Control of Dopamine Release in the Retina: a Transgenic Approach to Neural Networks

Gustincich, Stefano; Feigenspan, Andreas; Wu, Doris K.; Koopman, Laura J; Raviola, Elio

doi:10.1016/s0896-6273(00)80313-x

Cited by 198 publications

(273 citation statements)

References 51 publications

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“…Furthermore, the existence of distinct high-and low-bursting populations of DA cells, which are uniformly converted to high bursting through synaptic blockade, suggests heterogeneity in the degree of synaptic regulation of intrinsic bursting activity across DA cells. Thus, our results do not support the previous proposal that disinhibition of OFF-driven GABAergic amacrine input is a principal mechanism of DA cell light responses (Critz and Marc, 1992;Gustincich et al, 1997). The predominance of physiologically defined ON pathway input and apparent lack of OFF pathway input to DA cells is surprising, given the ramification of DA cell processes in the outer portion of the retinal inner plexiform layer (IPL) where OFF synapses are made.…”

Section: Da Cell Spontaneous Activity and Regulationcontrasting

confidence: 99%

“…DA cells are postsynaptic to glutamatergic bipolar cells, GABAergic amacrine cells, and glycinergic AII amacrine cells and express a variety of ionotropic glutamate, GABA A , and glycine receptors (Gustincich et al, 1997(Gustincich et al, , 1999). Thus, we tested the ability of each of these synaptic inputs to regulate DA cell firing by applying specific receptor blockers in the dark (Table 2).…”

Section: Synaptic Inputs Inhibit Da Cell Burstingmentioning

confidence: 99%

“…One is by direct innervation of DA cells by ON bipolar cells (Hokoc and Mariani, 1987;Boelen et al, 1998), and a second is an indirect pathway through the disinhibition of a serial inhibitory network of GABAergic and/or glycinergic amacrine cells presynaptic to DA cells (Critz and Marc, 1992;Gustincich et al, 1997). To differentiate these possibilities, we recorded light responses of DA cells in the presence of either GABAzine or strychnine and found that robust ON light responses persisted under the blockade of GABA A or glycinergic neurotransmission (Fig.…”

Section: Transient and Sustained Da Cells Have Distinct Synaptic Inputsmentioning

confidence: 99%

See 2 more Smart Citations

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Zhang¹,

Zhou²,

McMahon³

2007

J. Neurosci.

114

149

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Section: Da Cell Spontaneous Activity and Regulationcontrasting

confidence: 99%

Section: Synaptic Inputs Inhibit Da Cell Burstingmentioning

confidence: 99%

Section: Transient and Sustained Da Cells Have Distinct Synaptic Inputsmentioning

confidence: 99%

See 1 more Smart Citation

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Zhang¹,

Zhou²,

McMahon³

2007

J. Neurosci.

114

149

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“…In mice, this promoter is expressed in a tissue-specific manner (Banerjee et al, 1992(Banerjee et al, , 1994. In transgenic mice, however, this promoter drove gene expressions in both type 1 (colocalization with TH antibodies) and type 2 (no colocalization with TH antibodies) catecholaminergic cells (Gustincich et al, 1997;Zhang et al, 2004). We demon-strate that this same TH promoter can be expressed in teleost.…”

Section: Discussionmentioning

confidence: 67%

Transgenic zebrafish that express tyrosine hydroxylase promoter in inner retinal cells

Gao

2005

Developmental Dynamics

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We have generated a transgenic zebrafish line [Tg(Th:GFP)] that expresses green fluorescence proteins (GFP) driven by rat tyrosine hydroxylase (TH) promoter. In zebrafish, the transgene was expressed as early as 16 hr postfertilization (hpf). The first transgene expression was detected in the midbrain. Within a few hours of development, the expression spread to the forebrain and hindbrain. In the retina, the first transgene expression was detected at approximately 40 hpf, at which time a single GFP-positive cell was seen in the ventral-nasal patch of the retina. In late development, GFP spread across the inner retina. GFP was found in retinal cells that expressed TH or phenylethanolamine N-methyl-transferase (PNMT), the first and last enzymes for synthesis of catecholamine, respectively. This suggests that the transgene is expressed in catecholaminergic neurons. Of interest, GFP was also detected in some retinal cells that release ␥-aminobutyric acid. These latter data suggest that the transgene may also be expressed in noncatecholaminergic cells. Developmental Dynamics 233:921-929, 2005.

