1982
DOI: 10.1002/bjs.1800690802
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Control of malignant ascites with spironolactone

Abstract: Thirteen of 15 patients with malignant ascites achieved an excellent response to spironolactone, with an increase in urinary sodium excretion rates from less than 35 mEq/d before treatment to between 50 and 245 mEq/d after treatment. Plasma renin activity was raised in all of 5 patients in whom it was measured, whereas aldosterone was raised in only 3; these results are similar to those found in ascites due to cirrhosis.

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Cited by 48 publications
(18 citation statements)
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“…Patients with liver metastases in this study tended to be given diuretics on the understanding that their ascites is likely caused by the renin-angiotensin-aldosterone pathway in some similar fashion to cirrhotic ascites. Diuretics have been shown to be more effective in the presence of liver metastases [2,12,13]. Low levels of serum albumin and total proteins are significant factors affecting survival adversely.…”
Section: Discussionmentioning
confidence: 99%
“…Patients with liver metastases in this study tended to be given diuretics on the understanding that their ascites is likely caused by the renin-angiotensin-aldosterone pathway in some similar fashion to cirrhotic ascites. Diuretics have been shown to be more effective in the presence of liver metastases [2,12,13]. Low levels of serum albumin and total proteins are significant factors affecting survival adversely.…”
Section: Discussionmentioning
confidence: 99%
“…Phase II data suggest that the efficacy of diuretics in malignant ascites depends on plasma renin/aldosterone concentration 19. In a study by Greenway and colleagues,20 13 of 15 patients responded to spironolactone (doses varying from 150 to 450 mg) and plasma renin activity was raised in all of 5 patients in whom it was measured (Table 5). …”
Section: Managementmentioning
confidence: 99%
“…Conservative treatment with diuretic therapy and sodium restriction are of little benefit [8]. Systemic chemotherapy fails in patients with RCC and is of little survival benefit (9 weeks) in patients with metastatic TCC [9].…”
Section: Discussionmentioning
confidence: 99%