Contributions of the GABAergic system of the prelimbic cortex and basolateral amygdala to morphine withdrawal-induced contextual fear

Seno, F Z; Sgobbi, R F; Nobre, Manoel Jorge

doi:10.1016/j.physbeh.2022.113868

Cited by 4 publications

(1 citation statement)

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“…Opioid receptors moderate the activity of GAD67 in the hippocampus [92], following changes in the levels of GABA released from presynaptic terminals (Table 1). This modulation may be involved in antidepressant-related mechanisms through KORs [91], addiction (dependence on opioid drugs), and anxiolytic mechanisms, particularly in the prelimbic cortex and the amygdala [144]. Calaj et al ( 2020) indicated that GAD67-expressing interneurons in the VTA, a key area involved in reward processing, may also modulate the activity of the opioid system through their GABAergic inhibitory inputs [145].…”

Section: Opioids and Glutamate Decarboxylase 65/67mentioning

confidence: 99%

Shared Mechanisms of GABAergic and Opioidergic Transmission Regulate Corticolimbic Reward Systems and Cognitive Aspects of Motivational Behaviors

et al. 2023

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The functional interplay between the corticolimbic GABAergic and opioidergic systems plays a crucial role in regulating the reward system and cognitive aspects of motivational behaviors leading to the development of addictive behaviors and disorders. This review provides a summary of the shared mechanisms of GABAergic and opioidergic transmission, which modulate the activity of dopaminergic neurons located in the ventral tegmental area (VTA), the central hub of the reward mechanisms. This review comprehensively covers the neuroanatomical and neurobiological aspects of corticolimbic inhibitory neurons that express opioid receptors, which act as modulators of corticolimbic GABAergic transmission. The presence of opioid and GABA receptors on the same neurons allows for the modulation of the activity of dopaminergic neurons in the ventral tegmental area, which plays a key role in the reward mechanisms of the brain. This colocalization of receptors and their immunochemical markers can provide a comprehensive understanding for clinicians and researchers, revealing the neuronal circuits that contribute to the reward system. Moreover, this review highlights the importance of GABAergic transmission-induced neuroplasticity under the modulation of opioid receptors. It discusses their interactive role in reinforcement learning, network oscillation, aversive behaviors, and local feedback or feedforward inhibitions in reward mechanisms. Understanding the shared mechanisms of these systems may lead to the development of new therapeutic approaches for addiction, reward-related disorders, and drug-induced cognitive impairment.

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