Controlled adsorption and release of amoxicillin in GO/HA composite materials

Abstract

Present work is aimed at preparing hybrid composites based on graphene oxide and hydroxyapatite as a matrix (GO/ HA), which can be used as a template for drug delivery after chirurgical operation. Composite materials were synthesized through an in situ precipitation as simple and save-time method. The obtained materials were characterized using infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and X-ray diffraction (XRD). Hybrid materials were loaded with amoxicillin and the drug delivery during various periods of time was assessed with UV spectroscopy. During loading periods, it was noted that GO has a much larger cumulative drug concentration compared to hydroxyapatite and other composites. Similarly, and during the release process, amoxicillin is released much faster during the earlier stage of immersion before reaching a stationary state towards long periods of time. This variation was found to be dependent on the amount of GO in the HA matrix, as well as on the number of oxygen available on the GO sheets and the HA surfaces.

Acellular bioactivity and drug delivery of new strontium doped bioactive glasses prepared through a hydrothermal process

“…The release behavior is explained by the drug matrix mixture compression (diffusion constraints) and the surface area and pore volume of bioactive glass, which induce a slow or even incomplete release of ibuprofen. 12,69…”

“…To find out the mechanisms governing the IBU release, the data were fitted in Korsmeyer–Peppas model 69 (Fig. 11(B), solid lines).…”

“…The release behavior is explained by the drug matrix mixture compression (diffusion constraints) and the surface area and pore volume of bioactive glass, which induce a slow or even incomplete release of ibuprofen. 12,69 To qualify the mechanism of drug release, various researchers have explained it using various models. 70 For example, Korsmeyer and Peppas proposed an empirical equation to model Fickian and non-Fickian drug release from different materials (eqn (3)).…”