Purpose:To assess the feasibility of a magnetically assisted remotecontrolled (MARC) catheter system under magnetic resonance (MR) imaging guidance for performing a simple endovascular procedure (ie, renal artery embolization) in vivo and to compare with x-ray guidance to determine the value of MR imaging guidance and the specific areas where the MARC system can be improved.
Materials and Methods:In concordance with the Institutional Animal Care and Use Committee protocol, in vivo renal artery navigation and embolization were tested in three farm pigs (mean weight 43 kg 6 2 [standard deviation]) under real-time MR imaging at 1.5 T. The MARC catheter device was constructed by using an intramural copper-braided catheter connected to a laser-lithographed saddle coil at the distal tip. Interventionalists controlled an in-room cart that delivered electrical current to deflect the catheter in the MR imager. Contralateral kidneys were similarly embolized under x-ray guidance by using standard clinical catheters and guidewires. Changes in renal artery flow and perfusion were measured before and after embolization by using velocity-encoded and perfusion MR imaging. Catheter navigation times, renal parenchymal perfusion, and renal artery flow rates were measured for MR-guided and xray-guided embolization procedures and are presented as means 6 standard deviation in this pilot study.
Results:Embolization was successful in all six kidneys under both x-ray and MR imaging guidance. Mean catheterization time with MR guidance was 93 seconds 6 56, compared with 60 seconds 6 22 for x-ray guidance. Mean changes in perfusion rates were 4.9 au/sec 6 0.8 versus 4.6 au/sec 6 0.6, and mean changes in renal flow rate were 2.1 mL/ min/g 6 0.2 versus 1.9 mL/min/g 6 0.2 with MR imaging and x-ray guidance, respectively.
Conclusion:The MARC catheter system is feasible for renal artery catheterization and embolization under real-time MR imaging in vivo, and quantitative physiologic measures under MR imaging guidance were similar to those measured under x-ray guidance, suggesting that the MARC catheter system could be used for endovascular procedures with interventional MR imaging.q RSNA, 2016