Control of antibiotic resistance in China must not be delayed: The current state of resistance and policy suggestions for the government, medical facilities, and patients

Tang, Qi; Song, Peipei; Li, Jiajia; Kong, Fanlei; Sun, Long; Xu, Lingzhong

doi:10.5582/bst.2016.01034

Cited by 44 publications

(22 citation statements)

References 19 publications

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“…As of 2013, the total antibiotics usage in China was approximately 162,200 tons, of which 84,100 tons were for animals (Tang et al 2016). The use of antibiotics in China accounts for about half of the world.…”

Section: Introductionmentioning

confidence: 99%

Serotype distribution, antimicrobial susceptibility, antimicrobial resistance genes and virulence genes of Salmonella isolated from a pig slaughterhouse in Yangzhou, China

Yin

Zheng

et al. 2019

AMB Expr

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Salmonella is an important food-borne pathogen associated with public health and high economic losses. To investigate the prevalence and the characteristics of Salmonella in a pig slaughterhouse in Yangzhou, a total of 80 Salmonella isolates were isolated from 459 (17.43%) samples in 2016-2017. S. Derby (35/80, 43.75%) was the most prevalent, followed by S. Rissen (16/80, 20.00%) and S. Newlands (11/80, 13.75%). The highest rates of susceptibility were observed to cefoxitin (80/80, 100.0%) and amikacin (80/80, 100.0%), followed by aztreonam (79/80, 98.75%) and nitrofurantoin (79/80, 98.75%). The highest resistance rate was detected for tetracycline (65/80, 81.25%), followed by ampicillin (60/80, 75.00%), bactrim (55/80, 68.75%), and sulfisoxazole (54/80, 67.50%). Overall, 91.25% (73/80) of the isolates were resistant to at least one antibiotic, while 71.25% (57/80) of the isolate strains were multidrug resistant in the antimicrobial susceptibility tested. In addition, 86.36% (19/22) of the 22 antimicrobial resistance genes in the isolates were identified. Our data indicated that the resistance to certain antimicrobials was significantly associated, in part, with antimicrobial resistance genes. Furthermore, 81.25% (65/80) isolates harbored the virulence gene of mogA, of which 2 Salmonella Typhimurium isolates carried the mogA, spvB and spvC virulence genes at the same time. The results showed that swine products in the slaughterhouse were contaminated with multidrug resistant Salmonella commonly, especially some isolates carry the spv virulence genes. The virulence genes might facilitate the dissemination of the resistance genes to consumers along the production chain, suggesting the importance of controlling Salmonella during slaughter for public health.

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Section: Introductionmentioning

confidence: 99%

Serotype distribution, antimicrobial susceptibility, antimicrobial resistance genes and virulence genes of Salmonella isolated from a pig slaughterhouse in Yangzhou, China

Yin

Zheng

et al. 2019

AMB Expr

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“…The seriousness of the problem of bacterial resistance is confirmed by the number of deaths associated with drugresistant bacterial infections (Chudobova et al, 2014). Currently, antibiotic resistance is rising to dangerously high levels in all parts of the world (Tang et al, 2016). Resistant microorganisms are able to withstand an attack of antimicrobial medicines, so that standard treatments become ineffective and infections persist increasing the risk of spreading to others (WHO, 2014).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility and presence of resistance & enterotoxins/enterotoxin-likes genes inStaphylococcus aureusfrom food

