Control of peptide assembly through directional interactions

Abstract

We demonstrate the self-assembly of tripeptide amphiphiles into spherical hollow capsules from linear nanoribbons via control of the molecular packing. We achieved a transition of arrangement from anisotropic to isotropic by an elaborate design of the molecular architecture.

Polyoxometalate‐Driven Self‐Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

“…Moreover, some multivalent nanofibrils have shown the propensity to selectively kill bacteria but spare tissue cells . Despite the significant application potential, the construction of those nanofibers is limited to the spontaneous assembly of β‐sheet peptides …”

Peptide π-Electron Conjugates: Organic Electronics for Biology?

“…Variation of the functional groups at the N-termini results in different morphological outcomes. 41 7…”

Polyoxometalate‐Driven Self‐Assembly of Short Peptides into Multivalent Nanofibers with Enhanced Antibacterial Activity

“…[11] Moreover,s ome multivalent nanofibrils have shown the propensity to selectively kill bacteria but spare tissue cells. [13,14] We are interested in developing multivalent peptide nanofibers with synthetic versatility beyond the reported strategy.Ithas been established that ionic self-assembly (ISA) between cationic peptides and polyanions is aconvenient and effective way to produce fibril-like nanostructures. [13,14] We are interested in developing multivalent peptide nanofibers with synthetic versatility beyond the reported strategy.Ithas been established that ionic self-assembly (ISA) between cationic peptides and polyanions is aconvenient and effective way to produce fibril-like nanostructures.…”

“…However,abisignate positive band at 197 nm together with an egative Cotton effect at 214 nm were observed in CD spectra ( Figure 2) upon the addition of H 4 SiW 12 O 40 (HSiW,F igure 1b)toan aqueous solution of L1, thus demonstrating the commencement of ac onformation transition from ar andom-coil to a b-sheet state. [13] The intensity of the negative signal at 214 nm increased gradually until am aximal b-sheet content was reached with am olar ratio of L1 to HSiW (M L1/HSiW )near 2:1. Afurther increase in the stoichiometry of HSiW led to precipitation of the material and thereby the disappearance of the CD signal.…”

“…[12] Despite the significant application potential, the construction of those nanofibers is limited to the spontaneous assembly of b-sheet peptides. [13,14] We are interested in developing multivalent peptide nanofibers with synthetic versatility beyond the reported strategy.Ithas been established that ionic self-assembly (ISA) between cationic peptides and polyanions is aconvenient and effective way to produce fibril-like nanostructures. [15,16] Moreover, polyplexes with multivalent sites have recently been prepared by controlling the charge ratio between cationic peptides and RNA.…”