Control of Serum Cholesterol Homeostasis by Cholesterol in the Milk of the Suckling Rat

Reiser, Raymond; Sidelman, Zvi

doi:10.1093/jn/102.8.1009

Cited by 158 publications

(46 citation statements)

References 12 publications

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“…A new systematic review of the literature showed that breastfeeding is associated with increased mean TC and low density lipoprotein (LDL) levels in infancy but lower levels in adult life (Owen et al, 2002). This could partly be explained by the effect of early ingestion of a diet rich in cholesterol, leading to high plasma cholesterol, which in animal studies has been suggested to protect against high cholesterol challenges later in life (Reiser and Sidelman, 1972;Reiser et al, 1979;Li et al, 1980). However, the meaning of cholesterol concentration in early childhood for health in later life is still not clear, and we do not at present know what is the most favourable concentration of plasma lipids during infancy (Karlsland et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

2003

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Objective: To assess the effects of birth size, growth and feeding in infancy on serum lipids in 12-month-old infants. Design: A longitudinal observation study on infants' consumption and growth. Food and growth records were made every month. At 6, 9 and 12 months, food records were weighed to calculate intake. Serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL), low-density lipoprotein (LDL) -cholesterol and triglyceride concentrations were analysed at 12 months. Settings: Birth and growth information was gathered from maternity wards and healthcare centres in Iceland and food consumption data at home. Subjects: Randomly selected newborns (n ¼ 180) according to the mother's domicile and 77% (n ¼ 138) participated, of them 75% (n ¼ 103), came in for blood sampling. Results: Among boys, a 1 kg higher birth weight resulted in a 0.79 mmol/l higher TC (P ¼ 0.005), but nonsignificant after adjustment for growth. Duration of breastfeeding was related to LDL-cholesterol (B ¼ 0.06 70.02, P ¼ 0.020, adj. R 2 ¼ 0.039), adjusting for gender. Independent of size at birth and breastfeeding, increase in length from 6 to 12 months and in weight from birth to 12 months were negatively related to TC (B ¼ À0.45570.156, P ¼ 0.008 and B ¼ À1.08670.474, P ¼ 0.032, respecitvely) in boys. PUFA was the strongest nutrient variable predicting TC (B ¼ 0.332, adj. R 2 ¼ 0.24, P40.001). Cod liver oil consumption increased both TC and LDL-cholesterol in girls (B ¼ 0.14170.051, P ¼ 0.008 and B ¼ 0.11270.047, P ¼ 0.021, respectively). Conclusion: Slower growth of high birth weight infants and breastfeeding contributes to higher TC concentration at the age of 12 months. Nutrient intake in infancy also affects lipid profile. The effect of birth weight, growth and nutrient intake in infancy on lipid profile is different for boys and girls.

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Section: Introductionmentioning

confidence: 99%

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

2003

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“…Reiser and Sidelman (53), Sidelman (56), and Hahn and Kirby (29) investigated the problem in rats to establish whether high intakes of cholesterol in newborn and suckling rats would serve to stabilize cholesterol anabolic, catabolic, and/or transport processes so that in adulthood serum cholesterol homeostasis could be maintained at low levels during cholesterol ingestion. The adult male rats, but not females, when fed cholesterol as infants, had lower serum cholesterol concentrations than adult male rats who had received little or no cholesterol during infancy (53). Thus cholesterol intake during the suckling period may, by an unknown mechanism, establish a precedent, at least in the adult rat, for maintainance of low serum cholesterol concentration in adulthood regardless of high cholesterol intakes.…”

Section: Possible Detrimental Effects O F Early Dietary Interventionmentioning

confidence: 90%

An Interpretive Review: Diet in Early Life and the Prevention of Atherosclerosis

McBean¹,

Speckmann²

1974

Pediatr Res

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“…No such data are available for rats. It has been suggested [9,10] that high, early cholesterol intakes by rats reduced the serum cholesterol response to cholesterol feeding in later life, but other workers did not provide evidence for such an effect (11)(12)(13). The present study was undertaken to see whether in rats early feeding of a diet containing cholestyramine or cholesterol and cholate affects the later response to the intake of cholesterol plus cholate.…”

Section: Introductionmentioning

confidence: 88%

Treatment of young rats with cholestyramine or a hypercholesterolemic diet does not influence the response of serum cholesterol to dietary cholesterol in later life

1985

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SummaryGroups of 10 female Wistar rats (aged 4 weeks) were fed for 29 days either a low-cholesterol commercial diet, a commercial diet containing 2% (w/w) cholesterol, 0.5% cholate and 5% olive oil or a diet containing 2% cholestyramine. The rats were then fed the low-cholesterol commercial diet for the next 91 days and the highcholesterol diet for another 29 days. There was no significant difference between the groups in the increase of cholesterol in serum and liver during the last period of cholesterol feeding. A fourth group of 10 animals was fed the diet containing cholesterol and cholate during the entire experimental period of 149 days. By the end of the experiment serum cholesterol in these animals was lower and liver cholesterol was higher than in the 3 groups fed the high-cholesterol diet during days 120-149 of the experiment.This study does not present evidence for imprinting effects of early diet manipulation on the later cholesterolemic response to a high cholesterol diet.

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Control of Serum Cholesterol Homeostasis by Cholesterol in the Milk of the Suckling Rat

Cited by 158 publications

References 12 publications

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

An Interpretive Review: Diet in Early Life and the Prevention of Atherosclerosis

Treatment of young rats with cholestyramine or a hypercholesterolemic diet does not influence the response of serum cholesterol to dietary cholesterol in later life

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