This paper proposes model reduction techniques for reducing engine airpath models in real-time (RT), for a control oriented application in an engine equipped with high pressure exhaust gas recirculation (EGR-HP) and single stage turbocharger. There are two major challenges addressed by authors: First, reducing the order without compromising the performance in terms of accuracy by decoupling the nonlinear coupled differential equations of airpath system in-order to use them in real-time processor-in-loop control application. A model reduction technique based on different dynamic characteristics between thermodynamic states followed by semi-implicit Euler (SIE) numerical method to solve coupled dynamic multi-input multi-output (MIMO) differential equation models is demonstrated. Second, the authors have proposed a novel method to calculate gas mass flow via compressor, coupled with engine airpath model in real-time. The proposed models of airpath system coupled with turbocharger models for a diesel engine is validated with experimental data to evaluate performance of pressures, temperatures, mass flows at relevant components. The developed airpath model is used for calculating thermodynamic properties in real-time for state of art engine control unit (ECU) in production engine and become basis for feedforward as well as closed loop control of airpath variables for real-time system. Authors further propose to use this modeling approach for calculating airpath system variables for exhaust aftertreatment system, injection system, and for virtualization of sensor values in airpath systems.