Control of hydroxyapatite nanoparticle morphology using wet synthesis techniques: Reactant addition rate effects

Kramer, Erica; Podurgiel, Joseph; Wei, Mei

doi:10.1016/j.matlet.2014.05.105

Cited by 30 publications

(15 citation statements)

References 8 publications

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“…The crystallite domain is estimated as 13.8 nm (sample A), and 15.1 nm (after calcination, sample B), while the crystallinity degree is 21.3% (A), respectively 23.1% (B), so here both causes apply. For a fast mixing of reactants, as in our experiments, the decreased HAP crystallinity was also observed [9], as an outcome of the supersaturation and local inhomogeneity resulted from the rapid mixing of the phosphate and the calcium containing solutions. Calcination brings about a slight increase, both in crystallite size and crystallinity degree, as found also for related situations [10].…”

Section: Resultssupporting

confidence: 79%

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Mocanu¹,

Balint²,

Garbo³

et al. 2017

Studia UBB Chemia

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ABSTRACT. In order to obtain a low crystalline nanohydrxyapatite (HAP), suitable for biomedical application, a new synthesis procedure was developed, based on the aqueous precipitation method, at room temperature, without any additives. Accordingly, lyophilized HAP powders, both calcined and non calcined, were prepared, and characterized by XRD, TEM and AFM imaging, FTIR spectroscopy, zeta potential and BET measurements. The results confirmed HAP as the only phase present. The high porosity of this nanomaterial is attained. The nanoparticle size and shape as well as the crystallinity degree of the obtained HAP samples were also determined.

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Section: Resultssupporting

confidence: 79%

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Mocanu¹,

Balint²,

Garbo³

et al. 2017

Studia UBB Chemia

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“…The experimental involve additional of desired amount of 0.67 M of ortho-phosphoric acid (Merck, 85%) to desired amount of 1 M calcium hydroxide (Merck). The chemical equation involve is: 10Ca(OH) 2 + 6H 3 PO 4 Ca 10 (PO 4 ) 6 …”

Section: Materials and Methods Precipitationmentioning

confidence: 99%

“…There is a need to characterize the HA powder depending on desired application. Using wet synthesis technique, various parameters can be controlled such as purity, crystallinity, and morphology because different morphologies will be used in different application for example small spherical particle used in thermal spray coating while needle-shape or rod-shape used in bone repair composite material [4].…”

