Control of Thyroid Hormone Activation and Inactivation by the Iodothyronine Deiodinase Family of Selenoenzymes

Zavacki, Ann Marie; Marsili, Alessandro; Larsen, P. Reed

doi:10.1007/978-1-4614-1025-6_29

Cited by 2 publications

(3 citation statements)

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“…Selenoprotein P (SelP) is the main protein within the organism responsible for Se homeostasis and transport through the body [ 8 ]. Interestingly SelP is present as two different isoforms in fish, SelPa and SelPb; they have marked differences at the structural level and likely have diverse roles in fish Se homeostasis [ 9 ]. Depending on their biological function, selenoproteins are commonly divided in two groups, essential and non-essential selenoproteins.…”

Section: Introductionmentioning

confidence: 99%

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Selenium Supplementation in Fish: A Combined Chemical and Biomolecular Study to Understand Sel-Plex Assimilation and Impact on Selenoproteome Expression in Rainbow Trout (Oncorhynchus mykiss)

et al. 2015

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BackgroundSelenium (Se) is an essential oligonutrient, as a component of several Se-containing proteins (selenoproteins), which exert important biological functions within an organism. In livestock, Se-enriched products have been proposed as dietary supplements to be included into functional feeds for animal preventive health care. To this end, it is important to understand the optimal range of concentrations for supplementation and how long it takes to be assimilated into the organism.MethodsIn this study, rainbow trout (Oncorhynchus mykiss) were fed a control diet containing 0.9 g Kg-1 Se or the same diet supplemented with a Se-Yeast product (Sel-Plex) to achieve Se concentrations ranging from 1.5–8.9 g Kg-1 for a period of ten weeks. Fish were sampled every two weeks for analysis. The kinetics of Se bioaccumulation and the effects on fish selenoprotein expression was determined in different tissues combining chemical and bimolecular techniques.ResultsThe Sel-Plex enriched diets did not have any effect on survival and growth performance. The highest Se levels were found in liver and kidney followed by muscle and blood cells. Analysis of the Se concentration factor showed that liver is able to initially regulate the amount of Se accumulated. However, with higher dietary Se level (4.8 and 8.9 g Kg-1) and longer times of exposure (10 weeks), regulation is ineffective and the Se tissue concentration increases. The expression of the selected trout selenoprotein transcripts showed an inverse correlation with Sel-Plex augmentation in most cases. In liver, kidney and blood cells the highest up-regulation of the trout selenoprotein genes was seen mostly in the group fed the diet enriched with the lowest concentration of Sel-Plex (0.5 g Kg-1) for 10 weeks.ConclusionSel-Plex may represent an excellent Se supplement to deliver a high level of Se without provoking harm to the fish and to guarantee the maximal absorption of the element. According to our results, a dietary supplementation of Sel-Plex between 0.5 and 4 g Kg-1 may allow maximal benefits, whereas 8 g Kg-1 may be excessive for the purpose of supplementation.

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Section: Introductionmentioning

confidence: 99%

“…Several biological processes rely on selenoproteins, most importantly for maintenance of antioxidant defenses, cell signaling, thyroid hormone metabolism and immune responses [ 9 – 13 ]. A severe Se deficiency can impair selenoprotein functioning and consequently can impact on an organism’s health status.…”

Section: Introductionmentioning

confidence: 99%

Selenium Supplementation in Fish: A Combined Chemical and Biomolecular Study to Understand Sel-Plex Assimilation and Impact on Selenoproteome Expression in Rainbow Trout (Oncorhynchus mykiss)

et al. 2015

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“…Selenium is an important trace element that exerts its biological functions including structural, catalytic, and antioxidative roles through the biosynthesis and the activation of selenoenzymes and selenoproteins (e.g., glutathione peroxidase and thioredoxin reductases) [11,12]. Furthermore, Se has vital role in cell signaling, metabolism of thyroid hormones, and immunocompetence of organisms [13][14][15][16][17]. Up to 41 selenoproteins have been so far identified in teleosts [18].…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Related Semen Quality and Fertility in the Male Arabian Yellowfin Sea Bream (Acanthopagrus arabicus) Fed a Selenium Nanoparticle-Supplemented Plant Protein-Rich Diet

Khademzade

Kochanian

Zakeri

et al. 2022

Aquaculture Nutrition

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A three-month research was conducted to evaluate the influence of supplementing a plant protein- (PP-) rich diet (60% of fish meal (FM) was replaced with a mixture of alternative PP sources) with selenium nanoparticles (Se-N) on sperm kinetics, fertilization capacity, and antioxidative responses in Arabian yellowfin sea bream (Acanthopagrus arabicus) males. In this point, graded levels of Se-N at 0, 0.5, 1, 2, and 4 mg/kg were added to the PP-rich diet. Also, a FM-based diet was used as a positive control. Two hundred and eighty-eight brooders (males: 195.3 ± 10.8 g and females: 237.5 ± 8.1 g; mean ± standard error ) were randomly distributed into eighteen 10 m3 rectangular concrete tanks (8 males: 8 females in each tank), and every three tanks were fed with one of the experimental feeds for three months. The seawater temperature and salinity were 18-22°C and 40-41‰, respectively, during the husbandry period. Selenium retention increased in the liver, testes, and semen of males with increasing dietary Se-N level ( P < 0.05 ). Sperm density in fish fed with 2 mg Se-N/kg PP-rich diet ( 42.1 × 10 9 / mL ) was higher than those fed control, 0, 0.5, and 1 mg Se-N/kg PP-rich diets. The percentages of sperm motility in 60 s and 300 s after activation, sperms with straight movement, the longevity of sperm motility, and fertilization rate increased with increasing Se-N level in the PP-rich diets ( P < 0.05 ). The highest and lowest semen superoxide dismutase activities were in fish fed 4 and 2 mg Se-N/kg PP-rich diets, respectively. The highest glutathione peroxidase activity in semen was in fish fed 4 mg Se-N/kg PP-rich diet, and the lowest values were in fish fed 0 and 0.5 mg Se-N/kg PP-rich diets. Total antioxidant capacity values in semen of fish fed 1 and 4 mg Se-N/kg PP-rich diets were higher than the other treatments. Fish fed with PP-rich diet without any Se-N supplementation had higher malondialdehyde level in the semen compared to the other groups. Results showed that supplementing PP-rich diet with 2-4 mg Se-N/kg can improve sperm kinetics and enhance fertility potential in A. arabicus males.

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Control of Thyroid Hormone Activation and Inactivation by the Iodothyronine Deiodinase Family of Selenoenzymes

Cited by 2 publications

References 53 publications

Selenium Supplementation in Fish: A Combined Chemical and Biomolecular Study to Understand Sel-Plex Assimilation and Impact on Selenoproteome Expression in Rainbow Trout (Oncorhynchus mykiss)

Selenium Supplementation in Fish: A Combined Chemical and Biomolecular Study to Understand Sel-Plex Assimilation and Impact on Selenoproteome Expression in Rainbow Trout (Oncorhynchus mykiss)

Oxidative Stress-Related Semen Quality and Fertility in the Male Arabian Yellowfin Sea Bream (Acanthopagrus arabicus) Fed a Selenium Nanoparticle-Supplemented Plant Protein-Rich Diet

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