Zhao

Tang

et al. 2017

CyTA - Journal of Food

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The aim of this study was to investigate the antibiotic resistance profiles and staphylococcal enterotoxins/enterotoxin-likes genes (se/sel) of Staphylococcus aureus from food. About 93 S. aureus strains were screened and 43 strains harbored se/sel genes, which were from raw meat, pickles, cooked meat, egg products, bean products, aquatic products, grains and fresh vegetables, respectively. Among the 21 se/sel genes, selx gene was found in 30/93 (32.26%) strains, followed by seb, ser, sea, sec, selp, sell and set. About 50/93 strains carried 10 antibiotic resistance genes. The prevalence rate of norA, chlA and grlA genes was relatively high, followed by ermC, tetA, aac6ʹ/ aph2", ermB, tetM, msrA and blaZ. Sixty-two strains of the 93 S. aureus isolates (62/93, 66.67%) were multidrug-resistant (≥3 antimicrobial agents). Susceptibilidad antimicrobiana de Staphylococcus aureus aislada de alimentos, presencia de genes de resistencia, de genes de enterotoxinas y de genes parecidos a enterotoxinas RESUMEN El presente estudio se orientó a investigar los perfiles de resistencia a los antibióticos y los genes de enterotoxinas estafilocócicas y de aquellos parecidos a enterotoxinas (se/sel) de S. aureus aislada de alimentos. Con este objetivo se cribaron 93 cepas de S. aureus, 43 de las cuales albergaban genes se/ sel, procedentes de carne cruda, pepinillos, carne cocida, productos de huevo, productos de frijol, productos acuáticos, granos y verduras frescas. En 30 de las 93 cepas (32,26%) se encontró el gen selx entre los 21 genes se/sel y, en orden descendente, los genes seb, ser, sea, sec, selp, sell y set. Asimismo, se constató que 50 de las 93 cepas albergaban 10 genes de resistencia a los antibióticos. La tasa de prevalencia de los genes norA, chlA y grlA fue relativamente elevada siguiéndole, en orden descendente, las de los genes ermC, tetA, aac6ʹ/aph2", ermB, tetM, msrA y blaZ. De las 93 cepas de S. aureus aisladas (62/93, 66,67%) 62 son resistentes a diversos medicamentos (≥tres agentes antimicrobianos).

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“…P. aeruginosa and A. baumannii are very resistant bacteria, particularly causing infections in the intensive care units, and their antibiotic resistance tends to increase in recent years [8][9][10]. As the carbapenem group of antibiotics are the last available option, carbapenem resistance has a particular importance.…”

Section: Comparison Of Rt-pcr With Phenotypic Methods For Metallo-betmentioning

confidence: 99%

Evaluation of metallo-beta-lactamase production in multiple antibiotic-resistant Pseudomonas spp. and Acinetobacter baumannii strains

Güzel

Afsar²,

Akdoğan

et al. 2018

Biotechnology & Biotechnological Equipment

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This study aimed to evaluate the metallo-beta-lactamase (MBL) production in Pseudomonas spp. and Acinetobacter baumannii using phenotypic and genotypic methods and to determine the most appropriate phenotypic method. The study included 55 Pseudomonas spp. (53 Pseudomonas aeruginosa, 1 P. fluorescens and 1 P. putida) and 33 A. baumannii isolates which were resistant to imipenem (IMP) and/or meropenem (MEM). Six phenotypic and one genotypic (real-time polymerase chain reaction [RT-PCR]) methods were used. According to the phenotypic tests, the rates of MBL-positive Pseudomonas spp. and A. baumannii were, respectively: 25.5% and 39.4% by the gradient test; 21.8% and 21.2% by the Rosco rapid CARB screen test; 9.1% and 21.2% by the modified Hodge test (MHT); 32.7% and 66.7% by the combined EDTA disk diffusion test; 56.4% and 100% by IMP þ EDTA and 49.0% and 72.7% by MEM þ EDTA and 9.1% and 3.0% by IMP þ dipicolinic acid (DPA) for the Rosco MBL confirm test; 36.4% and 6.1% by IMP þ DPA and 54.5% and 6.1% MEM þ DPA for the double disk synergy test. MBL genes were detected only in three Pseudomonas spp. (bla IMP in two P. aeruginosa isolates and bla VIM in a P. fluorescens isolate). For Pseudomonas spp., the MBL positivity rate did not significantly differ between the RT-PCR and MHT and between the RT-PCR and Rosco MBL confirm test (with IMP þ DPA) (p > 0.10). In conclusion, the Rosco MBL confirm test (with IMP þ DPA) phenotypically predicted the MBL positivity most closely to the RT-PCR method for both Pseudomonas spp. and A. baumannii isolates. ARTICLE HISTORY

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Control of antibiotic resistance in China must not be delayed: The current state of resistance and policy suggestions for the government, medical facilities, and patients

Cited by 44 publications

References 19 publications

Serotype distribution, antimicrobial susceptibility, antimicrobial resistance genes and virulence genes of Salmonella isolated from a pig slaughterhouse in Yangzhou, China

Serotype distribution, antimicrobial susceptibility, antimicrobial resistance genes and virulence genes of Salmonella isolated from a pig slaughterhouse in Yangzhou, China

Antimicrobial susceptibility and presence of resistance & enterotoxins/enterotoxin-likes genes inStaphylococcus aureusfrom food

Evaluation of metallo-beta-lactamase production in multiple antibiotic-resistant Pseudomonas spp. and Acinetobacter baumannii strains

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