Section: -2506mentioning

confidence: 99%

Synthesis and Characterization of Hydroxyapatite Nanoparticle

Rafie

Nordin²

2017

MJAS

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In this research, hydroxyapatite (HA) nano-size powder was synthesized using wet chemical precipitation technique under atmospheric pressure where calcium hydroxide (Ca(OH) 2 ) and ortho-phosphoric acid (H 3 PO 4 ) were used as precursors. Distilled water was used as a diluting media for the reaction and sodium hydroxide (NaOH) was used to control the initial pH. The initial pH values, reaction temperature and calcined temperature play an important role in the morphology on HA as well as the phase formation and degree of crystallinity. Nano HA powder has been studied at different initial pH value which is between 9.00 to 11.00, reaction temperature from 80 °C to 100 °C and calcined temperature at 700 °C to 800 °C. The optimum initial pH value was found at pH 10.00, reaction temperature at 100 °C and calcined temperature was at 800 °C. The crystallographic properties were evaluated by X-ray diffraction (XRD), Fourier Transform Infrared (FTIR) and Field Emission Scanning Microscope (FESEM). The Design Expert version 9.0.2 with statistical and graphical analysis of the result, by using analysis of variance (ANOVA) was applied to optimize variable in the process of synthesis of HA. Based on analysis of variance (ANOVA) that has been perform, calcined temperature was to be influential variables on mass of HA with value of probability less than 0.05. Keywords: hydroxyapatite, chemical precipitation, crystallinity, morphology, optimization AbstrakDalam kajian ini, nanozarah hidroksiapatit (HA) dihasilkan melalui kaedah pemendakan di bawah tekanan atmosfera di mana kalsium hidroksida (Ca(OH) 2 ) dan asid orto fosforik (H 3 PO 4 ) merupakan larutan asas bagi penyediaan HA. Air suling digunakan sebagai agen pelarut dalam menyediakan larutan asas bagi proses pemendakan ini. Larutan natrium hidroksida di gunakan bagi mengawal nilai pH. Nilai pH, suhu tindak balas dan suhu relau merupakan faktor penting dalam pencirian dan penghabluran nanozarah HA. Nanozarah HA disediakan pada nilai pH antara 9.00 hingga 11.00, suhu tindak balas 80 °C hingga 100 °C dan suhu relau pada 700 °C hingga 800 °C. Pencirian nanozarah HA di uji menggunakan X-ray Difractometer (XRD), Inframerah Transformasi Fourier (FTIR), dan Mikroskop Pengimbas Pancaran Medan (FESEM). Perisian Design-Expert 9.0.2 digunakan untuk menganalisis data dan pengoptimuman penghasilan mendakan HA. Berdasarkan analisis varian (ANOVA) yang dilakukan, suhu relau merupakan pemboleh ubah yang mempengaruhi berat HA dengan nilai kemungkinan kurang dari 0.05.Kata kunci: hikdroksiapatit, mendakan bahan kimia, penghabluran, pencirian, pengoptimuman IntroductionTissue disease and defect, and bone disease are serious health condition that can affect the life for those who suffer on it. Since last four decades, various revolution has been introduced in order to make improvement of the uses of

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“…HA acts as a prototype for bones and teeth and is also commonly used in medical implants [14]. HA is used in the bone as nano-sized needle-like crystals.…”

Section: Hydroxyapatitementioning

confidence: 99%

Synthesis of Morphine Loaded Hydroxyapatite Nanoparticles (HAPs) and Determination of Genotoxic Effect for Using Pain Management

Kölemek

Bulduk

Ergün

et al. 2019

JPRI

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Morphine is used as a standard analgesic for intensive pain relief. It relieves acute and chronic pain by acting directly on the central nervous system and to treat myocardial infarction and shortness of breath. However, the use of morphine for the alleviation of chronic pain is controversial because of the its adverse side effects. The overall success of this medicine in chronic therapy is due to the long-term activity of the drug at a reasonable concentration. Nanoparticle-based carriers have emerged as a new class of drug delivery systems that can overcome traditional drug side-effect limitations by reducing toxicity to a minimum. In this study, a morphine-loaded HAPs drug delivery system was investigated. Fouirer Transform Infrared Spektrofotometre (FTIR) analysis was used to characterize typical functional groups found in the chemical composition of Hydroxyapatite Nanoparticles (HAPs) and morphine loaded HAPs (HAP+M). Scanning electron microscopy (SEM) and Transmission electron microscope (TEM) analyzes were performed to examine the size, morphology, and porosity of morphine loaded HAPs. Characterization analysis showed that HAP nanoparticles were loaded with morphine. The effects of pH on release of morphine-loaded HAPs was determined. The release time of the entrapped morphine in the nanoparticle increased in all conditions, thus increasing the morphine time in the human body. Thus, patients will have to take less morphine. In addition, it was investigated whether the morphine loaded HAP cell produced oxidative stress and genotoxic effect on DNA. Findings presented in this paper suggested that morphine-loaded HAPs have a promising future as a nanocarrier for pain treatment.

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Control of hydroxyapatite nanoparticle morphology using wet synthesis techniques: Reactant addition rate effects

Cited by 30 publications

References 8 publications

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Low Crystallinity Nanohydroxyapatite Prepared at Room Temperature

Synthesis and Characterization of Hydroxyapatite Nanoparticle

Synthesis of Morphine Loaded Hydroxyapatite Nanoparticles (HAPs) and Determination of Genotoxic Effect for Using Pain Management

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