Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

Hoque, Jiaul; Sangaj, Nivedita; Varghese, Shyni

doi:10.1002/mabi.201800259

Cited by 147 publications

(114 citation statements)

References 253 publications

(551 reference statements)

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“…As there are many ways to change the gelator structure (chemical bond formation or destruction, complexation, protonation, photochemical isomerization, etc. ), gels responding to a very broad range of stimuli have been reported 2d,43. However, the range in resulting responses is substantially smaller than for MHGs, with the majority leading to a sol–gel or gel–sol transition .…”

Section: Supramolecular or Macromolecular Functional Hydrogels?mentioning

confidence: 99%

Pros and Cons: Supramolecular or Macromolecular: What Is Best for Functional Hydrogels with Advanced Properties?

Eelkema

Pich

2020

Advanced Materials

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Herein, we lay out the pros and cons of constructing (hydro) gels from polymer networks held together by noncovalent interactions or covalent bonds. Hydrogel materials currently find many applications in personal care products, biomaterials, coatings, and plant fertilizers. They have a large potential for future application in sensing, drug delivery, soft robotics, and biohybrid or biointerfacing materials. To scientists working in those fields, the choice of material type may depend heavily on the intended application and associated required properties. There, it can be useful to consider a generalized overview and comparison of hydrogel structure, properties, and performance in various scenarios.Hydrogels are fascinating soft materials with unique properties. Many biological systems are based on hydrogel-like structures, underlining their versatility and relevance. The properties of hydrogels strongly depend on the structure of the building blocks they are composed of, as well as the nature of interactions between them in the network structure. Herein, gel networks made by supramolecular interactions are compared to covalent macromolecular networks, drawing conclusions about their performance and application as responsive materials.

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Section: Supramolecular or Macromolecular Functional Hydrogels?mentioning

confidence: 99%

Pros and Cons: Supramolecular or Macromolecular: What Is Best for Functional Hydrogels with Advanced Properties?

Eelkema

Pich

2020

Advanced Materials

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“…Especially, the stimuli-responsive drug delivery systems are promising materials for generating smart wound dressings. These materials, with the ability to tune drug release in response to stimuli of pH [71][72][73][74], temperature [71,75,76], light irradiation [11,75], electric field [77], and oxygen [11,78] hold remarkable promise for wound healing.…”

Section: Drug Loaded Electrospun Wound Dressingsmentioning

confidence: 99%

Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

162

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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“…It has to be noted that stimuli responsiveness in polymeric gels is mostly associated with swelling/shrinking processes, but in molecular gels, the response to the stimulus results commonly in gel disassembly. This property makes supramolecular gels ideal for stimuli‐triggered controlled release as shown, for example, in a recent review on this topic, or for their application in regenerative medicine …”

Section: Introductionmentioning

confidence: 96%

A Dual Stimuli Responsive Supramolecular Gel Provides Insulin Hydrolysis Protection and Redox‐Controlled Release of Actives

Navarro‐Barreda

Bedrina

Galindo

et al. 2020

Macro Chemistry & Physics

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Two supramolecular hydrogelators containing a central disulfide moiety and terminal carboxylic acid groups are studied. On the one hand, the hydrogels are responsive to a reductive environment, which transforms the disulfide unit to the corresponding thiols. On the other hand, the hydrogels show pH response associated with the presence of carboxylic acid units. Gels are formed at pH below ≈4 while at higher pH values, ionization of the gelators provokes gel disassembly. The properties of the gel are exploited for the release, as a proof of concept, of Bromophenol Blue in the presence of the reducing species tris(2‐carboxyethyl)phosphine hydrochloride. Additionally, insulin is loaded into the hydrogels and protected from hydrolysis with simulated gastric fluid containing pepsin. Quantitative release of unaltered insulin, checked with an enzyme‐linked immunosorbent assay colorimetric assay, is observed upon treatment with pH 7.4 buffer. This behavior would permit the use of the new hydrogels for oral insulin delivery.

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Stimuli‐Responsive Supramolecular Hydrogels and Their Applications in Regenerative Medicine

Cited by 147 publications

References 253 publications

Pros and Cons: Supramolecular or Macromolecular: What Is Best for Functional Hydrogels with Advanced Properties?

Pros and Cons: Supramolecular or Macromolecular: What Is Best for Functional Hydrogels with Advanced Properties?

Bio-Based Electrospun Fibers for Wound Healing

A Dual Stimuli Responsive Supramolecular Gel Provides Insulin Hydrolysis Protection and Redox‐Controlled Release of Actives

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