Controle de qualidade de uma formulação de enxaguatório bucal à base de Libidibia Ferrea L.

Abstract

Controle de qualidade de uma formulação de enxaguatório bucal à base deLibidibia Ferrea L.Quality control of a formulation mouthwash based on Libidibia Ferrea L.

Antimicrobial activity and quality control of a formulation based on Libidibia ferrea after aging

“…There was no indication of the presence of microorganisms (bacteria, fungi or yeasts) Salmonella sp., Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. They were corroborated with Venâncio et al (2015) and Souza et al (2020), since there was no indication of the presence of microorganisms in all intervals in the studies performed.…”

“…As for density, in the results by Venâncio et al (2015), it was found that the variation was acceptable in the initial experimental periods, noticing a statistical difference over time, when the Tukey test was performed, but without interfering in the final formulation characteristic. The results by Souza et al (2020) regarding sedimentation found that there was no statistically significant difference when comparing sample times and storage environments. Corresponding to the results obtained in the test performed after 24 months, an average of 1.029 g / cm³ was gathered, which did not present a statistically significant difference about the time of 60, 90, 120, and 180 days.…”

“…The results obtained by Marreiro et al (2014a), also showed a decrease in the average pH values of the tested juca mouthwash during the experiment, with a statistically significant difference in pH, at the level of 5%, between the periods of 0 and 60 days, however, in the periods from 0 to 30 days and 30 to 60 days, this statistical difference was not observed when the Tukey test was performed, with the pH of the formulation around 5.5. According to Souza et al (2020), when comparing subsequent sample periods, there was a statistically significant pH difference in the periods of 60-90 (p <0.001).…”

“…It concluded that the mouthwash showed stability conditions, as well as the absence of contaminants. In continuity, Souza et al (2020) analyzed the formulation above to assess pharmacological stability, in three storage conditions (room temperature, air conditioning, and refrigerator) and in six time intervals (0, 30, 60, 90, 120 and 180 days) presenting favorable conditions of stability and absence of contaminants. Thus, the present study aimed to evaluate, in vitro, the same formulation analyzed in the study by Venâncio et al (2015) and Souza et al (2020), verifying if its characteristics remained stable after 24 months.…”

“…L. ferrea has shown, through the results of studies, great potential, pointing to its use as a mouthwash aiming at the control of dental biofilm Souza et al, 2020), a factor related to periodontal infections and dental caries, which are arguably the most common infectious pathologies in the oral cavity (Ferreira et al, 2013).…”