Control of fibrinolytic drug injection via real-time ultrasonic monitoring of blood coagulation

Abstract

In the present study, we investigated the capabilities of a novel ultrasonic approach for real-time control of fibrinolysis under flow conditions. Ultrasonic monitoring was performed in a specially designed experimental in vitro system. Fibrinolytic agents were automatically injected at ultrasonically determined stages of the blood clotting. The following clots dissolution in the system was investigated by means of ultrasonic monitoring. It was shown, that clots resistance to fibrinolysis significantly increases during the first 5 minutes since the formation of primary micro-clots. The efficiency of clot lysis strongly depends on the concentration of the fibrinolytic agent as well as the delay of its injection moment. The ultrasonic method was able to detect the coagulation at early stages, when timely pharmacological intervention can still prevent the formation of macroscopic clots in the experimental system. This result serves as evidence that ultrasonic methods may provide new opportunities for real-time monitoring and the early pharmacological correction of thrombotic complications in clinical practice.

Patient specific approach to analysis of shear-induced platelet activation in haemodialysis arteriovenous fistula

“…Acoustic diagnostic methods are of great interest to reduce the level of thrombotic complications in haemodialysis patients. To date, ultrasound methods have been applied not only for the acquisition of information on biomechanical AVF features (vessel geometry and flow waveforms) [ 44 ] but also for the direct detection of the initiation of thrombus formation [ 90 ]. Estimation of the SIPAct level in combination with the abovementioned methods may reduce the level of life-threatening complications in haemodialysis patients via timely antithrombotic intervention.…”

Uji Aktivitas Fibrinolitik Jus Cacing Tanah (Lumbricus rubellus) Pada Tikus yang Diberi Asam Traneksamat

“…Namun, penggunaan heparin dalam jangka waktu lama dapat menyebabkan efek samping perdarahan, trombositopenia, perubahan metabolisme lipid dan osteoporosis (Alban, 2012). Obat trombolitik seperti streptokinase, tissue plasminogen activator (tPA), dan urokinase (Ivlev et al, 2019) juga sangat mahal dan menimbulkan efek samping alergi, lisis sistemik dan perdarahan (Dubey et al, 2011;Uesugi et al, 2010). Antiplatelet seperti aspirin dan clopidogrel (Hogg & Weitz, 2017) masih menjadi perdebatan karena aspirin dilaporkan dapat menyebabkan perdarahan mayor, kekambuhan sakit vaskular, dan di beberapa kasus terjadi resistensi aspirin.…”

Neonatal thrombosis: causes, pathogenesis, treatment features

“…Сделан вывод, что ультразвук помогает в регистрации той стадии тромбообразования, на которой тромболитическая терапия наиболее эффективна. Это позволяет предложить, что после неоднократных экспериментов и исследований будет разработана комплексная терапия неонатальных тромбозов [59].…”