Control of connective tissue metabolism by lasers: Recent developments and future prospects

Abergel, R. Patrick; Meeker, C A; Lam, Thomas S.; Dwyer, Richard M.; Lesavoy, Malcolm A.; Uitto, Jouni

doi:10.1016/s0190-9622(84)80194-2

Cited by 231 publications

(89 citation statements)

References 12 publications

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“…Keloids treated with triamcinolone have decreased levels of the proteinase inhibitors alpha 2 -macroglobulin and alpha 1 -antitrypsin, suggesting that these collagenase inhibitors are removed by corticosteroids [7]. Other mechanisms such as decreased glucose-6-phosphate dehydrogenase activity, increased alanine transferase activity and decreased DNA content in keloid nodules have also been reported [10].…”

Section: Discussionmentioning

confidence: 98%

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Keloidoscope: in search for the ideal treatment of keloids

Anchlia

Rao

Bonanthaya

et al. 2009

J. Maxillofac. Oral Surg.

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Although keloids were recognised in the Smith Papyrus of ancient times, the precise definition, cause and management have remained elusive. Several forms of treatment have been used with varying success. Objectives This study assesses and compares the value of intralesional steroid (Triamcinolone acetonide 40mg/ml), cryotherapy and cryotherapy with intralesional steroid in the treatment of keloids. Methodology 33 patients were studied, 11 each in the three arms and the volume of the keloids was recorded using wax patterns of alginate impressions of the keloids to note the change in size postoperatively. Results The best average percentage response was observed is patients who received both Cryotherapy (CRY) and Intralesional Steroid (ILS) (69.02%) followed by patients who received only intralesional steroid (43.98%). Among the patients who received only cryotherapy, the average percentage response was only 39.24%. 72.73% patients who received intralesional steroid with cryotherapy showed more than 50% improvement (good response) while only 9.09% patients who received intralesional steroid alone and cryotherapy alone showed similar improvement. Conclusion In patients with keloids good response can be obtained with CRY with ILS as compared to ILS alone and CRY alone.

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Section: Discussionmentioning

confidence: 98%

“…Abergel et al [7] demonstrated a photobiological effect of laser light on collagen metabolism using Neodymium: Yttrium-Aluminium-Garnate (Nd:YAG) 1064nm continuous wave laser.…”

Section: Lasersmentioning

confidence: 99%

Keloidoscope: in search for the ideal treatment of keloids

Anchlia

Rao

Bonanthaya

et al. 2009

J. Maxillofac. Oral Surg.

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“…In this work, Hardy et al [29] reported a five-fold increase in the number of fibroblasts exposed to four 10.0 J cm -2 doses of pulsed ruby laser when compared to controls that were not treated with laser light. Subsequent studies have since shown that the increased proliferation of fibroblasts results in increased collagen synthesis in vitro as well as in vivo [30][31][32][33][34][35][36][37][38]. For example, a total of 4.0 joules laser energy applied on experimentallyinduced skin incisions [39] or skin defects in rats [30], produces faster collagen synthesis as judged by assaying 14 C glycine and 3H proline or 3H hydroxyproline [30,39].…”

Section: Effects Of Laser Photostimulationmentioning

confidence: 99%

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Enwemeka

Reddy

2000

LASER THERAPY

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Connective tissue injuries, such as tendon rupture and ligamentous strains, are common. Unlike most soft tissues that require 7-10 days to heal, primary healing of tendons and other dense connective tissues take as much as 6 -8 weeks during which they are inevitably protected in immobilization casts to avoid re-injury. Such long periods of immobilization impair functional rehabilitation and predispose a multitude of complications that could be minimized if healing is quickened and the duration of cast immobilization reduced. In separate studies, we tested the hypothesis that early function, ultrasound, 632.8 nm He-Ne laser, and 904 nm Ga-As laser, when used singly or in combination, promote healing of experimentally severed and repaired rabbit Achilles tendons as evidenced by biochemical, biomechanical, and morphological indices of healing. Our results demonstrate that: (1) appropriate doses of each modality, i.e., early functional activities, ultrasound, He-Ne and Ga-As laser therapy augment collagen synthesis, modulate maturation of newly synthesized collagen, and overall, enhance the biomechanical characteristics of the repaired tendons. (2) Combinations of either of the two lasers with early function and either ultrasound or electrical stimulation further promote collagen synthesis when compared to functional activities alone. However, the biomechanical effects measured in tendons receiving the multi-therapy were similar, i.e., not better than the earlier single modality trials. Although tissue repair processes in humans may differ from that of rabbits, these findings suggest that human cases of connective tissue injuries, e.g., Achilles tendon rupture, may benefit from appropriate doses of He-Ne laser, Ga-As laser, and other therapeutic modalities, when used singly or in combination. Our recent meta-analysis of the laser therapy literature further corroborate these findings.

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“…[6][7][8][9][10][11][12][13] Some lasers, when used with the proper parameters, affect fibroblasts and collagen production in vitro, and promising results have been found utilizing the HeNe laser (632.8 nm) with multiple exposures. 9,[14][15][16][17][18][19] One effect of laser therapy (5 J/cm 2 ) is increased local blood flow in normal human skin of the sole of the foot. 6 A comparative study of LLLT on fibroblasts in vitro, using fluence of 2 J/cm 2 and various irradiances, concluded that the proliferation rate of human gingival fibroblasts was increased when under conditions of nutritional deficit and stress.…”

Section: Introduction Dmentioning

confidence: 99%

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

Rabêlo

Villaverde

Nicolau

et al. 2006

Photomedicine and Laser Surgery

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Objective: The aim of this work was to compare the effect of low-level laser therapy (LLLT) on the wound healing process in nondiabetic and diabetic rats. Background Data: Among the clinical symptoms caused by diabetes mellitus, a delay in wound healing is a potential risk for patients. It is suggested that LLLT can improve wound healing. Methods: The tissue used for this study was extracted from animals suffering from diabetes, which was induced by Streptozotocin ® , and from nondiabetic rats. Animals were assembled into two groups of 25 rats each (treated and control) and further subdivided into two groups: diabetic (n = 15) and nondiabetic (n = 10). A full-thickness skin wound was made on the dorsum area, with a round 8-mm holepunch. The treated group was irradiated by a HeNe laser at 632.8 nm, with the following parameters: 15 mW, exposition time of 17 sec, 0.025 cm 2 irradiated area, and energy density of 10 J/cm 2 . Square full-thickness skin samples (18 mm each side, including both injured and noninjured tissues) were obtained at 4, 7, and 15 days after surgery and analyzed by qualitative and quantitative histological methods. Results: Quantitative histopathological analysis confirmed the results of the qualitative analysis through histological microscope slides. When comparing tissue components (inflammatory cells, vessels and fibroblast/area), we found that treated animals had a less intense inflammatory process than controls. Conclusion: Results obtained by both qualitative and quantitative analyses suggested that irradiation of rats with HeNe (632.8 nm), at the tested dose, promoted efficient wound healing in both nondiabetic and diabetic rats as, compared to the control group. 474

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Control of connective tissue metabolism by lasers: Recent developments and future prospects

Cited by 231 publications

References 12 publications

Keloidoscope: in search for the ideal treatment of keloids

Keloidoscope: in search for the ideal treatment of keloids

The Biological Effects of Laser Therapy and Other Physical Modalities on Connective Tissue Repair Processes

Comparison between Wound Healing in Induced Diabetic and Nondiabetic Rats after Low-Level Laser Therapy

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