Control of Calcium Regulating Hormones in the Vertebrates: Parathyroid Hormone, Calcitonin, Prolactin, and Stanniocalcin

Bonga, S.E. Wendelaar; Pang, Peter K.T.

doi:10.1016/s0074-7696(08)60499-4

Cited by 150 publications

(65 citation statements)

References 269 publications

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“…These endocrine structures, whose main product is stanniocalcin, a hypokalemic hormone (Youson, 2007), is absent in some teleost species (Wendelaar Bonga and Pang, 1991).…”

Section: The Interrenal Gland and Its Contextmentioning

confidence: 99%

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

Morandini¹,

Honji²,

Ramallo³

et al. 2014

General and Comparative Endocrinology

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“…These endocrine structures, whose main product is stanniocalcin, a hypokalemic hormone (Youson, 2007), is absent in some teleost species (Wendelaar Bonga and Pang, 1991).…”

Section: The Interrenal Gland and Its Contextmentioning

confidence: 99%

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

Morandini¹,

Honji²,

Ramallo³

et al. 2014

General and Comparative Endocrinology

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“…In fishes administration of calcitonin (CT) produced conflicting results -no effect, hypocalcemia and hypercalcemia (Wendelaar Bonga & Pang 1991, Chakrabarti & Mukherjee 1993, Oughterson et al 1995, Srivastav et al 1998a,b, Mukherjee et al 2004). This conflict regarding the effect of CT in fishes has led some workers to suggest that CT is involved either with osmotic regulation (Yamauchi et al 1978), sex-related phenomenon (Yamane & Yamada 1977, Suzuki 2005, skeletal protection during periods of high calcium demands (Wendelaar Bonga & Pang 1991) and to protect scales from excess degradation of calcium at vitellogenesis (Suzuki et al 2000). CT has also been suggested to control dietary calcium uptake (Suzuki et al 1999) and inhibit calcium transport in fish gills (Wagner et al 1997, Mukherjee et al 2004.…”

Section: Introductionmentioning

confidence: 99%

Ultimobranchial gland of freshwater catfish, Heteropneustes fossilis, in response to calcitonin administration

et al. 2009

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The absence o!!f a hypocalcemic effect of calcitonin (CT) in fishes has been suggested due to exceedingly high plasma levels of CT; the fish may be saturated with respect of circulating CT and therefore unable to respond to exogenously administered CT. Earlier it has been suggested that a hypocalcemic action of injected CT may be obscured by changes in the release of endogenous CT and other calcium regulating hormones. In this study we have used artificial freshwater, calcium-deficient freshwater and calcium-rich freshwater and injected the fish with CT. The aim behind selecting these media were (i) in calcium-deficient medium there would be reduced circulating levels of CT, (ii) in calciumrich medium there would be diminished secretion of prolactin (this hormone is hypercalcemic in fish), and (iii) by keeping the fish in calcium-rich medium we can test the antihypercalcemic action of CT. Moreover, the present study would reveal the changes in the ultimobranchial gland (UBG) after keeping the fish in all the above three media and/or injecting the fish with CT. Freshwater catfish, Heteropneustes fossilis, were administered intraperitoneally daily with vehicle or 0.5 U/100g body wt of salmon calcitonin (CT) and kept in artificial freshwater, calcium-rich freshwater and calcium-deficient freshwater for 10 days. Blood samples were collected on 1, 3, 5, and 10 days following the treatment and analyzed for serum calcium levels. The ultimobranchial gland (UBG) was also fixed for histological studies on these intervals. In artificial freshwater there was no change in the serum calcium levels of calcitonin-injected fish. The ultimobranchial gland of calcitonin-injected fish exhibited a progressive decrease in the nuclear volume from day 5 onwards. On day 10 vacuolization in the gland was also noticed. In vehicle-injected fish (control) kept in calcium-rich freshwater hypercalcemia has been noticed which persists till the end of the experiment. In calcitonin-treated fish maintained in calcium-rich freshwater there is no change in serum calcium level as compared to vehicle-injected fish. In vehicleinjected fish the UBG depicts decreased staining response and increased nuclear volume at day 5. On day 10 the nuclear volume is further increased and few degenerating cells have been noticed. Calcitonin fails to induce any histological change in the UBG as compared to control. In vehicle-injected fish kept in calcium-deficient freshwater the serum calcium levels decrease from day 1 to day 3. The levels exhibit hypercalcemia on day 10. CT treatment to the fish kept in calcium-deficient freshwater evokes a decrease in the calcium levels on day 1 and day 3. A significant hypercalcemia has been noticed on day 5 and day 10. In vehicle-injected fish kept in calcium-deficient freshwater the UBG reveals a decreased staining response on day 10. In CT-injected fish maintained in calcium-deficient freshwater the UBG depicts an increased nuclear volume and few exhausted cells on day 10. It can be concluded that CT can provoke hypocalcemia o...

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“…The present observation that plasma calcium lev els were similar in freshwater and seawater eels, irrespective of the almost tenfold difference in water calcium concentration suggests that the ac tivity of the CS, the only endocrine gland producing a potent hypocalcemic hormone in eel (Wendelaar Bonga and Pang 1991), should be higher in sea water than in freshwater. The present kinetic data support this hypothesis.…”

Section: Discussionmentioning

confidence: 49%

“…Since the MCR of prolactin is higher in freshwater fish (Sakamoto et al 1991), we consider it unlikely that an overall non-specific activation of organs which help clear peptide hormones from the blood (liver, gut and kidney), explains the higher MCR of STC in seawater eels. STC expresses its function by controlling the transcellular calcium transport of the chloride cell, its principal target (Wendelaar Bonga and Pang 1991). The increased DS of STC in seawater eel could have resulted from an increase in the number of receptors consequent to the increase in number and volume of the chloride cells observed after transfer of freshwater adapted eel to seawater (Pisam et al 1987).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Stanniocalcin kinetics in freshwater and seawater european eel (Anguilla anguilla)

Hanssen

Mayer-Gostan²,

Flik

et al. 1993

Fish Physiol Biochem

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The kinetics and hypocalcemic potency of stanniocalcin (STC) were examined in freshwater and seawater eels. The secretion rate and the metabolic clearance rate of STC were calculated from the STC disappearance curve after intra-arterial injection of trout STC. Basal plasma STC concentrations in freshwater and seawater eels did not differ but the STC secretion rate and metabolic clearance rate in seawater eel were 7 0 -7 5 % higher than in FW eel. The increased STC distribution space in seawater eels suggests that the STC receptor density was increased. STC had a higher hypocalcemic potency in seawater than in freshwater eels. These observa tions support the hypothesis that seawater fish require more hormonal control over transcellular influx of calcium than freshwater fish.

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Control of Calcium Regulating Hormones in the Vertebrates: Parathyroid Hormone, Calcitonin, Prolactin, and Stanniocalcin

Cited by 150 publications

References 269 publications

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

The interrenal gland in males of the cichlid fish Cichlasoma dimerus: Relationship with stress and the establishment of social hierarchies

Ultimobranchial gland of freshwater catfish, Heteropneustes fossilis, in response to calcitonin administration

Stanniocalcin kinetics in freshwater and seawater european eel (Anguilla anguilla)

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