The aims of the study were to evaluate the control of botrytis in the soybean stem, spraying homeopathic solutions of Sulphur and Nosode of Macrophomina phaseolina in the dynamizations 6, 12, 24, 36 and 48CH. As additional treatment, we used distilled water and hydroalcoholic solution at 30% ethanol. In vitro tests were performed so as to analyze the number of micro-sclerotia and mycelial growth of the fungi, and in vivo tests to track the progress of the botrytis stem and the size of the lesion. The experimental design was in randomized blocks, with five replications. For the area under the mycelial growth curve (AUMGC) in the first test, there was no significant effect of Sulphur and Nosode of M. phaseolina. In vivo studies, comparing Sulphur with the control treatment, showed a reduction of 14 and 15% for the dynamizations of 12 and 48 CH, respectively. For the amount of micro-sclerotia of M. phaseolina, in the first test, Sulphur showed a reduction of up to 50%; Nosode of M. phaseolina showed no significant reduction of micro-sclerotia. In the second test, Nosode was not significant while Sulphur caused a reduction of up to 33%. For area under the disease progress curve (AUDPC), in both trials, the drugs proved to be ineffective. These results indicate the potential of these homeopathic remedies in controlling the fungus, M. phaseolina.