Control of polymer–protein interactions by tuning the composition and length of polymer chains

Xie, Menghan; Jia, Xu; Xu, Xiao

doi:10.1039/d3cp05017c

Phys. Chem. Chem. Phys.

2024

DOI: 10.1039/d3cp05017c

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Control of polymer–protein interactions by tuning the composition and length of polymer chains

Menghan Xie,

Xu Jia,

Xiao Xu

Abstract: Nanomoduling the 3D shape and chemical functionalities in a synthetic polymer may create recognition cavities for biomacromolecule binding, which serves as an attractive alternative to natural antibodies with much less...

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Polymers for Disrupting Protein–Protein Interactions: Where Are We and Where Should We Be?

Le,

Krishna,

Gupta

et al. 2024

Biomacromolecules

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Protein–protein interactions (PPIs) are central to the cellular signaling and regulatory networks that underlie many physiological and pathophysiological processes. It is challenging to target PPIs using traditional small molecule or peptide-based approaches due to the frequent lack of well-defined binding pockets at the large and flat PPI interfaces. Synthetic polymers offer an opportunity to circumvent these challenges by providing unparalleled flexibility in tuning their physiochemical properties to achieve the desired binding properties. In this review, we summarize the current state of the field pertaining to polymer–protein interactions in solution, highlighting various polyelectrolyte systems, their tunable parameters, and their characterization. We provide an outlook on how these architectures can be improved by incorporating sequence control, foldability, and machine learning to mimic proteins at every structural level. Advances in these directions will enable the design of more specific protein-binding polymers and provide an effective strategy for targeting dynamic proteins, such as intrinsically disordered proteins.

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Polymers for Disrupting Protein–Protein Interactions: Where Are We and Where Should We Be?

Le,

Krishna,

Gupta

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

show abstract

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Control of polymer–protein interactions by tuning the composition and length of polymer chains

Abstract: Nanomoduling the 3D shape and chemical functionalities in a synthetic polymer may create recognition cavities for biomacromolecule binding, which serves as an attractive alternative to natural antibodies with much less...

Cited by 1 publication

References 56 publications

Polymers for Disrupting Protein–Protein Interactions: Where Are We and Where Should We Be?

Polymers for Disrupting Protein–Protein Interactions: Where Are We and Where Should We Be?

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