Controlled block glycopolymers able to bind specific proteins

Abstract

The syntheses of a variety of amphiphilic block glycopolymers based on 2‐{[(D‐glucosamin‐2‐N‐yl)carbonyl]oxy}ethyl acrylate and n‐butyl acrylate or methyl methacrylate by single‐electron transfer‐living radical polymerization (SET‐LRP) are described. In a first step, the homopolymerization of unprotected acrylic glycomonomer to obtain well‐controlled glycopolymers is studied. Posterior and based on these studies, di‐ and triblock glycopolymers were synthesized via SET‐LRP of the glycomonomer from different hydrophobic blocks, varying the hydrophilic block lengths. All the copolymers are characterized by nuclear magnetic resonance spectroscopy and GPC. Moreover, their water solution behavior by dynamic light scattering and their capacity of interaction with Concanavalin A lectin by turbidimetry are analyzed. The effect on the block glycopolymers behavior of hydrophobic block nature and the length of glycopolymer segments is evaluated. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013

Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis

“…187 In addition, relatively small changes in ligand concentration can dramatically affect the end-group fidelity of the polymer chains, highlighting the importance of the ligand in Cu(0)-mediated polymerizations. 84 netriamine (PMDETA), 58,71,79,92,96,134,135,138,150 and tris(2-aminoethyl)amine (Tren) 79,136 have also been utilized as disproportionation in the presence of these ligands is near quantitative and polymerization proceeds with equally high end-group fidelity although a bit slower. 189 Interestingly, although Tren provided a slower polymerization rate when compared with Me 6 -Tren, the high end-group functionality was maintained demonstrating that the commercially available Tren is also an efficient ligand.…”

Functional aqueous assemblies of linear‐dendron hybrids

“…Owing to the recent advances in controlled radical polymerization and “click chemistry” techniques, well‐defined glycopolymers can be synthesized in the presence of their hydroxyl functionalities . Glycopolymers with various architectures can be self‐assembled to generate assemblies such as micelles or vesicles . Glycodendrimers have also been extensively explored .…”

Chemical modification of block copolymers based on 2-hydroxyethyl acrylate to obtain amphiphilic glycopolymers

“…[ M w /M n =1.16) and Br-PBA 91 -Br (M n,SEC =11,600 g/mol; M w /M n =1.16), respectively, were synthesized via ATRP as reported in previous works. [54,56] Herein, di-and triblock copolymers were prepared by chain extension reaction of HEA from those PBA macroinitiators using a relation of …”