Controllable morphology and wettability of polymer microspheres prepared by nonsolvent assisted electrospraying

Gao, Jiefeng; Wan, Li; Wong, Julia Shuk-Ping; Hu, Mingjun; Li, Robert K.Y.

doi:10.1016/j.polymer.2014.04.033

Cited by 41 publications

(28 citation statements)

References 53 publications

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“…According to previous experiments conducted by Gao et al, non-solvents with higher surface tensions tend to diffuse into the centre of a droplet; non-solvents with lower viscosities tend to coalesce mutually and are conducive to nuclei growth. However, taking into account the molecular weight of non-solvents, relatively larger molecules will hinder the mass transfer rate and, thus, hinder nuclei growth [13]. Therefore, although methanol, ethanol, n-butanol and TEOS possess similar surface tensions, MPs prepared using P met and P eth (with lower molecular weights) exhibit deeper and connected pores compared to P but and P teos (larger molecular weight).…”

Section: Resultsmentioning

confidence: 99%

“…More recently, porous polymethylmethacrylate (PMMA)-based microstructures were obtained using several non-solvents and solvent (dichloromethane (DCM)) mixtures (suspensions) via co-ES. In this instance, both solid and hollow MPs with a porous surface topology were formed [13]. While the use of multiple non-solvents (for material dissolution) and multiple nozzles (e.g., co-axial methods) is valuable, the complexity of these systems will contribute towards greater costs and additional parameter analysis (both for output and pre-process characterization) [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Tuning Microparticle Porosity during Single Needle Electrospraying Synthesis via a Non-Solvent-Based Physicochemical Approach

et al. 2015

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Porous materials, especially microparticles (MP), are utilized in almost every field of engineering and science, ranging from healthcare materials (drug delivery to tissue engineering) to environmental engineering (biosensing to catalysis). Here, we utilize the single needle electrospraying technique (as opposed to complex systems currently in development) to prepare a variety of poly(ε-caprolactone) (PCL) MPs with diverse surface morphologies (variation in pore size from 220 nm to 1.35 µm) and architectural features (e.g., ellipsoidal, surface lamellar, Janus lotus seedpods and spherical). This is achieved by using an unconventional approach (exploiting physicochemical properties of a series of non-solvents as the collection media) via a single step. Sub-micron pores presented on MPs were visualized by electron microscopy (demonstrating a mean MP size range of 7-20 µm). The present approach enables modulation in morphology and size requirements for specific applications (e.g., pulmonary delivery, biological scaffolds, multi-stage drug delivery and biomaterial topography enhancement). Differences in static water contact angles were observed between smooth and porous MP-coated surfaces. This reflects the hydrophilic/hydrophobic properties of these materials.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tuning Microparticle Porosity during Single Needle Electrospraying Synthesis via a Non-Solvent-Based Physicochemical Approach

et al. 2015

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“…Usually, porous microparticles can be fabricated by creating pores from templates such as assembled surfactants (Zhou, Gu, Su, & Ma, 2007), emulsion droplets (Edwards et al, 1997), bubbles (Kim, Yoon, Lee, & Park, 2006), and phase separation spaces (Gao, Li, Wong, Hu, & Li, 2014) in the precursors of microparticles. Such pore templates can be simply applied to microfluidic emulsion droplets to produce controllable microparticles with tunable porous structures.…”

Section: Microfluidic Fabrication Of Porous Microparticlesmentioning

confidence: 99%

Controllable microfluidic strategies for fabricating microparticles using emulsions as templates

et al. 2016

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“…A solid PBS shell is expected to be formed as a consequence of the rapid evaporation of the solvent. Nevertheless, this shell should easily collapse since the core of the particle is structurally weak due to the low polymer concentration [54]. Electrospraying parameters were modified when a solution of dichloromethane was employed.…”

Section: Optimization Of Operational Conditions For Electrospraying Omentioning

confidence: 99%

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

Murase

Aymat

Calvet

et al. 2015

European Polymer Journal

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Electrospraying of poly(butylene succinate) and its mixture with different indole derivatives was successfully performed using chloroform as solvent and relatively low flow rates and concentrations. Morphology of particles (size, diameter distribution and surface texture) and encapsulation efficiency were dependent on the loaded drug and specifically on the type of substituent (methyl or phenyl) and its position in the indole core. In general, particles showed a raisin-like morphology caused by the shell collapsing of the resulting structurally weak microspheres. Accumulation of electrosprayed particles gave rise to consistent mats and they had a more hydrophobic surface than that determined for smooth films. The increase of hydrophobicity was mainly dependent on the porosity and the hydrophobic nature of the incorporated drugs. Indole derivatives were hardly delivered in a standard phosphate saline buffer due to their scarce solubility in aqueous media but the addition of ethanol caused a drastic change in the release behavior. This was generally characterized by a fast burst effect and followed by the establishment of an equilibrium condition that was dependent on the indole derivative. However, a clearly different behavior was found when the indole was unable to form hydrogen bonds (e.g. 1-methylindole) since in this case a slow and sustained release was characteristic. Microspheres loaded with indole derivatives showed a high antiproliferative activity that was dependent on encapsulation efficiency and the type of loaded drug. The best results were specifically attained for the indole with an aromatic substituent. Interestingly significant differences were found between cancer and immortalized cells, a feature that points out the potential use of such systems for cancer prevention and treatment. (C) 2015 Elsevier Ltd. All rights reserved.Postprint (author's final draft

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Controllable morphology and wettability of polymer microspheres prepared by nonsolvent assisted electrospraying

Cited by 41 publications

References 53 publications

Tuning Microparticle Porosity during Single Needle Electrospraying Synthesis via a Non-Solvent-Based Physicochemical Approach

Tuning Microparticle Porosity during Single Needle Electrospraying Synthesis via a Non-Solvent-Based Physicochemical Approach

Controllable microfluidic strategies for fabricating microparticles using emulsions as templates

Electrosprayed poly(butylene succinate) microspheres loaded with indole derivatives: A system with anticancer activity

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