Control of HIV-1 Replication by CD8 ⁺ T Cells Specific for Two Novel Pol Protective Epitopes in HIV-1 Subtype A/E Infection

Abstract

It is expected that HIV-1-specific CD8 + T cells that effectively suppress HIV-1 replication will contribute to HIV-1 vaccine development and therapy to achieve an HIV cure. T cells specific for protective epitopes were identified in HIV-1 subtype B and C infections but not in subtype A/E infection, which is epidemic in Southeast Asia.