Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal

Xu, Dan; Yu, Baoping; Luo, Hao; Chen, Lingdan

doi:10.3748/wjg.14.2882

Cited by 35 publications

(27 citation statements)

References 28 publications

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“…Xu et al . demonstrated that the cholecystokinin‐A receptor on TCs was essential for gallbladder muscle contractions in guinea pig muscle strips. Sun et al .…”

Section: Discussionmentioning

confidence: 98%

Telocytes: new insight into the pathogenesis of gallstone disease

Matyja

Gil

Pasternak

et al. 2013

J Cellular Molecular Medi

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The major mechanisms of gallstone formation include biliary cholesterol hypersecretion, supersaturation and crystallization, mucus hypersecretion, gel formation and bile stasis. Gallbladder hypomotility seems to be a key event that triggers the precipitation of cholesterol microcrystals from supersaturated lithogenic bile. Telocytes, a new type of interstitial cells, have been recently identified in many organs, including gallbladder. Considering telocyte functions, it is presumed that these cells might be involved in the signalling processes. The purpose of this study was to correlate the quantity of telocytes in the gallbladder with the lithogenicity of bile. Gallbladder specimens were collected from 24 patients who underwent elective laparoscopic cholecystectomy for symptomatic gallstone disease. The control group consisted of 25 consecutive patients who received elective treatment for pancreatic head tumours. Telocytes were visualized in paraffin sections of gallbladders with double immunofluorescence using primary antibodies against c-Kit (anti-CD117) and anti-mast cell tryptase. Cholesterol, phospholipid and bile acid levels were measured in gallbladder bile. The number of telocytes in the gallbladder wall was significantly lower in the study group than that in the control group (3.03 ± 1.43 versus 6.34 ± 1.66 cell/field of view in the muscularis propria, P < 0.001) and correlated with a significant increase in the cholesterol saturation index. The glycocholic and taurocholic acid levels were significantly elevated in the control subjects compared with the study group. The results suggest that bile composition may play an important role in the reduction in telocytes density in the gallbladder.

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“…Xu et al . demonstrated that the cholecystokinin‐A receptor on TCs was essential for gallbladder muscle contractions in guinea pig muscle strips. Sun et al .…”

Section: Discussionmentioning

confidence: 98%

Telocytes: new insight into the pathogenesis of gallstone disease

Matyja

Gil

Pasternak

et al. 2013

J Cellular Molecular Medi

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“…Rats were purchased from the Experiment Animal Center of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. They were housed under normal laboratory conditions (12/12-hour light-dark cycle, 18 C-22 C) and were given water ad libitum. The study was started after 1 week, when the rats were adapted to the environment.…”

Section: Materials and Methods Animalsmentioning

confidence: 99%

Electroacupuncture at Zusanli (ST-36) Restores Impaired Interstitial Cells of Cajal and Regulates Stem Cell Factor Pathway in the Colon of Diabetic Rats

Chen

Liu

et al. 2012

J Evid Based Complementary Altern Med

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The present study determined the effects of electroacupuncture on interstitial cells of Cajal and investigated whether changes in the stem cell factor pathway were involved. Animals were assigned to normal, diabetic, diabetic plus sham stimulation, diabetic plus low-frequency stimulation, and diabetic plus high-frequency stimulation groups. Electroacupuncture was performed daily for 8 weeks. In vitro contractility of colonic muscle strips were studied. Expression of c-kit (the marker of interstitial cells of Cajal) and stem cell factor were measured. The results showed that (1) contraction of colonic muscle strips was significantly elevated in low- and high-frequency stimulation groups and (2) in contrast to the diabetic group, the expressions of c-kit and stem cell factor were markedly increased in the low- and high-frequency stimulation groups. These results indicate that both low- and high-frequency stimulation can promote the contractility of colonic muscle strips partially through increasing the number of interstitial cells of Cajal, and these effects could be mediated by an elevated endogenous stem cell factor.

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“…ICLCs are believed to act as sources of spontaneous, electric slow waves responsible for paced contractions of GBSM, thus regulating the rhythm of gallbladder bile release. 27,28,30 A significantly smaller number of ICLCs was found in gallbladders from patients with cholelithiasis compared with those without gallstones. 31 Furthermore, a negative correlation between the number of ICLCs and bile CSI was discovered.…”

Section: Gallbladder Motilitymentioning

confidence: 98%

Cholesterol gallstone disease: focusing on the role of gallbladder

Chen

Kong

2015

Laboratory Investigation

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Gallstone disease (GSD) is one of the most common biliary tract diseases worldwide in which both genetic and environmental factors have roles in its pathogenesis. Biliary cholesterol supersaturation from metabolic defects in the liver is traditionally seen as the main pathogenic factor. Recently, there have been renewed investigative interests in the downstream events that occur in gallbladder lithogenesis. This article focuses on the role of the gallbladder in the pathogenesis of cholesterol GSD (CGD). Various conditions affecting the crystallization process are discussed, such as gallbladder motility, concentrating function, lipid transport, and an imbalance between pro-nucleating and nucleation inhibiting proteins.

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Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal

Cited by 35 publications

References 28 publications

Telocytes: new insight into the pathogenesis of gallstone disease

Telocytes: new insight into the pathogenesis of gallstone disease

Electroacupuncture at Zusanli (ST-36) Restores Impaired Interstitial Cells of Cajal and Regulates Stem Cell Factor Pathway in the Colon of Diabetic Rats

Cholesterol gallstone disease: focusing on the role of gallbladder

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