Control of Gastric Emptying by Osmolality of Duodenal Contents in Man

Meeroff, J. C.; Go, Vay Liang W.; Phillips, Sidney F.

doi:10.1016/s0016-5085(75)80228-9

Cited by 149 publications

(44 citation statements)

References 9 publications

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“…The measurement of intraluminal flow rates by dilution of a duodenal marker implies steady-state conditions and a constant gastric emptying rate. Such conditions are unlikely to exist during the first few hours after food intake resulting in an error of approximately 15% in the calculated duodenal flow rate over the whole period of meal evacuation (MacGregor et al, 1977;Malagelada et al, 1979;Meerof et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…Data analysis was based on the theory developed to investigate gastric emptying of liquid and solid-liquid meals in man (Malagelada et al, 1976;Meerof et al, 1975).…”

Section: Data Treatmentmentioning

confidence: 99%

“…We approached this problem by applying to drugs a technique previously described for investigating digestive physiology after ingestion of meals (Bernier & Lebert, 1971; Malagelada et al, 1976;Meerof et al, 1975). It is based on the following principle: after intubation of the stomach and intestine, gastric and duodenojejunal functions are evaluated by measuring the dilution of two aqueous non-absorbable markers, one present in a meal and the other simultaneously perfused into the duodenum.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Jobin¹,

Cortot²,

Godbillon³

et al. 1985

Brit J Clinical Pharma

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Gastrointestinal (GI) absorption of the beta‐adrenoceptor blocker metoprolol was investigated in five healthy subjects by means of an intubation method, employing a triple‐lumen tube introduced into the intestine, and a twin‐lumen tube in the stomach. Metoprolol was introduced into the stomach with a homogenized meal containing a nonabsorbable marker, [14C]‐PEG 4000, and another marker, PEG 4000, was perfused continuously into the duodenum just below the pylorus. Samples of GI contents were collected at regular intervals over 4 h in the stomach and at two different levels in the upper small intestine. Metoprolol was not absorbed from the stomach. Approximately 60% of the amount of drug emptied from the stomach was absorbed from the duodenum; about 50% of that leaving the duodenum was absorbed from the first part of the jejunum. The delivery process was the rate‐limiting factor of metoprolol absorption in these segments of the gut. Plasma concentrations reflected drug loss from the lumen and were higher in subjects exhibiting faster gastric emptying and higher absorption rates in the duodenum and jejunum. The intubation technique appeared to be a suitable method for investigating drug absorption from the GI tract in man.

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Section: Discussionmentioning

confidence: 99%

“…Data analysis was based on the theory developed to investigate gastric emptying of liquid and solid-liquid meals in man (Malagelada et al, 1976;Meerof et al, 1975).…”

Section: Data Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Jobin¹,

Cortot²,

Godbillon³

et al. 1985

Brit J Clinical Pharma

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“…Very acid conditions in the duodenum completely inhibit emptying and gastric electromyograms except after a very large meal when inhibition is incomplete (9,10,11). In man gastric emptying is fastest with isotonic solutions (118), and it has been suggested that the products of digestion of isoenergetic amounts of carbohydrate, fat, and protein have equal effects in the duodenum in slowing the rate of gastric emptying (17,59). In spite of small differences between diets in the rate of flow of liquid from the abomasum, the rate of flow of nutrients, e.g., protein and lipids, differs markedly between diets, especially if they do not coagulate in the abomasum (15,177).…”

Section: Nutritional Environmentmentioning

confidence: 99%

Factors Affecting Susceptibility of Calves to Disease

Roy¹

1980

Journal of Dairy Science

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Enteric and respiratory disorders are the main hazards to successful calf rearing. The many interrelated factors in the etiology of these disorders are reviewed, and an attempt has been to classify the factors into those of a microbiological, immunological, nutritional, genetic, physical, or psychological nature. No one would dispute that enteric and respiratory disorders are the two main hazards to calf health, but many would argue about the relative importance of specific pathogens and other predisposing factors in the etiology of these disorders.

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“…The observation that mechanoreceptors in the muscularis externa were sensitized by glucose-containing solutions makes it necessary to eliminate them rigorously when investigating putative specific chemoreceptors responding to glucose. From other reports of experiments using reflex techniques it is proposed that chemoreceptors responding to titratable acid may be located within 5 cm of the stomach in the dog (Cooke, 1974); that fat receptors may not be present in the first 5 cm in the dog duodenum (Cooke & Clarke, 1976); that osmoreceptors are not present in the first 5 cm of the dog duodenum (Cooke & Clarke, 1976) but may be present in the second to fourth part of the duodenum in man (Meeroff, Liang & Phillips, 1975) and that the duodenum of the calf may be sensitive to chemical solutions throughout its length (Bell & Holbrooke, 1979). The proximal segment in the rabbit was inaccessible to sensory recording using the technique reported here.…”

Section: Discussionmentioning

confidence: 99%

Mechanoreceptors of the Rabbit Duodenum

Cottrell¹

1984

Exp Physiol

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SUMMARYA preparation is described which allowed the investigation of single-unit afferent activity in non-myelinated mesenteric nerves in urethane-anaesthetized rabbits. Three classes of mechanoreceptors were isolated and were located in the muscularis externa (n = 17), the serosa (n = 5) and the mesentery (n = 2). Intraluminal perfusion of chemical solutions containing glucose and hypertonic saline caused increased movement in the loop and also excited mechanoreceptors. No specific chemoreceptors were identified. The results demonstrate that duodenal mechanoreceptors with non-myelinated axons in the rabbit are indirectly sensitive to the chemical composition of duodenal chyme.

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Control of Gastric Emptying by Osmolality of Duodenal Contents in Man

Cited by 149 publications

References 9 publications

Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.

Factors Affecting Susceptibility of Calves to Disease

Mechanoreceptors of the Rabbit Duodenum

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