Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Jung, Chan‐Hee; Choi, Kyung Mook

doi:10.3390/nu9040322

Cited by 91 publications

(84 citation statements)

References 96 publications

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“…Previous study suggested that the magnitude of postprandial responses to mixed meals depended largely on the total amount of fat and carbohydrates intakes 1,5,6 .The American Diabetes Association (ADA) recommends monitoring carbohydrate intake to achieve better glycemic control in patients with type 2 diabetes, which is based on studies showing reduced postprandial glucose and triglyceride responses in individuals consuming HF-LC diets [34][35][36] . However, previous systematic reviews discussed the effects of HF-LC and LF-HC diets on metabolic risk factors and showed inconsistent results 5,7,37 .…”

Section: Discussionmentioning

confidence: 99%

Application of n-of-1 clinical trials in personalized nutrition research: a trial protocol for Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)

Tian

et al. 2020

Preprint

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IMPORTANCE Diet and nutrition play essential roles in human health. Personalized dietary recommendations or nutritional advice tailored to each individual can help with more effective disease prevention. N-of-1 trials can provide a pragmatic clinical means of addressing individual postprandial blood glucose variation in response to different food ingredients or nutrients. OBJECTIVE To investigate the individual postprandial glucose response to diets with diverse macronutrient proportions at both individual level and population level and the potential of the novel single-patient (n-of-1) trial for the personalization of diet. DESIGN Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR) is a multiple crossover feeding trial. Individual response to different dietary patterns in terms of postprandial glucose response is the primary outcome. Secondary outcomes include individual phenotypic response and the effects of dietary ingredients on the composition and structure of gut microbiota. SETTING Participants experience three successive 12-day dietary intervention pairs including a 6-day wash-out period before each isocaloric dietary intervention. Two different type of diets (a 6-day high-fat, low-carbohydrate (HF-LC) diet and a 6-day low-fat, high-carbohydrate (LF-HC) diet) are assigned to an individual in a randomized sequence using block randomization with a fixed block size of two. This feeding trial takes place in Hangzhou, China. PARTICIPANTS Target enrolment is 30 healthy individuals aged between 18 and 65 years. Exclusion criteria are inability or unwillingness to approved informed consent; other serious medical conditions; food allergy; and no access to a smart phone or computer with an internet connection. DISCUSSION This trial addresses the feasibility of n-of-1 approach for personalizing dietary intervention to individuals. The results will help provide personalized dietary recommendation on macronutrients in terms of postprandial blood glucose response. Well-designed n-of-1 trial is likely to become an effective method of optimizing individual health and advancing health care. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT04125602

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Section: Discussionmentioning

confidence: 99%

Application of n-of-1 clinical trials in personalized nutrition research: a trial protocol for Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)

Tian

et al. 2020

Preprint

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“…Fiber has been known to have an effect on improve lipid profile and a diet rich in fiber with a low glycemic index (GI)/low glycemic load (GL) may be recommendable in patients with T2DM [18]. Eating at least 22 g/day fiber may reduce total cholesterol and LDL in healthy premenopausal women, and estradiol may slightly reduce the effect [19].…”

Section: Discussionmentioning

confidence: 99%

Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

Sunarti

Rini

Sinorita

et al. 2018

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and aims: High levels of non-HDL and atherogenic cholesterol can induce inflammation, and as risk factor for cardiovascular diseases. This study was to evaluate the effects of fiber-rich snacks on non-HDL cholesterol, atherogenic index, and C-reactive protein (CRP) levels in type 2 diabetes patients (T2DM). Material and Methods: Twenty T2DM patients, were recruited from the Policlinic of Endocrine, Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The subjects received daily 32g fiber-rich snacks made of Dioscorea esculenta, arrowroot, cassava and pumpkin for 4 weeks. Fasting non-HDL cholesterol, atherogenic index, CRP and HbA1c levels were measured before and after intervention. Paired t-test was used to evaluate the results. Results: The fiber-rich snack intervention in T2DM patients significantly reduced levels of non-HDL cholesterol and CRP levels (p<0.05), but the decreased the atherogenic index was not significant (p>0.05). The intervention also significantly reduced the CRP levels (p<0.05) but did not affect HbA1c levels. Body weight, body mass index (BMI), waist circumference decreased significantly after consuming the snacks (p<0.05). Conclusions: This study showed fiber-rich snack has a positive effect in improving non-HDL cholesterol, atherogenic index and CRP levels but does not affect HbA1c levels in T2DM patients.

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“…Hal ini juga sesuai dengan penelitian sebelumnya yang melihat hubungan konsumsi karbohidrat dan serat terhadap kadar glukosa darah. (28) Kadar insulin post-test pada penelitian ini, tidak memiliki perbedaan yang bermakna antar kelompok. Pada penelitian ini kadar insulin masing-masing kelompok normal yaitu antara 0,3-1,4 ng/ml.…”

Section: Pembahasanunclassified

Pengaruh yoghurt dan soyghurt kayu manis (Cinnamomum burmannii) terhadap kadar glukosa darah, insulin serum, dan malondialdehyde tikus pra sindrom metabolik

Rustanti

Nafsih

Avisha

et al. 2020

JGI

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Background: Pre metabolic syndrome is characterized by two of five risk factors: central obesity, dyslipidemia, hypertension, and increased fasting blood glucose. Cinnamon yogurt and soygurt contain antioxidants and fiber which can improve insulin sensitivity and blood glucose homeostasis and prevent cell damage in pre-metabolic syndrome conditionsObjective: This study aimed to determine the effect of cinnamon yogurt and soygurt on fasting blood glucose (FBG), serum insulin, and malondialdehyde (MDA) levels in pre-metabolic syndrome rats.Method: This study was an experimental study with a pre and post-test control group design. The subjects were 15 male Sprague Dawley rats which were divided into 5 normal control mice (K) and 10 pre metabolic syndrome mice with a diet high in fat and fructose for group P1 (yogurt) and P2 (soygurt) each of 5 mice. The yogurt and soygurt were given as much as 3.4 ml / g BW for 28 days. FBG levels were measured by the GOD-PAP method, while serum insulin and MDA levels were by the ELISA method. Different tests before and after treatment using Paired t-test or Wilcoxon. The difference tests between groups using the One-Way ANOVA test or Kruskal Wallis.Results: There were no differences in FBG and MDA levels between groups after intervention (p> 0.05). The highest percentage reduction in FBG in the P2 (-11.59%), then P1 (-4.06%). The decrease in MDA levels in group P1 = 19.17%, and P2 = 15.44% lower than K = 24.43%. After the intervention, the insulin level in group P2 (0.46 ng / ml) was significantly higher than P1 (0.318 ng/ml), but both were not different from K (0.384 ng / ml).Conclusion: There was no significant effect on the administration of cinnamon yogurt and soygurt to FBG, serum insulin, and MDA levels.

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Impact of High-Carbohydrate Diet on Metabolic Parameters in Patients with Type 2 Diabetes

Cited by 91 publications

References 96 publications

Application of n-of-1 clinical trials in personalized nutrition research: a trial protocol for Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)

Application of n-of-1 clinical trials in personalized nutrition research: a trial protocol for Westlake N-of-1 Trials for Macronutrient Intake (WE-MACNUTR)

Effect of Fiber-Rich Snacks on C-Reactive Protein and Atherogenic Index in Type 2 Diabetes Patients

Pengaruh yoghurt dan soyghurt kayu manis (Cinnamomum burmannii) terhadap kadar glukosa darah, insulin serum, dan malondialdehyde tikus pra sindrom metabolik

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