Control of Stem‐Cell Behavior by Fine Tuning the Supramolecular Assemblies of Low‐Molecular‐Weight Gelators

Latxague, Laurent; Ramin, M.; Appavoo, Ananda; Berto, Pierre; Maisani, Mathieu; Ehret, Camille; Chassande, Olivier; Barthélémy, Philippe

doi:10.1002/anie.201409134

Cited by 100 publications

(83 citation statements)

References 45 publications

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“…The general guidelines determined in this study can be readily applied to expand this approach for the hierarchical photoinduced self‐assembly of a diversity of LMWGs, at the condition of respecting sufficient photoconversion rates (see quantum yields and two‐photon absorption cross‐section), a very low critical concentration and a self‐assembly mechanism governed by a nucleation‐growth process. LMWGs have demonstrated their potential in areas such as photonics, organic electronics, and bioprinting …”

Section: Resultsmentioning

confidence: 99%

Photocontrolled Hierarchical Self‐Assembly of Anisotropic Micropatterns of Nanofibers onto Isotropic Surfaces

Vet

Gartzia‐Rivero

Schäfer

et al. 2020

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Hierarchical self‐assembly is achieved using a visible light triggered photoreaction. A pro‐gelator, α‐diketone‐2,3‐didecyloxyanthracene, is photoconverted into a low molecular weight gelator, 2,3‐didecyloxyanthracene (DDOA), that self‐assembles into nanofibers. Spatial confinement and patterns of these nanofibers onto a surface are achieved by localizing initial nucleation with a focused laser and photogenerate subsequent fiber growth with the laser or gentler wide‐field irradiation. Remarkably, collective growth of nanofibers results in anisotropic micropatterns with orientation factors (OF) reaching 79%, resulting in collective emission of linearly polarized light. The OF, distance of collective growth and fiber density, are controlled by the photoirradiation conditions and the balance of interactions between DDOA aggregates and the glass surface. An unprecedented juxtaposition of orthogonally oriented nanofiber patterns on an isotropic surface is achieved with individual control of the fibers' main direction. In perspective, this photochemical method can be extended to a large variety of self‐assembling molecules.

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Section: Resultsmentioning

confidence: 99%

Photocontrolled Hierarchical Self‐Assembly of Anisotropic Micropatterns of Nanofibers onto Isotropic Surfaces

Vet

Gartzia‐Rivero

Schäfer

et al. 2020

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“…Among various physical stimuli, temperature‐responsive supramolecular hydrogels are the most widely studied systems, where the hydrogelators undergo sol–gel or gel–sol transitions in response to subtle changes in their surrounding temperature . Akin to thermoreversible hydrogels, the temperature‐dependent phase transitions of supramolecular hydrogels are largely driven by hydrophilic and hydrophobic interactions .…”

Section: Physical Stimuli‐responsive Hydrogelsmentioning

confidence: 99%

Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

Hoque

Sangaj

Varghese

2018

Macromolecular Bioscience

147

108

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Supramolecular hydrogels are a class of self-assembled network structures formed via non-covalent interactions of the hydrogelators. These hydrogels capable of responding to external stimuli are considered to be smart materials due to their ability to undergo sol–gel and/or gel–sol transition upon subtle changes in their surroundings. Such stimuli-responsive hydrogels are intriguing biomaterials with applications in tissue engineering, delivery of cells and drugs, modulating tissue environment to promote innate tissue repair, and imaging for medical diagnostics among others. This review summarizes the recent developments in stimuli-responsive supramolecular hydrogels and their potential applications in regenerative medicine. Specifically, various structural aspects of supramolecular hydrogelators involved in self-assembly, the role of external stimuli in tuning/controlling their phase transitions, and how these functions could be harnessed to advance applications in regenerative medicine are focused on. Finally, the key challenges and future prospects for these versatile materials are briefly described.

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“…Gel structure is maintained by weak interactions, which may depend on temperature or ionic strength and confer to the gel the possibility of a reversible gel–sol transition, that may be useful for drug delivery purposes. We previously described the development of new types of hydrogels, obtained from the self‐assembly of small amphiphilic nucleotide‐based molecules, glycol‐nucleo‐lipids (Godeau & Barthelemy, ; Godeau, Bernard, Staedel, & Barthélémy, ; Godeau, Brun, Arnion, Staedel, & Barthélémy, ; Kaplan, Barthélémy, & Grinstaff, ), that feature minimal cytotoxicity and that can be implanted or injected into animal tissues (Latxague et al, ; Ziane et al, ). In particular, gels based on glyco‐nucleo‐lipids containing a fluorinated carbon chain (GNF) have been shown to be biocompatible, eliciting a moderate inflammatory reaction and reduced fibrosis (Ziane et al, ).…”

Section: Introductionmentioning

confidence: 99%

A new composite hydrogel combining the biological properties of collagen with the mechanical properties of a supramolecular scaffold for bone tissue engineering

Maisani

Ziane

Ehret

et al. 2017

J Tissue Eng Regen Med

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Tissue engineering is a promising alternative to autografts, allografts, or biomaterials to address the treatment of severe and large bone lesions. Classically, tissue engineering products associate a scaffold and cells and are implanted or injected into the lesion. These cells must be embedded in an appropriate biocompatible scaffold, which offers a favourable environment for their survival and differentiation. Here, we designed a composite hydrogel composed of collagen I, an extracellular matrix protein widely used in several therapeutic applications, which we associated with a physical hydrogel generated from a synthetic small amphiphilic molecule. This composite showed improved mechanical and biological characteristics as compared with gels obtained from each separate compound. Incorporation of the physical hydrogel prevented shrinkage of collagen and cell diffusion out of the gel and yielded a gel with a higher elastic modulus than those of gels obtained with each component alone. The composite hydrogel allowed cell adhesion and proliferation in vitro and long-term cell survival in vivo. Moreover, it promoted the differentiation of human adipose-derived stem cells in the absence of any osteogenic factors. In vivo, cells embedded in the composite gel and injected subcutaneously in immunodeficient mice produced lamellar osteoid tissue and differentiated into osteoblasts. This study points this new composite hydrogel as a promising scaffold for bone tissue engineering applications.

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Control of Stem‐Cell Behavior by Fine Tuning the Supramolecular Assemblies of Low‐Molecular‐Weight Gelators

Cited by 100 publications

References 45 publications

Photocontrolled Hierarchical Self‐Assembly of Anisotropic Micropatterns of Nanofibers onto Isotropic Surfaces

Photocontrolled Hierarchical Self‐Assembly of Anisotropic Micropatterns of Nanofibers onto Isotropic Surfaces

Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

A new composite hydrogel combining the biological properties of collagen with the mechanical properties of a supramolecular scaffold for bone tissue engineering

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