Controllable Design of Naked and Poly(Amine)-Capped Porous and Nonporous Microparticles of Sustainable Polymers That Exhibit Dual Modalities for Volatile Organic Compound Adsorption

Attia, Mohamed F.; Swasy, Maria I.; Alexis, Frank; Whitehead, Daniel C.

doi:10.1021/acsapm.9b00953

Cited by 2 publications

(2 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PMO1 (control), PMO2, and PMO3 were synthesized using DMF as described above, while PMO4 was prepared using toluene in place of DMF to produce particles with different morphologies. Poly(ethylene glycol)- co -poly( d , l -lactic acid) (PEG–PDLLA) polymer was synthesized following a standard ring-opening polymerization method as previously reported. , PEG–PDLLA was incorporated with starting materials in different concentrations with regard to BTEB for yielding PMO2 (BTEB/PEG–PDLLA = 85:15) and PMO3 (BTEB/PEG–PDLLA = 75:25).…”

Section: Methodsmentioning

confidence: 99%

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Attia

Akasov

Alexis

et al. 2020

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

We developed four types of para-phenylene-bridged periodic mesoporous organosilica NPs (p-P PMO NPs) with tailored physical parameters including size, morphology, porosity, and surface area using a new polymer-scaffolding approach. The particles have been formulated to facilitate the codelivery of small-molecule hydrophobic/hydrophilic cargos such as model anticancer drugs (i.e., doxorubicin hydrochloride (DOX) and O 6-benzylguanine) and model fluorescent dyes (i.e., rhodamine 6G and Nile red). p-P PMO NPs were synthesized via a cetyltrimethylammonium bromide (CTAB)-directed sol–gel process using two different organic solvents and in the presence of polymeric scaffolding constituents that led to morphologically distinct PMO NPs despite using the same organosilane precursors. After the formulation process, the polymeric scaffolding agent was conveniently washed away from the PMO NPs. Extensive analyses were used to characterize the physicochemical attributes of the PMO NPs such as their chemical composition, morphologies, etc. Spherical and rod-shaped PMOs of diameters ranging between 79 and 342 nm, surface areas between 770 and 1060 m2/g, and pore volumes between 0.79 and 1.37 cm3/g were prepared using the polymer-scaffolding approach. The performance of these materials toward drug-loading capacity, cytotoxicity, and cancer cell internalization was evaluated. Interestingly, the designed particles exhibited significantly high payloads of drugs and dyes (up to 78 and 94%, respectively). Cellular studies also demonstrated exceptional biocompatibility and marked internalization into both human breast cancer MCF-7 and glioblastoma U-87 MG cells. Further, DOX also possessed a noticeable release from particles and accumulation in cell nuclei with increased incubation time in vitro. Ultimately, this work validates the controlled design and synthesis of PMO NPs using a polymer-scaffolding approach and highlights the potential of these materials as excellent delivery systems for combination therapy with high loading capability to improve the therapeutic index for cancers.

show abstract

Section: Methodsmentioning

confidence: 99%

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Attia

Akasov

Alexis

et al. 2020

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our laboratory has had a long-standing interest in exploring functional nano- and micro-scale materials for environmental remediation [ 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. Recently, we developed a route to access poly(ethylenimine)-modified cellulose nanocrystals (PEI- f -CNC) that are capable of capturing volatile organic compounds associated with odors [ 22 ] and degrading common pesticides from water [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Scaled Synthesis of Polyamine-Modified Cellulose Nanocrystals from Bulk Cotton and Their Use for Capturing Volatile Organic Compounds

et al. 2021

Self Cite

View full text Add to dashboard Cite

We have previously demonstrated that cellulose nanocrystals modified with poly(ethylenimine) (PEI-f-CNC) are capable of capturing volatile organic compounds (VOCs) associated with malodors. In this manuscript, we describe our efforts to develop a scalable synthesis of these materials from bulk cotton. This work culminated in a reliable protocol for the synthesis of unmodified cellulose nanocrystals (CNCs) from bulk cotton on a 0.5 kg scale. Additionally, we developed a protocol for the modification of the CNCs by means of sequential 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO) oxidation and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) coupling to modify their surface with poly(ethylenimine) on a 100 g scale. Subsequently, we evaluated the performance of the PEI-f-CNC materials that were prepared in a series of VOC capture experiments. First, we demonstrated their efficacy in capturing volatile fatty acids emitted at a rendering plant when formulated as packed-bed filter cartridges. Secondly, we evaluated the potential to use aqueous PEI-f-CNC suspensions as a spray-based delivery method for VOC remediation. In both cases, the PEI-f-CNC formulations reduced detectable malodor VOCs by greater than 90%. The facile scaled synthesis of these materials and their excellent performance at VOC remediation suggest that they may emerge as a useful strategy for the remediation of VOCs associated with odor.

show abstract

Controllable Design of Naked and Poly(Amine)-Capped Porous and Nonporous Microparticles of Sustainable Polymers That Exhibit Dual Modalities for Volatile Organic Compound Adsorption

Cited by 2 publications

References 57 publications

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Polymer-Scaffolded Synthesis of Periodic Mesoporous Organosilica Nanomaterials for Delivery Systems in Cancer Cells

Scaled Synthesis of Polyamine-Modified Cellulose Nanocrystals from Bulk Cotton and Their Use for Capturing Volatile Organic Compounds

Contact Info

Product

Resources

About