Diet, delusion and diabetes

Sawyer, L.; Gale, E. A. M.

doi:10.1007/s00125-008-1203-9

Cited by 33 publications

(28 citation statements)

References 33 publications

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“…diet and physical activity. Dietary compliance must return to its proper place as a cornerstone of diabetes therapy [22], while the practice of compensating for dietary indiscretions with increasing doses of insulin should be discouraged.…”

Section: Merriam-webster Dictionary 11th Edition (1977)mentioning

confidence: 99%

Mitogenic action of insulin: friend, foe or ‘frenemy’?

Draznin

2009

Diabetologia

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Either endogenous or exogenous hyperinsulinaemia in the setting of insulin resistance promotes phosphorylation and activation of farnesyltransferase, a ubiquitous enzyme that farnesylates Ras proteins. Increased availability of farnesylated Ras at the plasma membrane enhances mitogenic responsiveness of cells to various growth factors, thus contributing to progression of cancer and atherosclerosis. This effect is specific to insulin, but is not related to the type of insulin used. The stimulatory effect of hyperinsulinaemia on farnesyltransferase in the presence of insulin resistance represents one potential mechanism responsible for mitogenicity and atherogenicity of insulin.

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Section: Merriam-webster Dictionary 11th Edition (1977)mentioning

confidence: 99%

Mitogenic action of insulin: friend, foe or ‘frenemy’?

Draznin

2009

Diabetologia

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“…The proper amounts and types of carbohydrates have been an area of persistent controversy in the management of T2DM. Before the availability of insulin, a low-calorie diet, based on a strict restriction of carbohydrate intake and an increased intake of dietary fat, was recommended [1,2]. The discovery of insulin allowed for a higher carbohydrate diet.…”

Section: Introductionmentioning

confidence: 99%

Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Jung

Choi

2017

Nutrients

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In patients with type 2 diabetes mellitus (T2DM), whether dietary carbohydrates have beneficial or detrimental effects on cardiometabolic risk factors has drawn attention. Although a high-carbohydrate (HC) diet and a low-carbohydrate (LC) diet have gained popularity for several decades, there is scarce review focusing on the effects of HC diet on glucose, lipids and body weight in patients with T2DM. In this review, we examined recently-published literature on the effects of HC diets on metabolic parameters in T2DM. HC diets are at least as effective as LC diets, leading to significant weight loss and a reduction in plasma glucose, HbA1c and low density lipoprotein-cholesterol (LDL-C) levels. The major concern is that HC diets may raise serum triglyceride levels and reduce high density lipoprotein-cholesterol (HDL-C) levels, increasing the risk of cardiovascular disease. However, these untoward effects were not a persistent consequence and may be ameliorated with the consumption of a low glycemic index (GI)/low glycemic load (GL) and high fiber. Carbohydrate intake should be individualized, and low caloric intake remains a crucial factor to improve insulin sensitivity and reduce body weight; however, an HC diet, rich in fiber and with a low GI/GL, may be recommendable in patients with T2DM.

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“…5 The World Health Organization, American Diabetes Association and Diabetes Canada all maintain that lifestyle therapy is the cornerstone of management; however, there remains no consensus about an optimal diet for T2D. 6,7,8,9 Many diets have been tested including various restrictions on calories, carbohydrates and dietary fat. Low-fat diets appear to be ineffective as a treatment for T2D.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic fasting as a potential effective treatment for type 2 diabetes: A 4-month case study

Ku¹,

Ramos²,

Fung³

2017

JMH

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Lifestyle therapy is an integral part of type 2 diabetes (T2D) management, but there remains no consensus on an optimal diet. The objective of this study is to evaluate the efficacy of therapeutic fasting as a treatment for T2D. This case follows a male T2D patient treated at the Intensive Dietary Management Clinic in Scarborough, Ontario, over a 4-month period. The patient’s initial fasting regimen consisted of a 24-h fast, three times a week. Over the course of treatment, the patient gradually extended his fasting period, eventually fasting for 42 h, two to three times a week. By the end of treatment, the patient’s weight was reduced by 17.8% and his waist circumference was reduced by 11.0%. In addition, the patient’s glycated haemoglobin levels decreased from 7.7% to 7.2%, and he was able to completely discontinue his insulin treatment, despite over a decade of insulin usage. The patient did not find it difficult to adhere to the fasting schedule and did not experience any hypoglycaemic episodes or other significant adverse effects. These observations suggest that therapeutic fasting may be a viable treatment option for T2D patients.

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Diet, delusion and diabetes

Cited by 33 publications

References 33 publications

Mitogenic action of insulin: friend, foe or ‘frenemy’?

Mitogenic action of insulin: friend, foe or ‘frenemy’?

Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Therapeutic fasting as a potential effective treatment for type 2 diabetes: A 4-month case study

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