Selective weed control in ornamental plant production can be difficult as many herbicides can cause unacceptable injury. Research was conducted to evaluate the tolerance of several ornamental species to applications of p-hydroxyphenylpyruvate dioxygenase (HPPD)-inhibiting herbicides for the control of problematic weeds in ornamental production. Mestotrione (0.09, 0.18, and 0.36 lb/acre), tembotrione (0.08, 0.16, and 0.32 lb/acre), and topramezone (0.016, 0.032, and 0.064 lb/acre) were applied alone postemergence (POST) in comparison with the photosystem II-inhibiting herbicide, bentazon (0.5 lb/acre). All herbicide treatments, with the exception of the two highest rates of tembotrione, caused less than 8% injury to ‘Noble Upright’ japanese holly (Ilex crenata) and ‘Compactus’ burning bush (Euonymus alatus). Similarly, no herbicide treatment caused greater than 12% injury to ‘Girard’s Rose’ azalea (Azalea). Conversely, all herbicides injured flowering dogwood (Cornus florida) 10% to 23%. Mesotrione- and tembotrione-injured ‘Radrazz’ rose (Rosa) 18% to 55%, compared with only 5% to 18% with topramezone. ‘Siloam June Bug’ daylily (Hemerocallis) injury with topramezone and tembotrione was less than 10%. Topramezone was the only herbicide evaluated that provided at least 93% control of redroot pigweed (Amaranthus retroflexus) with all application rates by 4 weeks after treatment (WAT). Redroot pigweed was controlled 67% to 100% with mesotrione and tembotrione by 4 WAT, but this activity was variable among application rates. Spotted spurge (Chamaesyce maculata) was only adequately controlled by mesotrione applications at 0.18 and 0.36 lb/acre, whereas chamberbitter (Phyllanthus urinaria) was not controlled sufficiently with any herbicide evaluated in these studies. Yellow nutsedge (Cyperus esculentus) was suppressed 72% to 87% with mesotrione applications at 0.18 lb/acre or higher and with bentazon at 0.5 lb/acre by 4 WAT. All other herbicide treatments provided less than 58% control of yellow nutsedge. In the second study, ‘Patriot’ hosta (Hosta), ‘Green Sheen’ pachysandra (Pachysandra terminalis), autumn fern (Dryopteris erythrosora), ‘Little Princess’ spirea (Spiraea japonica), ‘Green Giant’ arborvitae (Thuja plicata), and ‘Rosea’ weigela (Weigela florida) displayed no response to topramezone when applied at 0.024 and 0.095 lb/acre. Since 10 ornamental species in our studies exhibited less than 10% herbicidal response with all rates of at least one HPPD-inhibiting herbicide then it is possible that these herbicides may provide selective POST weed control in ornamental production systems.