Potenciais evocados auditivos de longa latência em adultos com HIV/Aids

Abstract

Background: Long Latency Auditory Evoked Potentials. Aim: to characterize the Long Latency Auditory Evoked Potentials (LLAEP) in individuals with HIV/AIDS in comparison to a control group. Method: the research sample was composed by 21 individuals with HIV/AIDS -research group (14 male and 7 female), with ages ranging from 31 to 48 years, and 21 healthy individuals -control group (5 male and 16 female), with ages ranging from 19 to 36 years. The latency and amplitude values of the P300 wave were analyzed; latency of N1 and P2 waves, and amplitude N1-P2. The electrodes were placed on the following positions: A1, A2, Cz and Fpz. Results: the T-student test was used to analyze the results and the adopted significance level was of 5%. In the analyzes of P300 it was observed that the group with HIV/AIDS presented greater latency values (p-value = 0,010) and lower amplitude values (p-value = 0,021) when compared to the control group. The analysis of the N1-P2 complex revealed that the research group presented higher latency values for both, N1 wave (p-value = 0,035) and P2 wave, however for this last one, there was no significant statistical difference when compared to the control group. Concerning the amplitude analysis of the N1-P2 complex, it was verified that the control group presented significantly higher values when compared to the research group. Conclusion: the findings of this study indicates that individuals with HIV/AIDS present alterations in the Long Latency Auditory Evoked Potentials (higher latencies and lower amplitudes of N1, P2 and P300 waves), suggesting a disorder in the cortical regions of the auditory pathway, and therefore stressing the importance of such tests in the evaluation of these individuals.

Long-latency auditory evoked potentials: Normalization of protocol applied to normal adults

“…These results agree with the study by Pinzan-Faria [22], where the average for ears with normal thresholds was 6.47uV. However, our results disagree with the study by Silva, Pinto and Matas [23], in which the mean amplitude for individuals without central alterations was 10.6uV. Picton [24] notes that the amplitude of P3 is variable due to the different levels of attention during the examination.…”

Saúde auditiva, o vírus da imunodeficiência humana e a síndrome da imunodeficiência adquirida: uma revisão

“…Um segundo subtema abordado envolve a AIDS ou o HIV como fatores de risco para patologias auditivas. Nos Estados Unidos, o National Institutes of Health estima que 75% dos adultos portadores da AIDS têm algum tipo de distúrbio auditivo, causado pela própria doença, por infecções oportunistas ou por tratamentos com medicações ototóxicas [17][18][19][20][21][22] .…”

“…Num estudo similar, Silva et al 22 avaliaram 21 indivíduos com HIV/AIDS e observaram alterações nos parâmetros de amplitude e de latência na avaliação do P300. No complexo N1-P2, verificou-se amplitude reduzida e latência aumentada na onda N1.…”

Editorial

“…The purpose of the study presented by Silva et al (2007) was to characterize the Long Latency Auditory Evoked Potentials (LLAEP) in 21 individuals with HIV/AIDS in comparison to a control group. The findings of this study suggest that individuals with HIV/AIDS present a disorder in the cortical regions of the auditory pathway, indicating the importance of such tests in the evaluation of these individuals.…”