Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Martvon, Lukas; Kotmanova, Zuzana; Dobrolubov, Boris; Babalova, Lucia; Simera, Michal; Veternik, Marcel; Pitts, Teresa; Jakus, J; Poliaček, Ivan

doi:10.33549/physiolres.934401

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…It is also a positive regulator of the secretion of GABA, an inhibitory neurotransmitter with anti-inflammatory activity 32 . Animal models 51,52 and controlled trials 53,54 have demonstrated that agonists to GABA receptors inhibit the cough reflex; specifically, baclofen has been shown to supress ACEI-induced cough 55 . Further, INHBC is expressed in the nervous system and is known to suppress inflammatory pain responses 42 and current evidence demonstrates the role of BTBD11 in regulating glutamatergic synapse function 43 .…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study of ACE inhibitor-induced cough implicates neuropeptides and shows genetic overlap with chronic dry cough

Coley

Shepherd

Packer

et al. 2022

Preprint

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ACE inhibitors (ACEIs) are commonly prescribed for hypertension, a global risk factor for cardiovascular disease. Their primary side effect is a dry cough which affects 5-35% of users. As clinical guidelines recommend switching those experiencing cough to an angiotensin-II receptor blocker, we have used this switch as a proxy for ACEI-induced cough. Through a two-stage multi-ancestry genome-wide association study, including up to 7,030 cases and 39,921 controls, we identify five independent genome-wide significant associations implicating six protein-coding genes, including INHBC, KCNIP4, NTSR1 and PREP which encode proteins involved in the nervous system. We also observe genetic overlap between ACEI-induced cough and chronic dry cough through genetic correlation and phenome-wide association studies. In line with existing hypotheses, our findings suggest a neurological basis for the pathology of ACEI-induced cough, particularly the role of proinflammatory mediators in sensory airway sensitivity and cough reflex modulation, and shared biological mechanisms with chronic dry cough.

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Section: Discussionmentioning

confidence: 99%

Genome-wide association study of ACE inhibitor-induced cough implicates neuropeptides and shows genetic overlap with chronic dry cough

Coley

Shepherd

Packer

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

GABAB Receptor Chemistry and Pharmacology: Agonists, Antagonists, and Allosteric Modulators

Nieto

Bailey

Kaczanowska

et al. 2021

Current Topics in Behavioral Neurosciences

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Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

Poliacek,

Veterník,

Martvon

et al. 2025

Journal of Applied Physiology

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The influence of peripheral antitussive drugs on spatiotemporal features of coughing have not been reported. We hypothesized that this class of compounds would alter the cough motor pattern, in part, by lengthening cough phases. Peripherally acting antitussives 3-Aminopropylphosphinic Acid (3APPi, 5mg/kg) and levodropropizine (Levo, 3mg/kg) were injected i.v. in anesthetized spontaneously breathing cats (13 males, 2 females; 4.38 ± 0.19 kg). Spatio-temporal analysis of cough induced by mechanical stimulation of the trachea showed significant reductions in cough number and expiratory cough efforts after administration of each drug. A significant reduction in inspiratory cough efforts occurred after Levo. Both drugs induced temporal changes in the cough motor pattern, including prolongations of inspiratory phase, inspiratory-expiratory transition, total cough diaphragm activity and total cough cycle duration. Levo also significantly lengthened the expiratory phase of cough. A shortening of the overlap between diaphragm and abdominal activity and cough abdominal EMG activity was observed after the administration of 3APPi. No significant changes in cardiorespiratory data were seen, with the exception of prolonged expiratory phase after 3APPi and lower blood pressure after Levo. Peripherally induced cough suppression is accompanied with changes in cough temporal characteristics that are not observed after administration of centrally acting antitussives. The motor output produced by the cough central pattern generator differs significantly when coughing is perturbed by peripherally and centrally acting antitussives.

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Modulation of Cough Reflex by Gaba-Ergic Inhibition in Medullary Raphé of the Cat

Cited by 4 publications

References 35 publications

Genome-wide association study of ACE inhibitor-induced cough implicates neuropeptides and shows genetic overlap with chronic dry cough

Genome-wide association study of ACE inhibitor-induced cough implicates neuropeptides and shows genetic overlap with chronic dry cough

GABAB Receptor Chemistry and Pharmacology: Agonists, Antagonists, and Allosteric Modulators

Peripheral antitussives affect temporal features of tracheobronchial coughing in cats

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