with AIDS do not present alterations in the middle latency auditory evoked potential and do present alterations in the cognitive potential, indicating a disorder in the cortical regions of the auditory pathway and a deficit in the cognitive processing of auditory information for this population. Such findings stress the importance of a careful investigation of the auditory function of individuals with AIDS, thus favoring the therapeutic planning.

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“…Before higher level cognitive symptoms manifest, the early stages of HIV-1 may be marked by alterations in temporal processing, as assessed with amplitude and latency measures of auditory evoked potentials (AEPs), both without (Castello et al 1998;Fein et al 1995;Gil et al 1992;Koralnik et al 1990;Pagano et al 1992;Schroeder et al 1996;Vigliano et al 2000), and after, CART initiation (Chao et al 2004;Matas et al 2010). Simian and feline immunodeficiency virus models have also demonstrated alterations in evoked potentials (Phipps et al 2000;Prospero-Garcia et al 1999;Raymond et al 1998;Riazi et al 2009).…”

Section: Introductionmentioning

confidence: 99%