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“…• p Ͻ 0.05; excitation received from ON-bipolar cells (Gustincich et al, 1997). The present results suggest that not only is the release of dopamine a subject of light-dark adaptation but also the dopaminergic receptor-expressing glutamatergic cells, responding in light with glutamate release after dopamine exposure, do not respond to dopaminergic stimulation in the dark.…”

Section: Mechanism Of Glial Cell Morphological Alterationsmentioning

confidence: 59%

Glutamate-Evoked Alterations of Glial and Neuronal Cell Morphology in the Guinea Pig Retina

Uckermann¹,

Vargová²,

Ulbricht³

et al. 2004

J. Neurosci.

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Neuronal activity is accompanied by transmembranous ion fluxes that cause cell volume changes. In whole mounts of the guinea pig retina, application of glutamate resulted in fast swelling of neuronal cell bodies in the ganglion cell layer (GCL) and the inner nuclear layer (INL) (by ϳ40%) and a concomitant decrease of the thickness of glial cell processes in the inner plexiform layer (IPL) (by ϳ40%) that was accompanied by an elongation of the glial cells, by a thickening of the whole retinal tissue, and by a shrinkage of the extracellular space (by ϳ18%). The half-maximal effect of glutamate was observed at ϳ250 M, after ϳ4 min. The swelling was caused predominantly by AMPAkainate receptor-mediated influx of Na ϩ into retinal neurons. Similar but transient morphological alterations were induced by high K ϩ and dopamine, which caused release of endogenous glutamate and subsequent activation of AMPA-kainate receptors. Apparently, retinal glutamatergic transmission is accompanied by neuronal cell swelling that causes compensatory morphological alterations of glial cells. The effect of dopamine was elicitable only during light adaptation but not in the dark, and glutamate and high K ϩ induced stronger effects in the dark than in the light. This suggests that not only the endogenous release of dopamine but also the responsiveness of glutamatergic neurons to dopamine is regulated by light-dark adaptation. Similar morphological alterations (neuronal swelling and decreased glial process thickness) were observed in whole mounts isolated immediately after experimental retinal ischemia, suggesting an involvement of AMPA-kainate receptor activation in putative neurotoxic cell swelling in the postischemic retina.Key words: glutamate; dopamine; ATP; neuroglia; circadian phase; ischemia; retina IntroductionGlial cells play crucial roles in supporting neuronal survival and information processing (Newman and Reichenbach, 1996): they regulate the extracellular homeostasis of relevant ions including K ϩ , control the water content of the extracellular space, and mediate the rapid termination of neuronal activity by transmitter uptake from the synaptic cleft (Matsui et al., 1999). In the retina, neuronally released K ϩ , water, and glutamate are cleared from the extracellular space mainly by the radial glial (Müller) cells. Retinal glial cells display a complex pattern of K ϩ channel expression in their plasma membranes that directs the flow of neuronally released K ϩ into the glial cell bodies and farther into the vitreous and the blood vessels (Kofuji et al., 2002). Parallel water fluxes were suggested to be coupled to the transglial K ϩ fluxes (Nagelhus et al., 1999). The K ϩ and water fluxes, generated by neuronal activity and mediated by glial cells, are accompanied by swelling of cells and shrinkage of the extracellular space caused by the decreased extracellular osmolality (Dietzel et al., 1980;Jendelová and Syková, 1991;Syková, 1991). Cell volume alterations are important, particularly under pathological conditions such as ...

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Control of Dopamine Release in the Retina: a Transgenic Approach to Neural Networks

Cited by 198 publications

References 51 publications

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Functional Heterogeneity of Retinal Dopaminergic Neurons Underlying Their Multiple Roles in Vision

Transgenic zebrafish that express tyrosine hydroxylase promoter in inner retinal cells

Glutamate-Evoked Alterations of Glial and Neuronal Cell Morphology in the Guinea Pig Retina

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