Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery

Martin, Richard J.; Robertson, Alan P.

doi:10.1007/978-1-4419-6902-6_7

Cited by 40 publications

(23 citation statements)

References 89 publications

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“…For example, artemether has been reported to possess an antischistosomal effect (Abdul-Ghani et al, 2011; Xiao et al, 2011a). Others, such as pyrantel pamoate, oxantel pamoate, levamisol, mebendazole, albendazole, oxfendazole, metronidazole and piperazine, have also been reported to possess certain levels of anthelmintic effects, particularly in antinematode responses (Martin and Robertson, 2010; Beech et al, 2011; Müllner et al, 2011; van den Enden, 2009), but they showed very limited antischistosomal activities in our in vitro comparative study. The reason we did not find apparent antischistosomal effects in our experiments for these compounds may be due to our use of relatively low concentrations of the chemicals, which might have reduced the chance of observing antischistosomal activity.…”

Section: Discussionmentioning

confidence: 79%

Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

Zhang

Coultas

2013

International Journal for Parasitology: Drugs and Drug Resistan

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Graphical abstractHighlights► Only one drug (praziquantel) is available for treatment of schistosomiasis. ► Two compounds (plumbagin and sanguinarine) have shown to possess potent antischistosomal activity. ► In vitro antischistosomal effects meet the WHO’s criterion of “hit” compounds for the control of schistosomiasis. ► Morphological changes and tegumental alternations of worms treated by the two compounds are quite different.

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Section: Discussionmentioning

confidence: 79%

Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

Zhang

Coultas

2013

International Journal for Parasitology: Drugs and Drug Resistan

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“…The global market for anti-parasitic drugs of animals and humans appears to be worth tens of billions of dollars each year (e.g., Martin and Robertson, 2010). Traditionally, the search for novel drugs against parasitic nematodes has been carried out using conventional methods (e.g., the inhibition of parasite growth and/or development in vitro).…”

Section: Genomic-guided Drug Discovery and Repurposingmentioning

confidence: 99%

A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

Preston

Jabbar

Gasser

2016

Infection, Genetics and Evolution

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“…Many of the peptides in nematodes, such as the FLPs, are not found in mammals and so peptidergic signaling by these molecules can be considered a promising target for new drug discovery (Martin and Robertson, 2010). Despite the example of emodepside (Harder and von Samson-Himmelstjerna, 2002), peptides themselves are generally considered unpromising molecules from which to develop anthelmintic drugs, and so attention has focused on the use of non-peptide small molecules (Geary, 2010).…”

Section: Peptide Signaling Systemsmentioning

confidence: 99%

Ion channels and receptor as targets for the control of parasitic nematodes

Wolstenholme

2011

International Journal for Parasitology: Drugs and Drug Resistan

100

103

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Many of the anthelmintic drugs in use today act on the nematode nervous system. Ion channel targets have some obvious advantages. They tend to act quickly, which means that they will clear many infections rapidly. They produce very obvious effects on the worms, typically paralyzing them, and these effects are suitable for use in rapid and high-throughput assays. Many of the ion channels and enzymes targeted can also be incorporated into such assays. The macrocyclic lactones bind to an allosteric site on glutamate-gated chloride channels, either directly activating the channel or enhancing the effect of the normal agonist, glutamate. Many old and new anthelmintics, including tribendimidine and the amino-acetonitrile derivatives, act as agonists at nicotinic acetylcholine receptors; derquantel is an antagonist at these receptors. Nematodes express many different types of nicotinic receptor and this diversity means that they are likely to remain important targets for the foreseeable future. Emodepside may have multiple effects, affecting both a potassium channel and a pre-synaptic G protein-coupled receptor; although few other current drugs act at such targets, this example indicates that they may be more important in the future. The nematode nervous system contains many other ion channels and receptors that have not so far been exploited in worm control but which should be explored in the development of effective new compounds.

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Control of Nematode Parasites with Agents Acting on Neuro-Musculature Systems: Lessons for Neuropeptide Ligand Discovery

Cited by 40 publications

References 89 publications

Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis

A perspective on genomic-guided anthelmintic discovery and repurposing using Haemonchus contortus

Ion channels and receptor as targets for the control of parasitic nematodes

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