“Control” and Diabetes

Cahill, George F.; Etzwiler, Donnell D.; Freinkel, Norbert

doi:10.1056/nejm197604292941811

Cited by 302 publications

(65 citation statements)

References 6 publications

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“…In insulin-treated diabetic patients who nowadays hope for a long life expectancy without physiological or social handicaps, an improvement of control will probably be beneficial in lowering the occurrence and severity of microangiopathy [15], although the relationship between blood glucose control and the evolution of microvascular disease in diabetes is still under discussion [1,2]. The results of this study may indicate that the desire for better control does not increase the social restrictions placed on the diabetic or the risk of more frequent hypoglycaemic reactions.…”

Section: Discussionmentioning

confidence: 99%

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The risk of diabetic control: A comparison of hospital versus general practice supervision

Basdevant

Costagliola

et al. 1982

Diabetologia

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Summary. Two groups of insulin-treated outpatients (one followed up at the Hotel-Dieu Hospital and the second mainly supervised by general practitioners) were chosen at random in 1978. The two populations were comparable in age, age at diagnosis, sex, level of education, overall activity and socio-professional and economic status. Outpatients followed up in the diabetic unit had better blood glucose control, with about the same number of hypoglycaemic reactions as patients followed up in general practice. This better control was associated with more social activity and less visits to the physician, despite the fact that patients attending the hospital spent more money on their diet and had more daily insulin injections. All these differences remain significant after adjustment for the duration of diabetes. It may be inferred that attempts to improve control in insulin-treated patients are associated with a more active life and with no increase in the frequency of hypoglycaemic reactions.

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Section: Discussionmentioning

confidence: 99%

“…Following several controversial publications on the control of diabetes [1,2], Ingelfinger [3] stressed that 'almost nothing is known of the risks, in particular hypoglycaemia, of attempting to implement control'.…”

mentioning

confidence: 99%

The risk of diabetic control: A comparison of hospital versus general practice supervision

Basdevant

Costagliola

et al. 1982

Diabetologia

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“…Although it is generally believed that a strict metabolic control delays the development of late complications in diabetes mellitus [15]. Type 2 Diabetes mellitus and metabolic syndrome are important risk factors for atherosclerosis and further complications [16].…”

Section: Introductionmentioning

confidence: 99%

Trace Elements in Diabetes Mellitus

Praveeena¹,

Pasula²,

K³

2013

JCDR

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Introduction: Diabetes Mellitus is the commonest major metabolic disease and most prevalent diseases worldwide. Its related morbidity is due to its micro and macro angiopathic complications. Aim:The aim of this study was to measure and compare the serum levels of zinc and magnesium in normal individuals and in diabetic patients.Method: Analysis of minerals was done in plasma by using a Varian Spectra AA 220 model atomic absorption spectrophotometer. Result:Our observations showed a definite lowering of serum magnesium (p<0.001) and serum zinc levels (p<0.001) were significant in diabetic group. Conclusion:The cause of diabetic hypomagnesaemia is multifactorial. An altered metabolism, a poor glycaemic control and osmotic diuresis may be contributory factors. Decreased serum zinc levels in diabetes may be caused by an increase in urinary loss. These decreased levels of trace elements cause disturbances in glucose transport across cell membrane lead to insufficient formation and secretion of insulin by pancreas which compromise in the antioxidant defense mechanisms.

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“…They lacked the technology to do better. Despite so much uncertainty, experience suggested that the laissez-faire approach was harmful [39], and the balance of opinion reached its tipping point with a celebrated debate in the New England Journal of Medicine in 1976 [40]. The 60-year-old argument was not finally resolved until the results of the Diabetes Control and Complications Trial were published in 1993 [41] and confirmed the influence of glucose control upon microvascular complications beyond dispute; its relation to arterial disease still gives rise to some controversy.…”

Section: Control and Complicationsmentioning

confidence: 99%