Contrôle génétique de la squelettogenèse

Ducy, Patricia

doi:10.1051/medsci/200117121242

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…In fact, palatine suture obliteration both starts later and progresses more slowly, which underlines its interest in the study of skeletal remains of elderly subjects. There is no clear explanation for these phenomena but various transcription factors, growth factors, and their receptors are currently put forward (45–50). Nevertheless, even if we observed a later and slower progression of palatine suture fusion, when compared to vault sutures, there was more than 85% concordance between both estimations.…”

Section: Discussionmentioning

confidence: 99%

Palatine Sutures as Age Indicator: A Controlled Study in the Elderly

Beauthier

Lefèvre

Meunier

et al. 2010

Journal of Forensic Sciences

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Vault sutures have proven their low reliability for estimating age at death in individual forensic science cases. We broke down the palatine sutures of 134 skulls (with known sex and age at time of death) into 15 subparts and 5 stages of fusion to obtain a mean coefficient of obliteration (Cp) which was then linked to five age classes. We completed this study with multiple regression equations of total palatine suture scores. We compared our results with those obtained using the Mann method on the one hand and classically segmented and scored ectocranial suture age determination methods on the other. Palatine sutures generally do not estimate age at death any better than cranial vault sutures. Despite the partly subjective aspect of suture study, palatine suture observation contributes additional information to age-range estimation, especially in old and very old subjects where other methods lose their effectiveness.

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Section: Discussionmentioning

confidence: 99%

Palatine Sutures as Age Indicator: A Controlled Study in the Elderly

Beauthier

Lefèvre

Meunier

et al. 2010

Journal of Forensic Sciences

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“…We are, however, not aware of any specific genes or proteins that might have a role in determining the overall sequence of ossification of the skull bones. Karsenty (1998, , p. 303) specifically stated the following: “As of now, no clear genetic cascade has emerged to explain patterning of the head, the axial or the appendicular skeleton.” Except for many studies of premature closure of cranial sutures in mammals, this continues to be the case (Ducy 2001).…”

Section: Development and Evolutionmentioning

confidence: 99%

Ontogenetic evidence for the Paleozoic ancestry of salamanders

Schoch

Carroll

2003

Evolution and Development

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The phylogenetic positions of frogs, salamanders, and caecilians have been difficult to establish. Data matrices based primarily on Paleozoic taxa support a monophyletic origin of all Lissamphibia but have resulted in widely divergent hypotheses of the nature of their common ancestor. Analysis that concentrates on the character states of the stem taxa of the extant orders, in contrast, suggests a polyphyletic origin from divergent Paleozoic clades. Comparison of patterns of larval development in Paleozoic and modern amphibians provides a means to test previous phylogenies based primarily on adult characteristics. This proves to be highly informative in the case of the origin of salamanders. Putative ancestors of salamanders are recognized from the Permo-Carboniferous boundary of Germany on the basis of ontogenetic changes observed in fossil remains of larval growth series. The entire developmental sequence from hatching to metamorphosis is revealed in an assemblage of over 600 specimens from a single locality, all belonging to the genus Apateon. Apateon forms the most speciose genus of the neotenic temnospondyl family Branchiosauridae. The sequence of ossification of individual bones and the changing configuration of the skull closely parallel those observed in the development of primitive living salamanders. These fossils provide a model of how derived features of the salamander skull may have evolved in the context of feeding specializations that appeared in early larval stages of members of the Branchiosauridae. Larvae of Apateon share many unique derived characters with salamanders of the families Hynobiidae, Salamandridae, and Ambystomatidae, which have not been recognized in any other group of Paleozoic amphibians.

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“…First of all, osteoclasts differentiation cannot occur without their interaction with other bone cells (mainly osteoblasts, and bone marrow or stromal cells) [7,63,64]. In addition, the chemotactic recruitment of osteoclasts, and their further development, are supported by several cytokines and hormones, such as interleukines (IL1, IL6, IL11), the receptor RANK (receptor activator of NF-kB factor), the colony stimulating factors-1 (CSF-1), proteins from the tumor necrosis factor superfamily (TNFα, RANKL), paratormone (PTH), 1,25-(OH)2-Vitamin D, and calcitonin [7,65,66]. RANKL is crucial for the osteoclastogenesis and for the survival and function of osteoclasts [67].…”

Section: Bone Cell Typesmentioning

confidence: 99%