Controlled delivery of gold nanoparticle-coupled miRNA therapeutics<i>via</i>an injectable self-healing hydrogel

Ven, Casper F.T. van der; Tibbitt, Mark W.; Conde, João; Mil, Alain van; Hjortnaes, Jesper; Doevendans, Pieter A.; Sluijter, Joost P.G.; Aikawa, Elena; Langer, Robert

doi:10.1039/d1nr04973a

Cited by 19 publications

(15 citation statements)

References 50 publications

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“…To prepare tumor-bearing mice, MCF-7 tumor cells (1 × 10 7 cells in normal saline) were subcutaneously injected into female nude mice. When the tumor volume reached 50–100 mm 3 , mice were divided into six groups with different treatments: PBS ( n = 6, 25 μL), PBS + laser ( n = 6, 25 μL), nanoflare ( n = 6, 25 μL 400 nM), nanoflare + laser ( n = 6, 25 μL 400 nM), NC ( n = 6, 25 μL 400 nM) and NC + laser ( n = 6, 25 μL 400 nM) . Then, the drug was injected intravenously into the tumor according to the above group, respectively.…”

Section: Methodsmentioning

confidence: 99%

Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy

Yang

Tong

et al. 2022

Anal. Chem.

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Theranostics, which combines both diagnostic and therapeutic capabilities in one dose, has always been an intractable challenge in personalized cancer treatment. Herein, a versatile nanotheranostic platform "nanoflare couple (NC)" has been developed for in situ multiplex cancer-related mRNA imaging and subsequent logic-controlled aggregation of gold nanoparticles, leading to gene therapy and photothermal therapy upon irradiation with infrared light. As a proof of concept, TK1 and survivin mRNAs that are highly expressed in most tumor tissues are selected as endogenous cancer indicators and therapy triggers to design the NC. Mice bearing breast cancer cells MCF-7 are prepared as a model to test its efficacy. The in vitro and in vivo assays validate that the NC show the capability for multiplexed mRNA imaging and high efficiency for logic-controlled combinational therapy of breast cancer.

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Section: Methodsmentioning

confidence: 99%

Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy

Yang

Tong

et al. 2022

Anal. Chem.

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“…Furthermore, it was discovered that AuNP‐miR‐214 continued to function after delivery in a 3D bioprinted human CAVD model and a 2D in vitro miR‐214 target luciferase reporter test. In addition, AuNP‐miRs were cleared by 11 days in mice following subcutaneous injection of the hydrogel 84 . Schematic structure of hydrogel is shown in Figure 3.…”

Section: Nanomaterials Based Self‐healing Composites Applicationsmentioning

confidence: 99%

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Mollajavadi,

Tarigheh,

Eslami‐Farsani

2023

Polymer Composites

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Materials that can recover the function of lost or damaged parts, called self‐healing materials, have attracted attention due to their wide usage in different fields such as water refinery, coatings, robotics, and especially, biomedical applications. Depending on whether the self‐healing component is added to the polymer or is inherent to the polymeric matrix, the self‐healing properties of the polymeric materials can be classified into extrinsic and intrinsic self‐healing. Hydrogels are one of the most used polymers in self‐healing applications for various purposes, including tissue engineering, drug delivery, etc. Nanoparticles can endow some essential features to hydrogels, such as improving mechanical properties, more efficient healing ability, conductivity, and antibacterial and magnetic features. In the current study, various biomedical applications of self‐healing polymers using nanoparticles are discussed in detail, showing the impact of addition of nanoparticles. Perfect antibacterial properties with the addition of copper sulfide or silver nanoparticles were achieved. In addition, enhancing compression modulus up to three times and endowing conductivity to the hydrogel as the effect of carbon nanotube addition and better mechanical properties caused by graphene oxide and iron oxide nanoparticles were reported. These are just a few examples of the results achieved by adding nanoparticles to the self‐healing polymers described in this study.

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“…Colloidal nanocarriers have been under intense investigation for their use in drug delivery and imaging applications. Carriers, such as liposomes, polymer vesicles, and micellar dispersions, have shown great potential in solubilizing hydrophobic drugs. , Polymer nanodroplets offer enhanced synthetic versatility, drug loading capacity, stability, and biocompatibility. − Combinations with inorganic contrast agents having a metallic core, such as gold nanoparticles (AuNPs), are promising contenders for biomedical imaging. ,, Most of these applications require working in aqueous media, which can be problematic for hydrophobic nanoparticles, since they are susceptible to aggregation in aqueous solutions. ,, Encapsulation of these hydrophobic nanoparticles within a water-soluble vehicle has also been a challenge …”

Section: Introductionmentioning

confidence: 99%

“…2−5 Combinations with inorganic contrast agents having a metallic core, such as gold nanoparticles (AuNPs), are promising contenders for biomedical imaging. 3,6,7 Most of these applications require working in aqueous media, which can be problematic for hydrophobic nanoparticles, since they are susceptible to aggregation in aqueous solutions. 6,8,9 Encapsulation of these hydrophobic nanoparticles within a water-soluble vehicle has also been a challenge.…”

Section: ■ Introductionmentioning

confidence: 99%

Inorganic Nanoparticles Embedded in Polydimethylsiloxane Nanodroplets

Lteif,

Nosratabad,

Wang

et al. 2023

Langmuir

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To stabilize and transport them through complex systems, nanoparticles are often encapsulated in polymeric nanocarriers, which are tailored to specific environments. For example, a hydrophilic polymer capsule maintains the circulation and stability of nanoparticles in aqueous environments. A more highly designed nanocarrier might have a hydrophobic core and a hydrophilic shell to allow the transport of hydrophobic nanoparticles and pharmaceuticals through physiological media. Polydimethylsiloxane, PDMS, is a hydrophobic material in a liquid-like state at room temperature. The preparation of stable, aqueous dispersions of PDMS droplets in water is problematic due to the intense mismatch in surface energies between PDMS and water. The present work describes the encapsulation of hydrophobic metal and metal oxide nanoparticles within PDMS nanodroplets using flash nanoprecipitation. The PDMS is terminated by amino groups, and the nanodroplet is capped with a layer of poly(styrenesulfonate), forming a glassy outer shell. The hydrophobic nanoparticles nucleate PDMS droplet formation, decreasing the droplet size. The resulting nanocomposite nanodroplets are stable in aqueous salt solutions without the use of surfactants. The hierarchical structuring, elucidated with small-angle X-ray scattering, offers a new platform for the isolation and transport of hydrophobic molecules and nanoparticles through aqueous systems.

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Controlled delivery of gold nanoparticle-coupled miRNA therapeuticsviaan injectable self-healing hydrogel

Abstract: A novel injectable hydrogel drug delivery platform introduces miRNA therapeutics coupled to gold nanoparticles to cells in a 3D bioprinted heart valve disease model.

Cited by 19 publications

References 50 publications

Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy

Nanoflare Couple: Multiplexed mRNA Imaging and Logic-Controlled Combinational Therapy

Self‐healing polymers containing nanomaterials for biomedical engineering applications: A review

Inorganic Nanoparticles Embedded in Polydimethylsiloxane Nanodroplets

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