Control of immunity via nutritional interventions

Collins, Nicholas; Belkaid, Yasmine

doi:10.1016/j.immuni.2022.01.004

Cited by 71 publications

(44 citation statements)

References 179 publications

(220 reference statements)

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“…Our reconstruction of some, but certainly not all, sex differences in the onset, acrophase, and amplitude of circadian rhythms in host-microbe interactions may provide guidance in selecting the right time of day to collect data. Moreover, crosstalk between microbiota and their hosts has far-reaching effects on health and disease trajectories (Belkaid and Hand, 2014; Collins and Belkaid, 2022; Helmink et al, 2019; Kostic et al, 2014; McDonald and McCoy, 2019; Round and Mazmanian, 2009). Additional experiments are now needed to consider sex differences in circadian rhythms of host-microbe interactions, and the ways in which disruption to these processes influence sex-specific disease risk.…”

Section: Discussionmentioning

confidence: 99%

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Munyoki

Goff

Mullett

et al. 2022

Preprint

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Circadian rhythms in microbial communities regulate a variety of essential homeostatic functions in the intestinal tract and distal tissues. Circadian disruption is often associated with sex-specific disease risk, but studies on circadian rhythms, the microbiome, and health outcomes primarily use male mice or collapse both sexes into one experimental condition. Here, we identify sex differences in diurnal rhythms in the intestinal microbiota, the metabolites they produce, and the expression of host genes, with more pronounced effects in females. The magnitude of these sex differences also varies by time of day, suggesting that time of collection may influence the capacity to detect sex differences in mice. Further, transitioning female mice to high-fat and low-fiber diet abolished circadian rhythms in microbiota, metabolites, and expression of host genes that is entrained by a chow diet. As a result, consumption of a high-fat and low-fiber diet generated new diurnal rhythms in the microbiota and host transcriptome in females. Together, we show that circadian rhythms in the crosstalk between microbiota and their hosts are sex-specific and that diet plays an essential role in maintaining these sex differences.

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Section: Discussionmentioning

confidence: 99%

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Munyoki

Goff

Mullett

et al. 2022

Preprint

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“…Diet has been discovered to impact the immune system (has been reviewed in ref. 168 ) The immune system uniquely contains various cell subpopulations and multiple layers with particular and complementary effectors. In response to external stimuli, including cancer and infection, the interdependent immune network endows the host with the capacity to protect against these various stimuli.…”

Section: Nutrient-associated Molecular Mechanismsmentioning

confidence: 99%

Dietary regulation in health and disease

Gao

et al. 2022

Sig Transduct Target Ther

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Nutriments have been deemed to impact all physiopathologic processes. Recent evidences in molecular medicine and clinical trials have demonstrated that adequate nutrition treatments are the golden criterion for extending healthspan and delaying ageing in various species such as yeast, drosophila, rodent, primate and human. It emerges to develop the precision-nutrition therapeutics to slow age-related biological processes and treat diverse diseases. However, the nutritive advantages frequently diversify among individuals as well as organs and tissues, which brings challenges in this field. In this review, we summarize the different forms of dietary interventions extensively prescribed for healthspan improvement and disease treatment in pre-clinical or clinical. We discuss the nutrient-mediated mechanisms including metabolic regulators, nutritive metabolism pathways, epigenetic mechanisms and circadian clocks. Comparably, we describe diet-responsive effectors by which dietary interventions influence the endocrinic, immunological, microbial and neural states responsible for improving health and preventing multiple diseases in humans. Furthermore, we expatiate diverse patterns of dietotheroapies, including different fasting, calorie-restricted diet, ketogenic diet, high-fibre diet, plants-based diet, protein restriction diet or diet with specific reduction in amino acids or microelements, potentially affecting the health and morbid states. Altogether, we emphasize the profound nutritional therapy, and highlight the crosstalk among explored mechanisms and critical factors to develop individualized therapeutic approaches and predictors.

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“…Although we have suggested the effect of fasting to intestinal DC subsets only in the present study, it has been demonstrated that effect of mild or transient restriction of dietary intake is not limited to DCs, but can affect various immune cells, such as T cells, B cells, neutrophils, macrophages, and monocytes, to modulate immune responses ( 64 ). Furthermore, fasting could increase the resistance to colonization of Salmonella Typhimurium , thus reduce host inflammatory responses through suppressing NF-κB expression and downstream inflammatory mediators in whole cecal tissue lysates ( 65 ).…”

Section: Discussionmentioning

confidence: 69%

Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice

Lee

Kim

et al. 2022

Immune Netw

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The gastrointestinal tract is the first organ directly affected by fasting. However, little is known about how fasting influences the intestinal immune system. Intestinal dendritic cells (DCs) capture antigens, migrate to secondary lymphoid organs, and provoke adaptive immune responses. We evaluated the changes of intestinal DCs in mice with short-term fasting and their effects on protective immunity against Listeria monocytogenes (LM). Fasting induced an increased number of CD103 + CD11b − DCs in both small intestinal lamina propria (SILP) and mesenteric lymph nodes (mLN). The SILP CD103 + CD11b − DCs showed proliferation and migration, coincident with increased levels of GM-CSF and C-C chemokine receptor type 7, respectively. At 24 h post-infection with LM, there was a significant reduction in the bacterial burden in the spleen, liver, and mLN of the short-term-fasted mice compared to those fed ad libitum . Also, short-term-fasted mice showed increased survival after LM infection compared with ad libitum -fed mice. It could be that significantly high TGF-β2 and Aldh1a2 expression in CD103 + CD11b − DCs in mice infected with LM might affect to increase of Foxp3 + regulatory T cells. Changes of major subset of DCs from CD103 + to CD103 − may induce the increase of IFN-γ–producing cells with forming Th1-biased environment. Therefore, the short-term fasting affects protection against LM infection by changing major subset of intestinal DCs from tolerogenic to Th1 immunogenic.

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Control of immunity via nutritional interventions

Cited by 71 publications

References 179 publications

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Circadian rhythms in the gut microbiota shape sex differences in host gene expression and metabolism

Dietary regulation in health and disease

Change of Dendritic Cell Subsets Involved in Protection Against Listeria monocytogenes Infection in Short-Term-Fasted Mice

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