“…Electron microscopy showed that claudin‐5, occludin, and ZO‐1 decreased after sonication in rats, and gradually returned to presonication levels (Liu, Gong, et al, 2020). Ultrasound‐mediated BBB opening has been applied to deliver conventional chemotherapeutic drugs and nanoparticles for the treatment of malignant gliomas and metastatic brain tumors (Liu, Ren, et al, 2019; Liu, Wu, et al, 2019; Ren et al, 2020; Wang, Zhang, et al, 2022; Xu et al, 2022; Yuan et al, 2022; Zhang et al, 2018).…”