Control of coughing by medullary raphé

Poliaček, Ivan; Jakus, J; Simera, Michal; Veternik, Marcel; Plevková, Jana

doi:10.1016/b978-0-444-63488-7.00014-8

Cited by 9 publications

(8 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the most rostral location affected expiratory drive and CN. This regionality confirms previous reports from several groups related to cough (Baekey et al 2003, Holtman et al 1986, Jakus et al 1998, Lalley 1986, Poliacek et al 2014; but also to breathing and other airway protective reflexes (Sessle et al 1981, Haxhiu et al 1998. Stimulation in NRM and the dorsal NRO reduced respiratory motor output, those in the NRP and ventral NRO stimulated breathing (Besnard et al 2009, Holtman et al 1986, Lalley 1986, Millhorn 1986, Aoki et al 1995.…”

Section: Discussionsupporting

confidence: 90%

“…The structures and coordinates are consistent with published data (Berman 1968) and our own adjustments (Poliacek et al 2017). Control aCSF microinjections (and related analysis of data) were performed during our previous experiments (Poliacek et al 2012(Poliacek et al , 2014. Medial plane reconstructions on the left, transversal planes on the right.…”

Section: Methodssupporting

confidence: 79%

See 1 more Smart Citation

Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Martvon¹,

Kotmanova²,

Dobrolubov³

et al. 2020

Physiol Res

View full text Add to dashboard Cite

We studied the effects of GABA receptor agonists microinjections in medullary raphé on the mechanically induced tracheobronchial cough response in anesthetized, unparalyzed, spontaneously breathing cats. The results suggest that GABA-ergic inhibition significantly contributes to the regulation of cough reflex by action of both GABAA and GABAB receptors. The data are consistent with inhomogeneous occurrence of GABA-ergic neurons in medullary raphé and their different involvement in the cough reflex control. Cells within rostral nucleus raphé obscurus with dominant role of GABAA receptors and neurons of rostral nucleus raphé pallidus and caudal nucleus raphé magnus with dominant role of GABAB receptors participate in regulation of cough expiratory efforts. These cough control elements are distinct from cough gating mechanism. GABA-ergic inhibition in the raphé caudal to obex had insignificant effect on cough. Contradictory findings for GABA, muscimol and baclofen administration in medullary raphé suggest involvement of coordinated activity of GABA on multiple receptors affecting raphé neurons and/or the local neuronal circuits in the raphé modulating cough motor drive.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Methodssupporting

confidence: 79%

Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Martvon¹,

Kotmanova²,

Dobrolubov³

et al. 2020

Physiol Res

View full text Add to dashboard Cite

show abstract

“…However, on the basis of brainstem transection experiments, they concluded that RTN/pFRG neurons may modulate expiratory activity during normal eucapnic breathing, but are not essential elements of the neural network responsible for coughing and swallowing. Recording experiments have been confirmed by studies on the expression of the immediate early gene c-fos during coughing (Gestreau et al, 1997;Jakus et al, 2008) as well as by lesion experiments (Jakuš et al, 1998(Jakuš et al, , 2000Mutolo et al, 2002;Poliacek et al, 2004Poliacek et al, , 2005Poliacek et al, , 2014; Simera et al, 2013 also for further Refs.). It has been shown that several brainstem regions either with or without respiration-related neuronal activities may have a role in the production of the cough motor pattern.…”

Section: Neuronal Recordings C-fos Immunohistochemistry and Lesion Ementioning

confidence: 53%

Brainstem mechanisms underlying the cough reflex and its regulation

Mutolo

2017

Respiratory Physiology & Neurobiology

View full text Add to dashboard Cite

A B S T R A C TCough is a very important airway protective reflex. Cough-related inputs are conveyed to the caudal nucleus tractus solitarii (cNTS) that projects to the brainstem respiratory network. The latter is reconfigured to generate the cough motor pattern. A high degree of modulation is exerted on second-order neurons and the brainstem respiratory network by sensory inputs and higher brain areas. Two medullary structures proved to have key functions in cough production and to be strategic sites of action for centrally active drugs: the cNTS and the caudal ventral respiratory group (cVRG). Drugs microinjected into these medullary structures caused downregulation or upregulation of the cough reflex. The results suggest that inhibition and disinhibition are prominent regulatory mechanisms of this reflex and that both the cNTS and the cVRG are essential in the generation of the entire cough motor pattern. Studies on the basic neural mechanisms subserving the cough reflex may provide hints for novel therapeutic approaches. Different proposals for further investigations are advanced.

show abstract

“…Thus, there is a high probability that the execution of one motor behavior (e.g. swallow) directly shares excitability with elements of cough network [22,23]. …”

Section: Discussionmentioning

confidence: 99%

Cough Modulation by Upper Airway Stimuli in Cat—Potential Clinical Application?

Poliaček

Plevková

Pitts

et al. 2016

OJMIP

Self Cite

View full text Add to dashboard Cite

The modulation of mechanically induced tracheobronchial cough was tested by applying various stimuli and the elicitation of other airway protective behaviors in pentobarbital anesthetized cats. Capsaicin and histamine were injected in the nose, and mechanical nylon fiber and / or air puff stimulation was applied to the nose and nasopharynx. Reflex responses of cough, sneeze, aspiration reflex and expiration reflex were induced mechanically. Swallow was initiated by the injection of water into oropharynx. Subthreshold mechanical stimulation of nasopharyngeal and nasal mucosa, as well as water stimulation in the oropharynx and larynx, with no motor response, had no effect on rhythmic coughing. Cough responsiveness and excitability increased with capsaicin and air puff stimuli delivered to the nose. Vice versa, the number of cough responses was reduced and cough latency increased when aspiration reflexes (>1) occurred before the cough stimulus or within inter-cough intervals (passive E2 cough phase). The occurrence of swallows increased the cough latency as well. Cough inspiratory and / or expiratory motor drive was enhanced by the occurrence of expiration reflexes, swallows, and sneezes and also by aspiration reflex within the inspiratory phase of cough and by nasal air puff stimuli. Complex central interactions, ordering and sequencing of motor acts from the airways may result in the disruption of cough rhythmic sequence but also in the enhancement of cough. Our data confirm that number of peripheral stimuli and respiratory motor responses significantly alters cough performance. We propose developing and testing stimulation paradigms that modify coughing and could be employed in correcting of inappropriate or excessive coughing.

show abstract

Control of coughing by medullary raphé

Cited by 9 publications

References 86 publications

Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Brainstem mechanisms underlying the cough reflex and its regulation

Cough Modulation by Upper Airway Stimuli in Cat—Potential Clinical Application?

Contact Info

Product

Resources

About