Controllable synthesis of hydroxyapatite nanocrystals via a dendrimer-assisted hydrothermal process

Zhou, Zhuo-Hua; Zhou, Peiru; Yang, Shiping; Yu, Xiaojiang; Yang, Ling

doi:10.1016/j.materresbull.2006.11.041

Cited by 69 publications

(42 citation statements)

References 28 publications

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“…One possibility is that PAMAM-MG serves as nucleation site, which leads to the binding of Ca 2? to the carboxylic acid groups on the PAMAM-MG surface. Such an interaction was reported by Khopade et al [25] and Zhou et al [18]. Zhou indicated that when -COOH-terminated PAMAM dendrimers were mixed with Ca 2?…”

Section: Crystal Morphologiessupporting

confidence: 63%

“…Another possible interaction involves the interior dendritic branches, such as N-H, which are also able to coordinate with Ca 2? ions as confirmed by FT-IR [18]. The narrowing of the rectangular crystals was likely due to the absorbance of PAMAM on specific mineral surfaces.…”

Section: Crystal Morphologiesmentioning

confidence: 58%

“…Moreover, PAMAM G3.5 was used to prepare a CaCO 3 /poly(ethylenimine) composite film, whereas without any PAMAM or with PAMAM G1.5, composite films could not be formed [14]. Recently, PAMAM with different termini were used to investigate the interaction between protein and hydroxyapatite (Ca 5 (PO 4 ) 3 OH, HAP) [15,16] and the synthesis of nanocrystalline (nano)-HAP [17][18][19]. PAMAM with terminal groups of -NHC(O)CH 3 , -COOH, and -NH 2 were used as probes to study the alternating bands of charge distribution of natural enamel HAP crystals [15].…”

Section: Introductionmentioning

confidence: 99%

“…PAMAM with terminal groups of -NHC(O)CH 3 , -COOH, and -NH 2 were used as probes to study the alternating bands of charge distribution of natural enamel HAP crystals [15]. Zhou et al found that the morphology and size of HAP were affected differently by carboxylic-terminated PAMAM and by polyhydroxyterminated PAMAM under hydrothermal treatment due to the different nucleation sites and adsorption onto the crystal surface [18]. Another study conducted by Yan et al showed a PAMAM concentration dependent size change of ellipsoid-like HAP crystals synthesized by the hydrothermal method in the presence of PAMAM G4.0 with amido groups [17].…”

Section: Introductionmentioning

confidence: 99%

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Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

et al. 2010

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Second generation poly(amidoamine) (PAMAM) dendrimers were synthesized and peripherally modified with glutamic acid (PAMAM-MG) as a shell. The effect of the dendrimers on the crystallization of different calcium phosphate compounds was investigated in both double and one way diffusion systems. It was found that the crystals of calcium phosphate showed tape-like morphology in the presence of PAMAM-MG, and the crystals' thickness and width decreased compared to those grown without dendritic molecules. Such a result might be due to the interaction of electric charges between dendritic molecules and octacalcium phosphate (Ca 8 H 2 (PO 4 ) 6 Á5H 2 O, OCP), which led to the adsorption of PAMAM-MG in the 100 and 010 surfaces of OCP. Moreover, PAMAM-MG showed an affinity for gelatin, and it could cause the formation of amorphous calcium phosphate (Ca 9 (PO 4 ) 6 ÁnH 2 O, ACP) at a concentration of 5 mg/mL of PAMAM-MG. These results suggest that PAMAM-MG could be used for regulating the morphology of OCP and changing the composition of minerals in gels.

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Section: Crystal Morphologiessupporting

confidence: 63%

Section: Crystal Morphologiesmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

et al. 2010

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“…Inspection of all images reveals the presence of spherical particle morphology in all samples produced, this is similar to the particle morphologies reported in the literature. 39,[55][56][57][58][59] The mean particle sizes determined from the FESEM images are tabulated in Table 2. These particle sizes compare favorably with those calculated from the XRD spectra.…”

Section: X-ray Diffraction Spectroscopymentioning

confidence: 99%

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Poinern¹,

Brundavanam²,

Le³

et al. 2011

IJN

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Hydroxyapatite (HAP) is a widely used biocompatible ceramic in many biomedical applications and devices. Currently nanometer-scale forms of HAP are being intensely investigated due to their close similarity to the inorganic mineral component of the natural bone matrix. In this study nano-HAP was prepared via a wet precipitation method using Ca(NO 3 ) 2 and KH 2 PO 4 as the main reactants and NH 4 OH as the precipitator under ultrasonic irradiation. The Ca/P ratio was set at 1.67 and the pH was maintained at 9 during the synthesis process. The influence of the thermal treatment was investigated by using two thermal treatment processes to produce ultrafine nano-HAP powders. In the first heat treatment, a conventional radiant tube furnace was used to produce nano-particles with an average size of approximately 30 nm in diameter, while the second thermal treatment used a microwave-based technique to produce particles with an average diameter of 36 nm. The crystalline structure and morphology of all nanoparticle powders produced were investigated using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FT-IR). Both thermal techniques effectively produced ultrafine powders with similar crystalline structure, morphology and particle sizes.

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Research Progress in Biomimetic Materials for Human Dental Caries Restoration

Wang

Liu

Habib

et al. 2018

Bioinspired Materials Science and Engineering

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Controllable synthesis of hydroxyapatite nanocrystals via a dendrimer-assisted hydrothermal process

Cited by 69 publications

References 28 publications

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

Effects of glutamic acid shelled PAMAM dendrimers on the crystallization of calcium phosphate in diffusion systems

Thermal and ultrasonic influence in the formation of nanometer scale hydroxyapatite bio-ceramic

Research Progress in Biomimetic Materials for Human Dental Caries Restoration

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