2013
DOI: 10.1159/000352043
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Control of Protein Function through Regulated Protein Degradation: Biotechnological and Biomedical Applications

Abstract: Targeted protein degradation is crucial for the correct function and maintenance of a cell. In bacteria, this process is largely performed by a handful of ATP-dependent machines, which generally consist of two components - an unfoldase and a peptidase. In some cases, however, substrate recognition by the protease may be regulated by specialized delivery factors (known as adaptor proteins). Our detailed understanding of how these machines are regulated to prevent uncontrolled degradation within a cell has permi… Show more

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Cited by 2 publications
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“…Clp is important for protein turnover and homeostasis in a broad range of species and particularly relevant under protein stress conditions, such as elevated temperatures, exposure to protein damaging agents, or during the stationary phase ( Frees et al, 2014 ). Regulatory proteolysis is the second major task of Clp, i.e., the rapid and coordinated degradation of central regulatory proteins, often transcription factors, to control differentiation and development programs of bacterial and eukaryotic cells ( Nagpal et al, 2013 ; Mahmoud and Chien, 2018 ; Nouri et al, 2020 ). In the well-studied model organism Bacillus subtilis , the Clp protease regulates, e.g., the heat-shock response, sporulation, natural genetic competence, and swarming motility ( Frees et al, 2014 ; Elsholz et al, 2017 ).…”
Section: Physiological Functions and Operation Mode Of The Clp Protease In Various Organismsmentioning
confidence: 99%
“…Clp is important for protein turnover and homeostasis in a broad range of species and particularly relevant under protein stress conditions, such as elevated temperatures, exposure to protein damaging agents, or during the stationary phase ( Frees et al, 2014 ). Regulatory proteolysis is the second major task of Clp, i.e., the rapid and coordinated degradation of central regulatory proteins, often transcription factors, to control differentiation and development programs of bacterial and eukaryotic cells ( Nagpal et al, 2013 ; Mahmoud and Chien, 2018 ; Nouri et al, 2020 ). In the well-studied model organism Bacillus subtilis , the Clp protease regulates, e.g., the heat-shock response, sporulation, natural genetic competence, and swarming motility ( Frees et al, 2014 ; Elsholz et al, 2017 ).…”
Section: Physiological Functions and Operation Mode Of The Clp Protease In Various Organismsmentioning
confidence: 99%