“…This method has been widely used with great success in problems in physics, chemistry, biology, and medicine [15] including reaction-diffusion systems [29,30,31,32,33]. In particular, it was demonstrated that it can be used to control the coherence and the timescales of noise-induced oscillations in a single FHN system [34,35,36] and in two coupled excitable FHN systems [37,38] as well as noise-induced patterns in reaction-diffusion systems [39,40,41,42] and wave propagation in excitable media [43]. This motivates our efforts to investigate whether a failure of such an intrinsic noninvasive control scheme can explain the onset of excitation spread in a spatially continuous FHN systems as a model of spreading pathological processes in the cortex during migraine and stroke.…”